Acute graft versus host disease by dr. qutaiba abdulah

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Dr. Qutaiba Abdulah

Health & Medicine Technology

years old 2.5
BSAB 21%
Involving back, upper
buttock rt-arm both loin
, area
Scald injury hot milk

& All vital signs
investigations done with ideal
results

She is doing very well with this large
healthy burnd wound

Slow
healing
but
looks
healthy
Pt doing
good

SYSTEMIC SKIN ERRUPTION
ARE SET TO START

EPIDERMALEXFOLATION
OF EAR SKIN & CHEEKS

SCALP LESION
CRUSTATION+

Human GVHD occur after allogenic 
,stem cell transplantation
Acute GVHD describes a distinctive 
syndrome of Dermatitis,Hepatits,&
Enteritis developing within 100 days
of allogenic hematopoietic cell
transplantation
Chronic GVHD describes a more 
diverse syndrome developing after
day 100

EXCISION – RE
AUTO GRAFTING
Who agree with



Who agree with SYSTIMIC STEROID
TREATMENT IF STARTED Auto -SKIN
GRAFTING ARE CONTRAINDICATED



Take biopsy from lesion & from unburned skin a
.maccule 2 cm distant area from the wound
The allograft are excised ,dressing by sofratule 
mesh gauze and povidon iodin impregnated gauze
. bandaging



Clear face no skin lesion
dramatic response

Before
operation

days later 4
After
operation



Separation of epidermis from dermis (bullae like) (x4)
biopsy 2 cm distant from wound {at un burned skin}

Separation of dermis from dermis with upper dermal
inflammation (x10)
)



Upper dermal lymphocytic infiltration (x40) path gnomonic
sign of AGVHD in the Skin

2013 5 11

2013 6 18

Thank you
Dr.qutaiba abdulah aldori
Azadi Hospital kerkuk Iraq

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Acute graft versus host disease by dr. qutaiba abdulah

1. years old 2.5 BSAB 21% Involving back, upper buttock rt-arm both loin , area Scald injury hot milk

5. & All vital signs investigations done with ideal results

6. She is doing very well with this large healthy burnd wound

10. Slow healing but looks healthy Pt doing good

11.

12. SYSTEMIC SKIN ERRUPTION ARE SET TO START

13. EPIDERMALEXFOLATION OF EAR SKIN & CHEEKS SCALP LESION CRUSTATION+

14. Human GVHD occur after allogenic  ,stem cell transplantation Acute GVHD describes a distinctive  syndrome of Dermatitis,Hepatits,& Enteritis developing within 100 days of allogenic hematopoietic cell transplantation Chronic GVHD describes a more  diverse syndrome developing after day 100

15. EXCISION – RE AUTO GRAFTING Who agree with  Who agree with SYSTIMIC STEROID TREATMENT IF STARTED Auto -SKIN GRAFTING ARE CONTRAINDICATED 

16. Take biopsy from lesion & from unburned skin a .maccule 2 cm distant area from the wound The allograft are excised ,dressing by sofratule  mesh gauze and povidon iodin impregnated gauze . bandaging 

17.

18. DESQUAMATION & BULLAE

19.

20.

21.

22.

23.

24.

25. Clear face no skin lesion dramatic response

26.

27.

28. Before operation days later 4 After operation

29.  Separation of epidermis from dermis (bullae like) (x4) biopsy 2 cm distant from wound {at un burned skin}

30.  Irregularity in rete ridges (x4)

31. Separation of dermis from dermis with upper dermal inflammation (x10) )

32.  Upper dermal lymphocytic infiltration (x40) path gnomonic sign of AGVHD in the Skin

33.

34. Auto split thickness Skin-Graft done

35. 2013 5 11 2013 6 18 Thank you Dr.qutaiba abdulah aldori Azadi Hospital kerkuk Iraq

Acute graft versus host disease by dr. qutaiba abdulah

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