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With improvements in our biological understating, computational power, and an ever-changing regulatory landscape, new methods for evaluating human health impact and risk are emerging. Since 2010, the Beyond Science & Decisions workshop series has provided a venue for testing, vetting, and improving novel risk assessment methods. With the collaboration of over 55 organizations representing government, industry, scientific societies, consultancies, and environmental NGOs, the series has now reviewed over 30 case studies illustrating such methods. The ARA Dose Response Framework includes these case studies and links to key guidance documents on a range of risk assessment issues. It was developed by panel members and workshop participants as a way to categorize and identify gaps in available methods, and to aid risk assessors in identifying useful tools for different problem formulations. It is intended as a tool to help guide the risk assessor in selecting an appropriate method(s) for addressing different issues related to hazard characterization and dose-response assessment, and to help the field of risk assessment identify gaps in methodology. This symposium will highlight several methods that have been presented as part of the workshop series, and then provide an interactive demonstration of the Dose Response Framework and how these methods fit within the framework. The session will then open for audience discussion on enhancements to the Framework.