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Lab#6: Sequence Alignment (Local)
Asian University For Women
BINF 2000: Introduction to Bioinformatics
(Lab - Fall 2022)
Syed Mohammad Lokman
Instructor
Asian University for Women
2
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
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BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
4
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
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BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
6
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
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BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Diagonal Horizontal Vertical
Match or
Mismatch
Gap
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BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Match or
Mismatch
Gap
Gap
9
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
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BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Lab#5 mini-assessment:
Global Sequence Alignment
S1 = A T C A G A G T C
S2 = T T C A G T C
Match= 2; MisMatch= 0; Gap Penalty= - 2
11
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Lab#5 mini-assessment:
Global Sequence Alignment
12
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Lab#5 mini-assessment:
Global Sequence Alignment
13
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Lab#5 mini-assessment:
Global Sequence Alignment
ATCAGAGTC
| | | | | | : 8
TTCAG - - TC
ATCAGAGTC
| | | | | | : 8
TTC - - AGTC
ATCAGAGTC : 8
| | | | | |
TTCA - - GTC
14
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
15
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
16
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
17
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
18
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
19
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
20
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
21
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
22
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
23
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
24
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
25
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Lab#6 Exercise:
Local Sequence Alignment
26
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Lab#6 Exercise:
Local Sequence Alignment
27
BINF 2000: Introduction to Bioinformatics (Lab) Syed Mohammad Lokman (syed.lokman@auw.edu.bd)
Lab#6 Exercise:
Local Sequence Alignment

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Local Alignment