2. SbD: definition?
o safer production: ensuring industrial safety
during the production of NM;
SbD in nanotechnology, 3 key elements:
o safer material/product: minimising, in the
R&D phase, possible hazardous properties of
NM or product while maintaining function;
o safer use and end-of-life: minimising
exposure and associated adverse effects
through the entire use life, recycling and
disposal of the NM product, thus supporting
circular economy.
3. Product
idea Design Prototype Testing
Manufactu
ring
Safety
assessme
nt
Product
idea Design Prototype Testing
Safety
assessme
nt
Manufactu
ring
Product
idea
Design
(function)
Design
(safety) Prototype Testing
Manufactu
ring
….and beyond: decommissioning, disposal, recycling
SbD: in practice
4. EU projects past, present, future
o Large projects: NANoREG, NanoRegII
o Technology focus: ACEnano, npSCOPE
o Method focus: PATROLS, GRACIOUS
o Governance focus: RiskGone, Gov4Nano,
NanoRIGO
o Data focus: NanoCommons
o Model focus: NanoSolveIT, NanoinformatiX
o Forthcoming call: Safe by design, from science
to regulation: metrics and main sectors (RIA)
6. 1. Direct particle
size and multi-
element
composition
analysis
2. Method
development and
hyphenation
4. Method
miniaturisation
and
simplification
3. Extension of the
range of
characterisation
assays 5.
Harmonization
of sample
introduction
Pathways to analytical innovation
7. Analytical and Characterisation
Excellence in nanomaterial risk
assessment: A tiered approach
Current nanosafety
toolbox ACE nano
Future nanosafety
toolbox
ICP-MS
AFM
DLS
NTA
Confocal
UV-vis
BET TEM
XPS
ToF-SIMS SEM
Raman
TS
NT
FFF
Tiered access (1è4)
Automated Sample PreparaGon/IntroducGon
System
Interface 1
Interface 2
Interface 3
Interface 4
Size,
shape
Surface
character-
izaGon
Chemical
composiGon
Exposure
Microscopy
SeparaGon
Spectroscopy
Mass Spec
Spectroscopy
Microscopy
Tensiometry
Surface Area
Mass Spec
Microscopy
Spectroscopy
Air-Liquid
Interface
