On 30 April 2019, the OECD organised a webinar on the Adverse Outcome Pathway (AOP) framework. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment. The following questions were addressed: What is the AOP framework and why should you care? Why are we developing AOPs? Why collaborations are encouraged and why should scientific societies be brought in? What are the opportunities for collaboration in AOP development?

1. OECD AOP programme
Nathalie Delrue, Environment Health and Safety Division, OECD
Adverse Outcome Pathway (AOP) Webinar
Tuesday April 30, 2019

2. Webinar on Testing and Assessment
Methodologies
Next generation knowledge: The Adverse Outcome
Pathway framework as a collaborative tool
Tuesday 30 April 2019
1 pm (CET Paris time) / 7 am (EST)
Register for the webinar
Send us your questions in advance at: ehs.contact@oecd.org

3. – What is the AOP framework and why should you care?
– Why are we developing AOPs?
– Why collaborations are encouraged and why should scientific
societies be brought in?
– What are the opportunities for collaboration in AOP
development?
Scope of the Webinar

4. • Speakers:
> Nathalie Delrue (OECD Secretariat): OECD AOP Programme
> Kate Willett (Humane Society International): An Introduction
to AOP framework
> Jason O’Brien (Environment Canada): AOP collaborative
development
> Dan Villeneuve (US Environmental Protection Agency):
Examples of AOP application in chemical risk assessment
Programme of the webinar

5. OECD AOP DEVELOPMENT
PROGRAMME

6. What are AOPs?
AOPs are a structured and advanced way to
- manage qualitative and quantitative data,
- build collective knowledge,
- provide scientific support to the development of alternative methods
and IATAs

7. • Introduced in 2012
• Overseen by the Extended
Advisory Group on Molecular
Screening and Toxicogenomics
(EAGMST)
• Role:
o develop AOP framework
o coordinate development and review
o provide an AOP knowledge base
o support regulatory programmes
o promote international uptake
OECD programme on AOPs

8. Relevant tools for AOP development and assessment
• Guidance Document for
developing and assessing Adverse
Outcome Pathways (2017)
• Users' Handbook supplement to
the Guidance Document (2018)

9. Guidance and
training on
development
methodology
Weighing of
evidence and
describing
uncertainty
AOP development process
Assembly of
knowledge
based on expert
collaboration
Scientific
review of the
information

10. Effectopedia
-Captures quantitative
information and models
-Provides standard visual
representation of AOPs and
associated test methods
https://www.effectopedia.org/
e.AOP.Portal
-Main entry point for the AOP-KB
-Search engine for all AOPs
-Houses the status of all AOPs &
links to the official copies
-Allows browsing of review reports
https://aopkb.oecd.org/
AOP-Wiki
-Entry level module for evaluating an
AOP’s scientific evidence
-Supports OECD review of AOPs
-Default go-to module for all qualitative
AOPs
https://aopwiki.org/
IT tools: AOP-Knowledgebase (AOP-KB)

13. CONCLUDING REMARKS

14. • Broader engagement and participation of scientific
societies to the AOP development, review and
publication processes is key to the success of the
programme!
• Webinar dedicated to practical AOP development in the
AOP KB in the 2nd half of 2019.
• In the meantime you can contact us
Concluding remarks:

15. • Adverse Outcome Pathways
http://www.oecd.org/chemicalsafety/testing/adverse-outcome-
pathways-molecular-screening-and-toxicogenomics.htm
• Future webinar announcements / Recordings of past webinars:
– Webinar Series on Testing and Assessment Methodologies
http://www.oecd.org/chemicalsafety/testing/webinars-on-testing-and-
assessment-methodologies.htm
– Webinar Series on Emerging Science to Improve Chemical Safety
http://www.oecd.org/chemicalsafety/testing/webinars-on-emerging-
science.htm
• Online training material
https://learning.aopkb.org/
Useful links - OECD website

16. • e.AOP.Portal: https://aopkb.oecd.org/
• AOP-Wiki: https://aopwiki.org/
• Effectopedia: https://www.effectopedia.org/
Useful links – AOP Knowledge Base

17. AOP Development Programme Contact points at OECD
Magdalini Sachana
Magdalini.sachana@oecd.org
Nathalie Delrue
Nathalie.delrue@oecd.org
Thank you for your attention!

18. QUESTIONS