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Glen Wright Colopy
Personalized Computation
in Medicine
Contact Information
www.currenthealth.com
Twitter: @heycurrent
LinkedIn: https://www.linkedin.com/company/currenthealth
Email: hello@currenthealth.com
Facebook: www.facebook.com/heycurrenthealth
Where might we
want precision in
medicine?
Where can computation achieve that
precision?
Continuous vital-sign monitoring
We want
personalization
because imprecise
clinical practice just
doesn’t work.
University of Pittsburgh
Medical Center Study
• 332 patients
• 112 clinical emergencies
• 7 emergencies detected
• Most detections were late
How can this be
done?
Personalized Expectation
Use 1 noise data point or
a distribution over time?
Step-change detection
Automated model adaptation
Interpreting personalized
dynamics
Personalized Warning Metrics
Heart Rate (bpm) Personal Metric
Personalized Warning Metrics
Heart Rate (bpm) Personal Metric
Decision
Threshold
Simple Interpretable Metrics?
This matters: This doesn’t:
Automated
Adaptation
(a) Deterioration Event
(b) Poor Model Fit
(c) Good Model Fit
Learning from Day 1
Test Different
Heath Settings
Learn Patient’s
Physiology
Improve
Monitoring
Concluding
Places for Personalization
Information & Context Complex Inference
Thank you!
Contact Information
www.currenthealth.com
Twitter: @heycurrent
LinkedIn:
https://www.linkedin.com/company/currenthealth
Email: hello@currenthealth.com
Facebook: www.facebook.com/heycurrenthealth
Why Do Some Artefacts Look Like Artefacts?
Why Do Some Artefacts
Look Like Artefacts?
IID marginal distributions are informative
If you get the marginals right….
If you get the artefact inference right….
Contact Information
www.currenthealth.com
Twitter: @heycurrent
LinkedIn:
https://www.linkedin.com/company/currenthealth
Email: hello@currenthealth.com
Facebook: www.facebook.com/heycurrenthealth

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PMED: APPM Workshop: Personalized Computation in Medicine - Glen Wright-Colopy, March 15, 2019