formulation- lokanath rasa

1. FORMULATION SEMINAR
Lokanath rasa
Dr. Shivani Pandey
1st year P.G . Scholar
Dept of Rasashastra and Bhaishajya
kalpana

2. Contents
• Introduction
• Objective
• Reference
• Formulation - Ingredients
• Indications
• Pharmaceutical Part
• Cross references
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3. Cont’d…
• Pharmacodynamics of drugs
• Critical analysis of ingredients
• Manufacturing Companies
• Research Works
• Discussion
• Own research view
• Summary
• Conclusion
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4. Introduction
• ‘LOKANATH’ means lord of the universe.
• Kharaliya Rasayana (among chaturvidha rasayana).
• 10 different methods of preparation.
• It is mainly used for liver and spleen disorders.
• Yakrit comes from Sanskrit word i.e., yat
(conversion) It is also narrated as yakrit sabita (liver
is sun).
• In vedic literature from the liver can be manifested as
allergies, high cholesterol, hypoglycemia,
constipation, digestive problems, or fatigue.
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5. • If the imbalance continues for a long time,
serious diseases of the liver, including
hepatitis, cirrhosis, jaundice and cancer, could
develop Nonalcoholic Fatty Liver Disease
(NAFLD), viral hepatitis B and hepato cellular
carcinoma survival.
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6. Objective
• To study the method of preparation and
rationality behind the indications of Lokanath
Rasa.
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7. Pharmaceutical Part
 Poorva Karma
 Pradhana Karma
 Pashchat Karma
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8. Poorva Karma
1. Identification and authentication of raw drugs required.
2. Equipments and instruments required.
• Small scale – Khalwa yantra, weighing machine , siever,
steel vessel.
• Large scale- Pulverizer
Electrically operated mixing machine
Wide mouth stainless steel vessel
Wet Grinder
Granulator
Tablet making machine
Tablet coating pan
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9. Formulation
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10. Reference
• BBR 6378 i.e., R.S.S. pliha roga chikitsa ch.
2/6-14
• B.R.
• Ras raj sundar
• R. Ch. M. adhyay 9
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11. Ingredients
Ingredient Latin name Chemical formula Quantity
Shuddha Parada Hydrargyrum Mercury 1 part
Shuddha Gandhaka Sulphurium Sulphur 2 + 2 part
Abhraka bhasma Mica Calyx of mica 1 part
Tamra bhasma Cuprum Calyx of copper 2 part
Lauha bhasma Ferrum Calyx of iron 2 part
Varati bhasma Cyprea moneta
linn
Calyx of Varati 2 part
Ingredient Botanical
name
Family Quantity
Ghritakum
ari swarasa
Aloe vera Lilliaceae q.s.
Kakamachi
swarasa
Solanum
nigrum
Solanaceae q.s.
Jambiri
nimbu
swarasa
Citrus
limon
Rutaceae q.s.
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12. Drugs
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13. Bhavana dravya
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14. 3. Parada shodhana.
4. Gandhaka shodhana.
5. preparation of Kajjali (1:2)
6. Abhraka bhasma preparation.
7. Tamra bhasma preparation.
8. Lauha bhasma preparation.
9. Kapardika bhasma.
10.Juice extract of Ghritakumari swarasa,
Kakamachi swarasa, Jambiri nimbu swarasa.
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15. Pradhana Karma
• Take prepared Kajjali in a khalwa yantra.
• Add abhraka bhasma equal to parada and
triturate it with ghritakumari swarasa.
• Add tamra bhasma (2 part) & lauha bhasma (2
part) along with kakamachi swarasa.
• Add shuddha gandhaka (2 part) along with
kapardika bhasma (2 part) & jambiri nimbu
swarasa in khalwa.
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16. Cont’d…
• Give gajaputa & allow it to get swang sheeta.
• Triturate it again.
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17. Observations
