3. TWO CELL TYPES
• Neuroglia –
supporting cells that
insulate, support, and
protect delicate
neurons
• Neurons – nerve cells
3
4. 4
• Ependymal cells: ciliated cells
that line cavities of the brain
and spinal cord; beating cilia
keep cerebrospinal fluid
circulating
• Astrocytes: anchor neurons to
capillaries and regulate
exchanges between them
• Oligodendrocytes: wrap around
nerve fibers to form insulating
coverings called myelin sheaths
• Microglia: phagocytes that
dispose of debris, including
dead brain cells and bacteria
• Satellite cells: protective
cushioning cells in the PNS
• Schwann cells: form myelin
sheaths in the PNS
5. ANATOMY OF A NEURON
• Dendrites: fibers that receive & convey messages to cell body
• Cell body: metabolic center of the cell; contains the nucleus
• Axon: fibers that conduct impulses away from the cell body
• Axon terminal: branching fibers at the end of the axon; contains
vesicles filled with chemicals called neurotransmitters 5
7. MYELIN SHEATH
• Some neurons have a
covering composed of a
whitish, fatty material called
myelin
• Insulates fibers and increases
the rate of transmission of the
nerve impulse
7
8. • Nerve cells outside the CNS are myelinated by Schwann
cells
• Wrap themselves around the axon
• Gaps between Schwann cells, Nodes of Ranvier, allows
impulse to jump from node to node, increasing transmission
speed
SCHWANN CELLS
Schwann cell
8
9. AXON TERMINAL
• At their terminal end, axons
branch into hundreds or
thousands of axon terminals
• Each contains vesicles or sacs
of neurotransmitters
• When a nerve impulse reaches
an axon terminal, it stimulates
the release of neurotransmitters
9
10. SYNAPSE
• Neurons do not actually
touch each other
• The junction between them
is called a synapse
• Neurotransmitters diffuse
across the synapse to
continue cell to cell
communication
10
11. BUNDLES OF NERVE FIBERS
11
• White matter –
myelinated
• Gray matter –
unmyelinated
• In PNS, they are called
nerves
• In CNS, bundles of nerve fibers are called tracts
12. STRUCTURAL CLASSIFICATION OF NEURONS
Based on the number of processes extending from the cell
body.
12
• Bipolar – have a single
dendrite and axon
• Unipolar – lack dendrites and
have a single axon
• Multipolar (most common) –
one axon and several
dendrites
13. FUNCTIONAL CLASSIFICATION OF NEURONS
• Sensory (Afferent) Neurons (green)
carry impulses from receptors (such
as the skin) to the CNS
• Interneurons (Relay Neurons)
(yellow) connect sensory and motor
neurons in the CNS
• Motor (Efferent) Neurons (purple)
carry impulses from the CNS to an
effector (muscle or gland)
13
16. PROPRIOCEPTORS
• Sensory receptors situated on
the nerve endings of the inner
ear, muscles, skin, joints,
tendons, and other tissues
• Detect stretch or tension in
skeletal muscles, tendons and
joints
• Maintain balance and posture
Micrograph of a muscle
spindle, a sensory
receptor that conveys
messages to the CNS
about body position. 16
Editor's Notes
Neuroglia (glia or glial cells) resemble neurons, but do not transmit impulses
Myelin acts as an electrical insulator which greatly increases the speed of a nerve signal
Unmyelinated axon conduction velocities range from about 0.5 to 10 m/s
Myelinated axons can conduct impulses at velocities up to 150 m/s
Source: https://www.ncbi.nlm.nih.gov/books/NBK10921/
Another feature of myelinated neurons that speeds impulse transmission is the presence of gaps between Schwann cells
These gaps, called Nodes of Ranvier, are the only sections of the axon where current flows, so the action potential actually jumps from node to node
Dendrites of sensory neurons are usually associated with specialized receptors of the sense organs or of the skin (shown), muscles and tendons
Students may recall sensory receptors in the skin include free nerve endings, Pacinian corpuscles, and Meissner’s corpuscles