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History
Paul Gyorgy
Rudolf Peter
Structure
 The alcohol form =PYRIDOXINE.
 The aldehyde form= PYRIDOXAL
 The amine form= PYRIDOXAMINE
Vitamin B6 phosphorylated forms
Sources
Metabolic Role
 Transamination:
 Deamination:
 Decarboxylation
 Condensation
 Transport of K+
 Synthesis of arachidonic acid:
Linoleic acid PLP Arachidonic acid
PLP
Absorption and excretion
 Readily absorbed in jejnum
and ileum of small intestine
 Widely distributed in various
tissues
 Stored in muscles, plasma,
liver and RBCs.
 Stored for 25-33days
 Excreted mainly by kidney
and small quantity by sweat
and faeces.
Deficiency
 Weakness
 Sleeplessness
 Hallucination
 Anemia
 Down Syndrome
 Epilepsy
Treatment
 Improve mood and reduce symptoms of
depression
 Promote brain health.
 Prevent and treat anemia by aiding hemoglobin
production.
 Prevent clogged artries and reduce heart disease
risk.
Toxicity
RDA=100mg/da
y.
More than
200mg/day cause
peripheral
neuropathy
which leads to
numbness in
hands and feet.

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