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Therapeutic Hypothermia Reduces Lactate for Post-Resuscitation Syndrome
1. THERAPEUTIC HYPOTHERMIA
FOR POSTRESUSCITATION
SYNDROME AND LACTATE
LEVELS
Sule AKIN, Assoc.Prof, MD
Baskent University School of Medicine
Anesthesiology and Critical Care Department
Adana - TURKEY
2nd World Congress on BIOMARKERS & CLINICAL RESEARCH
Baltimore, Maryland , USA. – 13 September 2011
13. • Ischemia and reperfusion syndrome
• Inflammatory response
• Coagulopathy
• Circulatory failure
• Adrenal dysfunction
Current Opinion in Crit Care. 2004
u
t
18. WHAT WILL WE DO
AFTER THE CRISIS
(CPR) ENDS?
POST CPR
INTENSIVE CARE
19. Common intensive care
protocols
Sedation and neuromuscular
blockade
Monitorisation Seizıre control and propylaxis
Early hemodynamic
optimisation
GLUCOSE control
Oxygenation Neuroprotection by drugs
Ventilation Adrenal dysfunction treatment
Circulatory support Renal failure management
Acute Coronary Syndrome
management
Infection control
PRS- TREATMENT STRATEGIES
20. Common intensive care
protocols
Sedation and neuromuscular
blockade
Monitorisation Seizıre control and prophylaxis
Early hemodynamic
optimisation
GLUCOSE control
Oxygenation Neuroprotection by drugs
Ventilation Adrenal dysfunction treatment
Circulatory support Renal failure management
Acute Coronary Syndrome
management
Infection control
PRS- TREATMENT STRATEGIES
21. THERAPEUTIC HYPOTHERMIA
Common intensive care
protocols
Sedation and neuromuscular
blockade
Monitorisation Seizıre control and propylaxis
Early hemodynamic
optimisation
GLUCOSE control
Oxygenation Neuroprotection by drugs
Ventilation Adrenal dysfunction treatment
Circulatory support Renal failure management
Acute Coronary Syndrome
management
Infection control
PRS- TREATMENT STRATEGIES
34. European Resuscitation Council Guidelines for Resuscitation
2010 Section 1. Executive summary
Jerry P. Nolana, Jasmeet Soarb, David A. Zidemanc, Dominique
Biarentd, Leo L. Bossaerte, Charles Deakinf, Rudolph W. Kosterg,
Jonathan Wyllieh, Bernd Böttigeri, on behalf of the ERC Guidelines
Writing Group1
Therapeutic Hypothermia
There is good evidence supporting the use of induced hypothermia in comatose survivors of out-of-
hospital cardiac arrest caused by VF. One randomised trial and a pseudorandomised trial669
demonstrated improved neurological outcome at hospital discharge or at 6 months in comatose patients
after out-of-hospital VF cardiac arrest. Cooling was initiated within minutes to hours after ROSC and a
temperature range of 32–34 ◦C was maintained for 12–24 h. Two studies with historical control groups
showed improvement in neurological outcome after therapeutic hypothermia for comatose survivors of
VF cardiac arrest. Extrapolation of these data to other cardiac arrests (e.g., other initial rhythms, in-
hospital arrests, paediatric patients) seems reasonable but is supported by only lower level data.
Out-of-hospital CPR, In –hospital CPR
VF, PVT, Asistoly, PEA
First 6 hours, 32-34 C
For 12-24 hours
42. MY CLINIC’S EXPERIENCE
• Lactate ;
• Retrospective investigation
• 63 resuscitated patient
• Group I (n=33) ; TH administered patients
for 24 hours (32-35 C)
• Grouıp II (n=30) ; No TH
A predictor of neurologic outcome?
43.
44. MY CLINIC’S EXPERIENCE
• Initial cardiac arres t rhythms
• ICU admission times
• Initial and after 24 hours Glasgow Coma
Scales (GCS) and Cerebral Performance
Categories (CPC)
• Lactate
• AST, ALT
• BUN, Creatinine
Levels at
1st, 3rd, 6th, 12th,
18th, 24th hours
45. Cerebral Performance Categories
(CPC) Scale
CPC 1 Good cerebral performance: conscious, alert, able to
work, might have mild neurologic or psychologic deficit.
CPC 2 Moderate cerebral disability: conscious, sufficient
cerebral function for independent activities of daily life. Able to
work in sheltered environment.
CPC 3 Severe cerebral disability: conscious, dependent on
others for daily support because of impaired brain function.
Ranges from ambulatory state to severe dementia or paralysis.
CPC 4 Coma or vegetative state: any degree of coma without
the presence of all brain death criteria. Unawareness, even if
appears awake (vegetative state) without interaction with
environment; may have spontaneous eye opening and
sleep/awake cycles. Cerebral unresponsiveness.
CPC 5 Brain death: apnea, areflexia, EEG silence, etc.
Safar P. Brain Failure and Resuscitation
Churchill Livingstone, New York, 1981; 155-184
50. MY CLINIC’S EXPERIENCE
• Significant decrease s in lactate levels on
targeted temperature times (6th hours) were
associated with good outcomes of
neurological status
(CPC 1 and CPC 2)
51. SUMMARY
POST RESUSCITATION SYNDROME is a problem caused
by ishemia-reperfusion injury after CPR
Besides “Intensive Care” protocols, THERAEPEUTIC
HYPOTHERMIA is one of the best strategy for PRS
TH does not only improve neurologic outcome but also
helps to cure other organ functions
LACTATE is recommended to follow up as a biomarker
of good neurologic outcome during TH for PRS
52. AT THE END OF THE WORDS…
THE TEAM OF CPR AND PRS
GETS UP ON STAGE…