8. II.Proliferative phase
A. 2daysto3 weeks
B. Granulation tissueformation(composedof
fibroblasts,macrophagesandendothelial cell)
C. Angiogenesis
D. Contraction
I. Woundedgespulltogethertoreducethe
defect
E. Epithelialization
I. Epithelialcellsmigrateacrossthenewtissueto
formabarrierbetweenthewoundandthe
environment
13. III.Remodeling phase
A. 3weeksto2years
B
. Newcollagen forms whichincreases the
tensilestrengthof thewound
C. 19 types identified. Type 1(80-90%) most
common, found in all tissue. The primary
collageninahealedwound.
D. Type 3(10-20%) seen in early phases of
wound healing. Type V smooth muscle,
Types2,11cartilage,Type4in BM.
17. Wound Strength
Skinwounds
Attheend of firstweek,woundstrength is
approximately10%of unwoundedskin
Wound strength increases rapidly over next 4
weeks and then slows down at approximately
at third month,reaches a plataue at about 70-
80%of thetensilestrengthof unwoundedskin
Scar tissue is never as strong as the original
tissue !!
41. Deficientscar formation
Can leadtotwotypesof complications:
A. WoundDehiscence(ruptureof wound)
mostcommonafterabdominalsurgery
coughing, vomiting,
B. Ulceration- defectinthecontinuity