Otava Institute is the leading research centre for fluorescence-based detection products and solutions that advance biomedical research and other fields of life science. Years of experience enables us to serve our customers with products of excellent quality at very competitive prices as well to participate in a number of contract research projects with European and American companies

1. Fluorescent Probes Design
Services
Research solutions for life science
www.otava.institute

2. Services
Development of near red labels and dyes for antibodies
Study of small molecules interaction with biological molecules and
binding characterization
Leading up the fluorescence-based bioassays for the detection and
evaluation of food materials, biochemical molecules and objects on
demand
Synthesis of the dyes with required amounts up to kilo scales
Having many years
experience in the field
of Fluorescent Probes
Design Otava Research
Institute offers the
comprehensive
products and services
to advance biomedical
research.

3. Design and development of fluorescent dyes with requested
characteristics for biomolecules sensing
Design of fluorescent probes and labels for the target object of
interest
Development of fluorescent assays and protocols
Development of new dyes for optical microscopy and nanoscopy
Services

4. What makes Fluorescence Design Services
different from other?
2,000 synthetic dyes collection of various classes covering the absorbance range from
350 nm to 1100 nm
Reproducible protocols of obtaining could be optimized up to the kilo scales amounts
of the product
The ready-made dyes may be prepared as derivatives bearing “universal” binding
group
Non-expensive synthesis
State-of-the-art technology and the best design processes
Own R&D resources

5. Innovative Products Open up Sales Opportunities on the
Market of Fluorescent Dyes for Biomedical Applications
NEW ORIGINAL SQUARAINE DYE
Otava Institute
Fluorescent Design
Department represents
the original new
squaraine dye for the
protein detection.
The dye is already
synthesized and ready to
use for biomedical
application
• The maximum absorption of the dye in the
presence of the protein is 639 nm
• The quantum yield of the dye in the protein
presence is 74%
• Molar Extinction Coefficient in DMSO is
24*104 M-1cm-1
• Patentable
Main properties and advantages:

6. Offering Innovative Products
TECHNOLOGY FOR SALE: DESIGN OF NEW ORANGE- AND RED- EMITTERS FOR LABELING OF BIOMOLECULES
Otava Institute represents
already synthesized dyes of
three different chemical
types as potential start point
for the development of
Fluorescent Labels for the
Antibodies.
Spectral characteristics of dyes in TRIS-HCl buffer pH 7.9 (free, with DNA, BSA) and methanol

7. Otava Research Institute Key Facts
 We are at European market since 1997
 Our team includes high-skilled stuff with excellent experience in
chemistry, biology, physics and life science
 We work for pharmaceutical, agro , cosmetic, food and material science
industries
 Our research portfolio consists of more than 172 publications, 11
patents, more than 20 completed contract research projects
 Our specialists have developed products for Sigma Aldrich

8. Citations
• M.V. Kuperman, S.V. Chernii, M.Yu. Losytskyy, D.V. Kryvorotenko, N.O. Derevyanko, Yu.L. Slominskii, V.B. Kovalska, S.M.
Yarmoluk. Trimethine cyanine dyes as fluorescent probes for amyloid fibrils: The effect of N,N’-substituents //
Analytical Biochemistry. – 2015. – V.484. – P.9-17.
• W.F. Patton, S.M. Yarmoluk, P. Pandee, V. Kovalska, L. Dai, K. Volkova, J. Coleman, M. Losytskyy, A. Ludlam, A.
Balanda, D. Shen. Dyes for Analysis of Protein Aggregation // Patent Application US2013137112 (A1) ― 2013-05-30.
• V.B. Kovalska, M.Yu. Losytskyy, O.I. Tolmachev, Yu.L. Slominskii, G.M.J. Segers-Nolten, V. Subramaniam, S.M.
Yarmoluk. Tri- and Pentamethine Cyanine Dyes for Fluorescent Detection of α-Synuclein Oligomeric Aggregates //
Journal of Fluorescence. – 2012. – V.22, Iss.6. – P.1441-1448.
• V. Kovalska, M. Losytskyy, V. Chernii, K. Volkova, I.a Tretyakova, V. Cherepanov, S. Yarmoluk, S. Volkov. Studies of anti-
fibrillogenic activity of phthalocyanines of zirconium containing out-of-plane ligands // Bioorganic & Medicinal
Chemistry. – 2012. – V20. – P.330-334.
• K.D. Volkova, V.B. Kovalska, D. Inshin, Yu.L. Slominskii, O.I. Tolmachev, S.M. Yarmoluk. Novel fluorescent trimethine
cyanine dye 7519 for amyloid fibril inhibition assay // Biotechnic and Histochemistry. – 2011, – V.86. – P.188-191.
• K.D. Volkova, V.B. Kovalska, M.Yu. Losytskyy, K.O. Fal, N.O. Derevyanko, Y.L. Slominskii, O.I. Tolmachov and S.M.
Yarmoluk. Hydroxy and Methoxy Substituted Thiacarbocyanines for Fluorescent Detection of Amyloid Formations //
Journal of Fluorescence. – 2011. – V.21. – P.775-784.

9. Please contact us:
Otava Research Institute
+38 098 991 48 13
ua@otava.institute
www.otava.institute
Research solutions for life science
Need to tag
antibody with
fluorophore?
Need a specific dye
for your
biomolecule?
Want to develop
assay kit for your
research work?