• During kajjali preparation, trituration is done until
smooth black coloured powder is formed until it
passes Rekhapurnatva and nischandrikarana.
• During vati preparation, bhavana is done until it
becomes smooth, soft in texture, turned to
desired shape when pressed between fingers and
when rolled between fingers cracking should not
occur.
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18. Precautions
• Identify the genuine raw drugs.
• Maintain proper hygiene.
• Ingredients should be free from foreign particles.
• All the ingredients should be dry and pounded
separately.
• Maintain homogeneity of particle size (mesh size)
of individual churnas.
• Minimize wastage by spilling etc.
• Shade drying.
• Uniformity of weight.
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19. Pashchat Karma
• Preserve the vati in air tight container.
• Label it with appropriate details and stored.
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21. SN Drug Rasa Guna Virya Vipaka Doshaghnata Karma
1. Shuddha
Parada
Shadarasa _ Sheeta Madhura Tridosha
shamana
Rasayana
2. Shuddha
Gandhak
a
Madhura,
Katu,
Kashaya
Sara Ushna Madhura Kapha-
Vatagna
Dipana , Aama
pachana, , Antidote
of Parada, Dooshi
visha hara
3. Abhraka
bhasma
- Madhur
a
snigdha,
sheeta
Sheeta Vata –
pittaghna ,
kaphaghna
Rasayana, rushya,
balya, arsha,
pandu, kushtha,
amlapitta,
swetapradar,
prameha
4. Tamra
bhasma
Tikta,
katu,
kshaya,
Madhura
Laghu Ushna Madhura Pitta –
kaphaghna
Lekhana, ropana,
deepana, netraya
5. Lauha
bhasma
Tikta,
kshaya,
Madhura
Sara ,
guru,
ruksha
Sheeta Madhura Tridosha Rasayana,
ojo,tejo,kanti
vardhaka
6. Varati
bhasma
Katu Ushna Vata-
kaphaghna
Deepani , grahani
nashini, paridam
shoola
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22. Bhavana
Dravya Rasa Guna Virya Vipaka Doshaghnata Karma
Ghrita
kumari
swarasa
Katu Guru,
snigdha,
pichhila,
Sheeta Tikta Kapha-
pittahara
Shothahara,
vednasthapana,
vranaropana
Kakamachi
swarasa
Tikta Laghu,
snigdha
Anushna Katu Tridoshaghna Shothahara,
vranashodhana,
Vedanasthapana,
Savarnikarana
Jambiri
nimbu
swarasa
Amla Guru,
tikshna
Ushna Amla Kapha-
vatahara,
pittahara
Rochana,
deepana,
pachana,
Anuloana,
pittasaraka,
krimighna
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23. Dravya Prayojyanga Sansthanika karma Sansthanika prayoga
Ghrita
kumari
swarasa
Patra Yakritauttejaka, highly
virechaka property, krimighna,
Acts on small & large
intestine, increases its
movement, rakta shodhaka,
shothahara
Pliha- yakrita vriddhi, krimi
roga(tantukrimi),
Rakta vikara, shotha,
Kakamachi
swarasa
Phala
swarasa
Shothahara, yakritauttejaka,
pittasaraka, rechaka,
raktabhara nashaka,
Yakrita shotha, yakrita
vikara, yakrita vriddhi,
plihavriddhi
Jambiri
nimbu
swarasa
Phala
swarasa
Pittasaraka, krimighna, hridya Yakrita vikara , krimi roga
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24. Dose & anupana
Matra – 6 ratti (now, 125-250mg)
Anupana –
i. Pippali churna + madhu
ii. Haritaki churna + guda
iii. Zeeraka churna + guda+ gomutra
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25. Anupana
Dravya Rasa Guna Virya Vipaka Doshaghnata
Pippali
churna
Katu Laghu,
snigdha,
tikshna
Anushnasheeta Madhura Kapha-
vataghna
Haritaki
churna
Pancharasa(lava
na varjita)
kashaya
pradhana
Laghu,
ruksha
Ushna Madhura tridoshahara
Zeeraka
churna
Katu Laghu,
ruksha
Ushna Katu Kapha
vataghna,
pittavardhaka
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26. Dravya Sansthanika karma Sansthanika prayoga
Pippali churna Raktotkleshaka, jantughna
yakrittotejaka,
plihavriddhihara, krimighna
Yakrita vikara, plihavriddhi,
krimighna, rakta vikara, pandu,
Haritaki churna Shothahara, yakritauttejaka,
mridurechana, anuloana,
krimighna, shoditasthapana,
yakrita, pliha, krimi, srotoshodhaka,
Raktavikara,
Zeeraka churna Shothahara Krimi, raktavikara
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Cont’d…

