This document summarizes the UKWIR Chemical Investigations Programme from 2010-2020. The £165M program examined 74 substances at 600 sewage treatment works to establish the likelihood of exceeding environmental quality standards and potential treatment options. Findings showed that most chemicals of concern come from domestic sources and some substances are ubiquitous. Catchment studies showed sewage effluent is not always the main contributor to poor river quality. Economic analyses estimated costs of £27-31BN for end-of-pipe pharmaceutical solutions and found public willingness to pay £73-168/household/year for metal and chemical pollution reductions, though valuations have remaining issues to address.