3. INTRODUCTION :
The definition of coordination exercises is the
ability to execute smooth, accurate, controlled
motor responses (optimal interaction of muscle
function).
Coordination is the ability to select the right
muscle at the right time with proper intensity to
achieveproper action.
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6. GRIP STRENGTH MODEL :
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The test is being used to assess muscular strength or
neuromuscular function in rodents which can be
influenced not only by sedative drugs and muscle
relaxant compounds but also by toxic agents.
Purpose and rational
7. PROCEDURE :
The method was described a s ‘test de-
l’agrippement’ by Boissier and Simon (1960). Male or
female mice with an average weight of 22g are used.
In a preliminary experiment the animals are tested for
their normal reactivity.The animals are exposed to a
horizontal thin threat or metallic wire suspended about
30 cm into the air which they immediately grasp with
the forepaws.
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8. CONT....
The mouse is released to hang on with its forelimbs.
Normal animals are able to catch the threat with the
hind limbs and to climb up within 5sec.Only animals
who fulfill this criterion are included into the
experiment. Ten mice are used in the control group and
in the experimental groups.After oral or subcutaneous
administration the animals are tested every 15min.
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9. CONT....
Animals which are not able to touch the threat with the
hind limbs within 5 s or fall off from the threat are
considered to be impaired.The test is continued for 2hr
.The animals are observed for their behavior in the
cages. Only if their behavior and their motility in the
cage seem to be normal the disturbance of the
grasping reflex can be considered a s caused by
central relaxation
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10. CONT....
EVALUATION :
The percentage of animals loosing the
catching reflex is calculated. By use of
different doses,ED50-values are calculated.
Likewise, time- response curves can be
established.
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11. REFERENCE :
Gerhard Vogel;Drug discovery and Evaluation–
Pharmacological Assays; Second Edition pp 397-398.
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