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Adverse Outcome Pathways Knowledge Base (AOP-KB) Introduction - Clemens Wittwehr, European Commission Joint Research Centre

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This third webinar in the series of Adverse Outcome Pathways (AOPs) was organised on Thursday 30 January 2020. It focused on the core information and telecommunication technologies applications that were built to support AOP development, management and dissemination. Tools and technical tips to facilitate scientific knowledge assembling and evaluations were also presented. The AOP framework implements a collaborative and innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment. Clemens Wittwehr from the European Commission Joint Research Centre provided an introduction on AOP-KB.

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Adverse Outcome Pathways Knowledge Base (AOP-KB) Introduction - Clemens Wittwehr, European Commission Joint Research Centre

  1. 1. AOP-KB INTRODUCTION Clemens WITTWEHR European Commission – Joint Research Centre (JRC) – Ispra, Italy
  2. 2. The Sushi analogy…
  3. 3. The Sushi analogy… Scientific Literatur e AOP-KBYOU! Volunteer s OECD
  4. 4. The AOP community of practice in reality Where do I find AOPs in real life? What is an AOP in real life? What can I do with an AOP in real life? Where do I get more information?
  5. 5. https://aopkb.oecd.org/ https://www.effectopedia.org/ https://aopwiki.org/ Third Party Tools http://apps.cytoscape.org/apps/aopxplorer Intermediate Effects Database (IEDB) • Entry level module for evaluating an AOP’s scientific evidence • Supports OECD review of AOPs • Default go-to module for all qualitative AOPs • Main entry point for the AOP-KB • Search engine for all AOPs Houses the status of all AOPs & links to the official copies • Allows browsing of review reports • Captures quantitative information and models • Provides standard visual representation of AOPs and associated test methods The AOP Knowledge Base On the Web this Summer 2020!
  6. 6. The AOP community of practice in reality Where do I find AOPs in real life?  In the AOP Knowledge Base Wiki! https://aopwiki.org What is an AOP in real life? What can I do with an AOP in real life? Where do I get more information?
  7. 7. Tour of AOP Wiki front page
  8. 8. The AOP community of practice in reality Where do I find AOPs in real life?  In the AOP Knowledge Base Wiki! https://aopwiki.org What is an AOP in real life?  A document in the Wiki What can I do with an AOP in real life? Where do I get more information?
  9. 9. AOP Page Section 1 – Title Section 2 – Authors Section 3 - Status Section 4 – Abstract Background (Optional) Section 5a – Summary of the AOP MIE KEs AO Key Event Relationships Applicability domain(s) of the AOP Life-stage Taxonomic Sex Section 7 – Overall Assessment of the AOP Modified Bradford Hill Considerations KE Pages • Description • Measurement/ detection • Taxonomic applicability AO Page • Description • Measurement/ detection • Taxonomic applicability • Regulatory relevance KER Pages • Title • Description • Biological plausibility • Empirical support • Inconsistencies and uncertainties • Quantitative understanding Linkage table MIE Page • Description • Measurement/ detection • Taxonomic applicability • Evidence for chemical initiation Chemical initiator(s) Section 8 – Considerations for Potential Applications of the AOP AOP Wiki documents
  10. 10. The AOP community of practice in reality Where do I find AOPs in real life?  In the AOP Knowledge Base Wiki! https://aopwiki.org What is an AOP in real life?  A document in the Wiki What can I do with an AOP in real life?  View online and/or Print  Comment  Edit  Review Where do I get more information?
  11. 11. • Open to anyone, no account requiredRead access • Create account, no approvals requiredCommenting • Create account (same as above) • Submit brief developer application for approval Author/write access • Help ensure consistency with published principles and OECD guidelines • Monitor the use of vocabulary (ontologies) to facilitate re-use and the creation of networks Gardener (experienced AOP developers/ wiki users) Accessing the AOP Wiki https://aopwiki.org/ http://www.saaop.org/ • AOP peer review • Volunteers needed!!!Reviewer
  12. 12. The AOP community of practice in reality Where do I find AOPs in real life?  In the AOP Knowledge Base Wiki! https://aopwiki.org What is an AOP in real life?  A document in the Wiki What can I do with an AOP in real life?  View online and/or Print  Comment  Edit  Review Where do I get more information?  On the OECD website!  Just google "OECD AOPs"
  13. 13. AOP AOP AOP AOP AOP AOPAOP AOP AOP AOP AOP AOP AOP AOP AOP AOP AOP AOP AOPAOP AOP SAAOP Entrance Gate AOP-KB write access via SAAOP AOPs from the scientific community OECD Entrance Gate AOP-KB write access via SAAOP AOPs get directly on the OECD work program AOP EAGMST check Closer look at selected AOPs Support given to authors First reality check External Review External review organised by TFHA/WNT The AOP lifecycle
  14. 14. Some numbers… 1031 registered users in the AOP Wiki, of which 163 authors
  15. 15. AOP-KB in context Test Methods Adverse Outcome Pathways Undergoes test OHT 201 Chemical triggers doesnottrigger triggers doesnottrigger inconclusiveFor example Ives C, Campia I, Wang RL, Wittwehr C, Edwards S. Creating a Structured AOP Knowledgebase via Ontology-Based Annotations. Appl In Vitro Toxicol. 2017 Dec 1;3(4):298-311. doi: 10.1089/aivt.2017.0017 Currently being implemented

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