Cardiomiopathies Based on Leslie Cooper UptoDate paper

1. AHA 2006 and ESC 2008
• HTN
• CAD
• Valvular Heart Disease
• Congenital Heard Disease
• Inflammation

2. DCM/Congestive Cardiomiopathy
-Global hypokinesia
-Systolic failure
-Spherical shape cavity/dilation
-Normal/increase in total cardiac mass
-5-8/100k
-Viruses and gene mutations

3. HCM/Asymmetric HCM
-Beta myosin heavy chain and Binding Protein C
-Hyperkinetic
-Diastolic/Systolic dysfunction
-50% F (AD)/S
-100% Genetic
-Young athletes (sudden death)12-16mm

4. RCM
-Infiltration ( abnormal protein, sarcoidosis granuloma,
hemochromatosis)
-Failure to relaxation (Diastole dysfunction)
-NonHypertrophic/Dilated
-Endomyocardial fibrosis (Eo; Apical and subvalvular)

5. Arrhythmogenic right ventricular CM
• RV free Wallfibrous/fatty tussue w/ scattered residual myocardial
cells.
• Regional akinesis
• Desmosomal genes (40-60%)

6. Unclassified cardiomyopathies
• Left Ventricular noncompaction
- Cavity and Deep intratrabecular recesses
- HF, TE, Arrhythmias
• Stress-induced cardiomyopathy (takotsubo)
-transient systolic dysfunction of apical or mid segments of LV by stress