The document discusses erectile dysfunction (ED), its causes, and treatments. It defines ED as the inability to maintain an erection for satisfactory sexual performance. Causes of ED include neurogenic factors like diabetes or spinal cord injury, psychogenic factors like anxiety or depression, neurological issues like stroke or damage to the spinal cord or nerves, and endocrine disorders like diabetes or hypogonadism. Common drugs used to treat ED work by inhibiting phosphodiesterase type 5 (PDE5) to increase levels of cGMP, a messenger involved in erectile function. Examples given are sildenafil, tadalafil, and vardenafil. Sildenafil is discussed in more detail, including its chemical structure,

1. Mr. ANSARI SHOAIB AHMED
DRUGS ACTING ON ERECTILE
DYSFUNCTION

2. Mr. ANSARI SHOAIB AHMED
ERECTILE DYSFUNCTION
• (ED) is a condition that can be a result of neurogenic, hormonal vascular disorders.
• Male sexual dysfunction is inability to attain a satisfactory sexual relationship, may
involve lack of erection or problems with release, ejaculation, or orgasm.
• Erectile dysfunction is the inability to maintain an erection required for a satisfactory
sexual performance.
• Premature ejaculation refers to uncontrolled ejaculation before or shortly after
entering the vagina.

3. Mr. ANSARI SHOAIB AHMED
• Retarded ejaculation usually is synonymous with delayed ejaculation.
• Retrograde ejaculation denotes backflow.
• Nitric Oxide (NO) plays significant role in erectile function of penis in male.
• During the sexual stimulus nitric oxide (NO) is released from nerve endings and
endothelial cells in the corpus cavernosum (erectile tissue of the penis).
• This released NO enhance blood flow into corpus cavernosum of penis and cause
erection.

4. Mr. ANSARI SHOAIB AHMED
A. NEUROGENIC
• Diabetes
• Spinal cord injury
• Polyneuropathy
• Myelopathy
• Multiple sclerosis .
• Alcohol abuse or parkinsonism
• Radical pelvic surgery
CAUSES OF ERECTILE DYSFUNCTION

5. Mr. ANSARI SHOAIB AHMED
B. PSYCHOGENIC
• Performance anxiety
• Depression
C. NEUROLOGIC
• Cerebrovascular accident
• Spinal cord damage
• Autonomic neuropathy
• Peripheral neuropathy
D. ENDOCRINE
• Diabetes mellitus
• Hypogonadism
• Hyperthyroidism
• Hypothyroidism

6. Mr. ANSARI SHOAIB AHMED
CLASSIFICATION
PHOSPHODIESTERASE -5 INHIBITORS
1. Sildenafil
2. Acetildenafil
3. Tadalafil
4. Vardenafil

7. Mr. ANSARI SHOAIB AHMED
1. SILDENAFIL
•5-{2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-pro
pyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

8. Mr. ANSARI SHOAIB AHMED
PROOPERTIES
Sildenafil is White Crystalline Solid.
Sildenafil is is Water Soluble
Sildenafil has 189-190 °C melting point
МОA
sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown
via phosphodiesterase type 5 (PDE5).
CLINICAL USES
1 Used in the management of erectile dysfunction
2. Used as vasodilator
3. Sildenafil reduce symptoms in patients with pulmonary arterial hypertension
(PAH). DOSE The typical dose of Sildenafil is 50 mg orally, taken 1 hour before sexual
activity.

9. Mr. ANSARI SHOAIB AHMED
1. Tadalafil