27. Analytical Part
 Raw drug analysis – organoleptic characters , foreign matter,
ash value etc.
 Analysis during procedure – churna characters – Ash value,
Extractive value, Particle size, Moisture content, Microbial
load, TLC/ HPTLC.
 End product analysis – organoleptic characters,
physicochemical parameters, Microbial contamination ,
Dissolution , Disintegration time, Hardness, Friability,
Uniformity of weight etc.
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28. Indications
• Yakrita roga
• Pliha roga
• Shawathu
• Vata ashthila
• Kamathi
• Praytasthila
• Kansyakroda
• Agramansa
• Shoola
• Bhagandar
• Agnimandya
• Kasa
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29. Critical analysis
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34. Cross references
• Yogaratnakar chikitsa m. adhyay 7
• Sharangdhar samhita madhyam khanda ch 12, RPS Ch 8,
Yogaratnakara chikitsa m
• For brihat - B.R. ,Ras raj sundar , Rasendra sar sangraha
pliha rog chikitsa ch 2, R. Ch. M. adhyay 9
• R. Ch. M. adhyay 9
• B.R. , RSS atisara, RRS ch 16
• Laghu – Sh. Samhita khanda 2 adhyay 12, RR kshaya
• B.R. , RSS, R Ra Su, R. Ch. Pliha , Dhan. Udar, R.
chintamani adhyay 9
• R. Chintamani ch. 9
• RRS U adhay 14, yogaratnakar kshaya , R Ra Su, RSS
Rajyakshma
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35. Yogaratnakar chikitsa m. adhyay 7
Kaparda bhasma 2 part
Shankha bhasma 2 part
Shuddha parada 1 part
Shuddha gandhaka 1 part
Maricha churna 1 part
Bhawna by nimbu swarasa q.s.
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Anupana – takra in grahani
Matra – Masha

36. Sharangdhar samhita madhyam khanda ch 12,
RPS Ch 8, Yogaratnakara chikitsa m
Shuddha bhubhukshita parada 2 part
Shuddha gandhaka 2 part
Kaparda 8 part (fill kajjali)
Tankana 1 part paste to close it
Godugdha q.s.
Shankha pieces 8 part
Chuna paste To paste sharava
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• Gajaputa
• 6 R + 28 marich – V roga
• 6 R + Navneet – P roga
• 6 R + madhu – K roga
• Atisara, kshaya, aaruchi,
sangrahani, krishta,
• agnimandya, kasa, shwasa, gulma
• 3 ghras ghrita yukta bhat and
without pillow
• Amla rahita ghrita yukta anna, itha
dhadhi
• Evening- dudha bhat, ghrita moong
bada
• Tila, amla/ ghita abhyanga –
mandoshna snan

37. R. Ch. M. adhyay 9
Shuddha parada 1 part
Shuddha gandhaka 1 part
Hastishundi swarasa, hingupatri
swarasa
5-5 days mardana
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• Atishi shishi
• Baluka yantra – 1 day manadagni paka
• Yellow color compund
• matra - 1 Ratti
• Agnivridhi , udar roga, jwara
• Kamottejaka, hridya , kanti, madhura swara,
• Khanda, sugarcane, milk, nutritional food.

