Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

HCF 2018 Depate: David Warheit

126 views

Published on

DEBATE: Can product stewardship replace regulation? Case nanomaterials
Presentation: David Warheit, Technical Fellow − Toxicology and Risk Assessment, The Chemours Company, US

  • Be the first to comment

  • Be the first to like this

HCF 2018 Depate: David Warheit

  1. 1. Helsinki Chemicals Forum Debate: Can product stewardship replace regulations? Case nanomaterials David B. Warheit, Ph.D. Chemours Company Wilmington, Delaware, USA Helsinki Chemicals Forum June 15, 2018
  2. 2. Product Stewardship – Responsible Care® • Product stewardship provides the platform for companies to identify risks at an early stage and manage those risks along the value chain, thereby enabling adequate protection of human health and the environment. • Product stewardship is an important pillar of Responsible Care®
  3. 3. Product Stewardship – Responsible Care® • Responsible Care®–covers all products including nanomaterials • Responsible Care is self administered – and many companies do third- party audits to evaluate compliance • Many nanoscale materials have been in commerce for decades and have a huge database behind them (fumed silica, carbon black, etc.)
  4. 4. Evaluate Risks Profile Lifecycle(s) Exposure Hazards Properties Assess Risk Mgmt Decide, Document & Act Describe Material & Application Review & Adapt Iterate Assess, prioritize & generate data PS –DuPont/EDF Nano Risk Framework (2007) ISO/TC 229 TR 13121:2011
  5. 5. Hazard Base Set – Guidelines and Methods • Pulmonary Bioassay + full histopathology + NM Characterization – BALF + BrdU + histopath • Skin Irritation Test – OECD 404 • Skin Sensitization – LLNA- OECD 429 • Acute Oral Toxicity Test – OECD 425 • Eye Irritation Test – OECD 405 • Genotoxicity Tests (2) - Ames – OECD 471 Chromosomal Ab Study – OECD 473 • Aquatic Battery (3) - Rainbow Trout – OECD 203; Daphnid –OECD 202; Green Algae – OECD 201
  6. 6. Physicochemical Characterization of Ultrafine TiO2 Particles Sample Crystalline phase Median size and width distribution (nm) Surface area (m2/g) pH Chemical reactivity in water* in PBS deionized water in PBS delta b* F-1 rutile 382.0 ± 36% 2667.2 ± 35% 5.8 7.49 6.75 0.4 uf-1 rutile 136.0 ± 35% 2144.3 ± 45% 18.2 5.64 6.78 10.1 uf-2 rutile 149.4 ± 50% 2890.7 ± 31% 35.7 7.14 6.78 1.2 uf-3 80/20 anatase/ rutile 129.4 ± 44% 2691.7 ± 31% 53.0 3.28 6.70 23.8
  7. 7. OECD Working Party on Manufactured Nanomaterials (WPMN) Sub-groups • SG-Risk Assessment and Regulatory Programmes • SG-Testing and Assessment • SG-Exposure Measurements and Mitigation • SG-Environmental Sustainable Use
  8. 8. 8 Nanotechnology: Delivering on the Promise It is a SHARED Responsibility Working Together Company Strategy and Commitment Effective Collaborations Proportional Regulatory Actions

×