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OECD Adverse Outcome Pathways programme

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On 30 April 2019, the OECD organised a webinar on the Adverse Outcome Pathway (AOP) framework. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment. The following questions were addressed: What is the AOP framework and why should you care? Why are we developing AOPs? Why collaborations are encouraged and why should scientific societies be brought in? What are the opportunities for collaboration in AOP development?

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OECD Adverse Outcome Pathways programme

  1. 1. OECD AOP programme Nathalie Delrue, Environment Health and Safety Division, OECD Adverse Outcome Pathway (AOP) Webinar Tuesday April 30, 2019
  2. 2. Webinar on Testing and Assessment Methodologies Next generation knowledge: The Adverse Outcome Pathway framework as a collaborative tool Tuesday 30 April 2019 1 pm (CET Paris time) / 7 am (EST) Register for the webinar Send us your questions in advance at: ehs.contact@oecd.org
  3. 3. – What is the AOP framework and why should you care? – Why are we developing AOPs? – Why collaborations are encouraged and why should scientific societies be brought in? – What are the opportunities for collaboration in AOP development? Scope of the Webinar
  4. 4. • Speakers: > Nathalie Delrue (OECD Secretariat): OECD AOP Programme > Kate Willett (Humane Society International): An Introduction to AOP framework > Jason O’Brien (Environment Canada): AOP collaborative development > Dan Villeneuve (US Environmental Protection Agency): Examples of AOP application in chemical risk assessment Programme of the webinar
  5. 5. OECD AOP DEVELOPMENT PROGRAMME
  6. 6. What are AOPs? AOPs are a structured and advanced way to - manage qualitative and quantitative data, - build collective knowledge, - provide scientific support to the development of alternative methods and IATAs
  7. 7. • Introduced in 2012 • Overseen by the Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST) • Role: o develop AOP framework o coordinate development and review o provide an AOP knowledge base o support regulatory programmes o promote international uptake OECD programme on AOPs
  8. 8. Relevant tools for AOP development and assessment • Guidance Document for developing and assessing Adverse Outcome Pathways (2017) • Users' Handbook supplement to the Guidance Document (2018)
  9. 9. Guidance and training on development methodology Weighing of evidence and describing uncertainty AOP development process Assembly of knowledge based on expert collaboration Scientific review of the information
  10. 10. Effectopedia -Captures quantitative information and models -Provides standard visual representation of AOPs and associated test methods https://www.effectopedia.org/ e.AOP.Portal -Main entry point for the AOP-KB -Search engine for all AOPs -Houses the status of all AOPs & links to the official copies -Allows browsing of review reports https://aopkb.oecd.org/ AOP-Wiki -Entry level module for evaluating an AOP’s scientific evidence -Supports OECD review of AOPs -Default go-to module for all qualitative AOPs https://aopwiki.org/ IT tools: AOP-Knowledgebase (AOP-KB)
  11. 11. CONCLUDING REMARKS
  12. 12. • Broader engagement and participation of scientific societies to the AOP development, review and publication processes is key to the success of the programme! • Webinar dedicated to practical AOP development in the AOP KB in the 2nd half of 2019. • In the meantime you can contact us Concluding remarks:
  13. 13. • Adverse Outcome Pathways http://www.oecd.org/chemicalsafety/testing/adverse-outcome- pathways-molecular-screening-and-toxicogenomics.htm • Future webinar announcements / Recordings of past webinars: – Webinar Series on Testing and Assessment Methodologies http://www.oecd.org/chemicalsafety/testing/webinars-on-testing-and- assessment-methodologies.htm – Webinar Series on Emerging Science to Improve Chemical Safety http://www.oecd.org/chemicalsafety/testing/webinars-on-emerging- science.htm • Online training material https://learning.aopkb.org/ Useful links - OECD website
  14. 14. • e.AOP.Portal: https://aopkb.oecd.org/ • AOP-Wiki: https://aopwiki.org/ • Effectopedia: https://www.effectopedia.org/ Useful links – AOP Knowledge Base
  15. 15. AOP Development Programme Contact points at OECD Magdalini Sachana Magdalini.sachana@oecd.org Nathalie Delrue Nathalie.delrue@oecd.org Thank you for your attention!
  16. 16. QUESTIONS

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