38. B.R. , R Sa S - atisara, RRS ch 16
Shuddha parada 1 part
Shuddha gandhaka 4 part
Kaparda
Tankana q.s.
Dugdha
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• matra – 2 ratti
• Anupana – madhu,
shunthi, atisa, nagarmotha, devadaru, vacha kwatha
• All types of atisara

39. Laghu – Sh. Samhita khanda 2 adhyay 12,
RR kshaya
Kaparda bhasma 1 part
mandur bhasma 1 part mardana
Ghee (to be cooked) Equal to paste
maricha Equal to shushka ghrita
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• Nagavalli swarasa
• Matra – 1 masha with madhu or navneet for 40 days
• RAJYAKSHMA
• 1- 1 matra after 1 prahar

40. B.R. , RSS, R. Ra. Su., R. Ch. Pliha ,
Dhan. Udar, R. chintamani adhyay 9
Shuddha parada 1 part
Shuddha gandhaka 1 part
Abhraka bhasma 1 part
Loha bhasma 2 part
Tamra bhasma 2 part
Kaparda bhasma 3 part
Nagvalli swarasa q.s.
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• Laghuputa
• Atra- 2-3 ratti
• Anupana – pippali churna+ adhu
jaggery + haritaki
jeera churna
• Yakrita, gulma, udara, pliha, shotha, jirnajwara, pandu, kamala, agnimanya

41. R. Chintamani m. ch. 9
Kaparda bhasma 7 part
maricha 1 part
Shuddha vatsanabha 1 part
Parada bhasma 20 part
shuddha gandhaka 10 part
Ahiphena 4 part
Swarna bhasma ¾ part
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• Sangrahani, kapha roga, vata- pitta prakopa, prameha, mutrakriccha, kasa,
shwasa, bhrama
• Anupana – mishri, ghrita, mocharasa, maricha
• Matra- 2 ratti
• Apathya – krodha, taila, rai, pitta vardhaka dravya, maithun, ratrijagrana

42. RRS U. adhay 14, Yogaratnakar kshaya
R Ra Su, RSS Rajyakshma
Parada bhasma 4 part
Swarna bhasma 1 part mardana
Shuddha gandhaka 8 part
Kaparda q.s.
Dugdha q.s.
Tankana q.s.
Chuna paste q.s.
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• Laghuputa
• Viryavardhaka
• Matra – 4 ratti
• Marich churna + madhu
• Krishta, agnimandya, kasa, hikka in
3 days
• Apathya – lavana varjita
• Pathya - ghita + dadhi bhojan
21 days marich churna + ghrita pan

43. Manufacturing Companies
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44. • Presentation – 40 tab
• Price range- 100
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45. Research Works
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46. Discussion
• Shu Parada and Shu Gandhaka enters srotas due
to its Yogavahi guna, does sroto shudhi.
• The abhraka, lauha bhasmas reaches to minute
raktavaha srotas thus, increases the haeme content
in blood due to the iron satva in it.
• Most of the copper in huan body is in muscle and
liver thus, tamra bhasma helps in improving it’s
quantity.
• Kapardika bhasma is having a good deepana
property and being a good source of calcium
improves it’s level in blood.
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47. Own research view
• Analytical & comparative study on Lokanath
rasa using different methods by different
acharya’s.
• Clinical study of Lokanath Rasa with different
Anupana in different condition.
• Clinical study on different varities of
formulation explained by different
Accharya’s.
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48. Summary
• Introduction and References of formulation
• Ingredients
• Pharmaceutical Part
• Cross references
• Pharmacodynamics of drugs
• Critical analysis of ingredients
• Applied aspect
• Manufacturing Companies
• Research Works
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49. Conclusion
• Lokanath Rasa is a herbomineral preparation.
• Most of the drugs have tridoshaghna property,
yakrita vriddhihara, pliha vriddhihara property
and krimighna property.
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