The document discusses cardiac pulmonary resuscitation (CPR) in traumatic arrest. It finds that CPR has demonstrated benefits in medical arrest but no clear benefits in traumatic arrest based on old and new research. The potential negative aspects of CPR in trauma are well-documented, including delaying necessary procedures and impairing evaluation. For traumatic arrest, the priorities are relieving tension pneumothorax, establishing airway/IV access, reversing hypovolemia, and stopping bleeding, with no role identified for CPR.
The document provides an overview of updates to the 10th edition of the Advanced Trauma Life Support (ATLS) guidelines. Key changes include a more judicious approach to fluid resuscitation, a focus on early use of blood products and management of coagulopathy, revisions to guidelines for needle thoracocentesis and management of tension pneumothorax, and emphasis on avoiding unnecessary imaging and procedures at primary hospitals to expedite transfer to definitive care facilities. The trauma team approach is highlighted throughout the new guidelines.
This document discusses principles of combat casualty care, including:
1. The goals of Tactical Combat Casualty Care (TCCC) are to save preventable deaths, prevent additional casualties, and complete the mission.
2. About 60% of combat deaths are from hemorrhage from extremity wounds, 33% from tension pneumothorax, and 6% from airway obstruction - all of which can potentially be prevented with the right interventions.
3. There are three categories of casualties on the battlefield - those who will live regardless, those who will die regardless, and those who could be saved from preventable deaths with proper medical intervention. The goal is to target interventions to the correct mechanisms
The document provides an overview and implementation guidelines for the Emergency Severity Index (ESI), a 5-level emergency department triage algorithm. It describes the levels from 1 to 5, with 1 requiring immediate life-saving intervention and 5 indicating non-urgent conditions. Factors like vital signs, high-risk conditions, and resource needs are used to assign patients to the appropriate ESI level to prioritize care. The ESI aims to standardize triage in US emergency departments.
Cardiopulmonary resuscitation (CPR) involves three key steps:
1) Assessment of the collapsed victim to determine unresponsiveness and activate emergency services.
2) Performance of chest compressions at a rate of 100-120 per minute and depth of 5-6 cm, allowing full chest recoil between compressions.
3) Use of an automated external defibrillator (AED) as soon as it is available to analyze the heart rhythm and deliver a shock if needed.
CARDIOPULMONARY RESUSCITATION- BLS & ACLS-2020 AHA UPDATEAryaDasmahapatra
This document provides information about cardiopulmonary resuscitation (CPR) and the basic life support (BLS) and advanced cardiac life support (ACLS) protocols. It begins with definitions of CPR and its purposes to support life through circulation and prevent brain damage from lack of oxygen. The history of developments in CPR techniques from chest compressions to defibrillation are outlined. Adult and pediatric BLS protocols are described, including assessing responsiveness, calling for help, performing high-quality chest compressions, opening the airway, rescue breathing, and using an automated external defibrillator. Differences in CPR for adults, children and infants are also summarized.
Ultrasound can be useful in the evaluation and diagnosis of patients presenting in shock. Integrating bedside ultrasound allows for a more accurate initial diagnosis and earlier treatment. The RUSH protocol assesses the heart, IVC, pericardial space and lungs to help classify the type of shock. Ultrasound findings of a dilated and collapsing IVC along with evidence of free fluid suggest the patient has hypovolemic shock likely due to internal bleeding.
This document discusses methods for triage and assessment in mass casualty situations. It describes evaluating patients based on airway, breathing, circulation, disability and exposure (ATLS methodology). Patients are categorized into triage categories (immediate, delayed, minimal, expectant) based on their injuries and prognosis. Scoring systems like Injury Severity Score (ISS) and Revised Trauma Score (RTS) are used to evaluate patients and compare outcomes between treatment centers using TRISS methodology.
Ultrasound confirmation of endotracheal tube placementSCGH ED CME
This document discusses using ultrasound to confirm endotracheal tube placement in emergency situations. It describes how ultrasound can be used to directly visualize the trachea and detect proper tube placement by seeing a single air-mucosal interface, or to indirectly visualize lung ventilation through pleural movement. Ultrasound is a fast, sensitive, and specific technique that does not require ventilation and can be helpful when other confirmation methods are unreliable or unavailable. However, it requires ultrasound skills and access to a machine, and is not intended to replace capnography and auscultation as the primary confirmation methods.
The document provides an overview of updates to the 10th edition of the Advanced Trauma Life Support (ATLS) guidelines. Key changes include a more judicious approach to fluid resuscitation, a focus on early use of blood products and management of coagulopathy, revisions to guidelines for needle thoracocentesis and management of tension pneumothorax, and emphasis on avoiding unnecessary imaging and procedures at primary hospitals to expedite transfer to definitive care facilities. The trauma team approach is highlighted throughout the new guidelines.
This document discusses principles of combat casualty care, including:
1. The goals of Tactical Combat Casualty Care (TCCC) are to save preventable deaths, prevent additional casualties, and complete the mission.
2. About 60% of combat deaths are from hemorrhage from extremity wounds, 33% from tension pneumothorax, and 6% from airway obstruction - all of which can potentially be prevented with the right interventions.
3. There are three categories of casualties on the battlefield - those who will live regardless, those who will die regardless, and those who could be saved from preventable deaths with proper medical intervention. The goal is to target interventions to the correct mechanisms
The document provides an overview and implementation guidelines for the Emergency Severity Index (ESI), a 5-level emergency department triage algorithm. It describes the levels from 1 to 5, with 1 requiring immediate life-saving intervention and 5 indicating non-urgent conditions. Factors like vital signs, high-risk conditions, and resource needs are used to assign patients to the appropriate ESI level to prioritize care. The ESI aims to standardize triage in US emergency departments.
Cardiopulmonary resuscitation (CPR) involves three key steps:
1) Assessment of the collapsed victim to determine unresponsiveness and activate emergency services.
2) Performance of chest compressions at a rate of 100-120 per minute and depth of 5-6 cm, allowing full chest recoil between compressions.
3) Use of an automated external defibrillator (AED) as soon as it is available to analyze the heart rhythm and deliver a shock if needed.
CARDIOPULMONARY RESUSCITATION- BLS & ACLS-2020 AHA UPDATEAryaDasmahapatra
This document provides information about cardiopulmonary resuscitation (CPR) and the basic life support (BLS) and advanced cardiac life support (ACLS) protocols. It begins with definitions of CPR and its purposes to support life through circulation and prevent brain damage from lack of oxygen. The history of developments in CPR techniques from chest compressions to defibrillation are outlined. Adult and pediatric BLS protocols are described, including assessing responsiveness, calling for help, performing high-quality chest compressions, opening the airway, rescue breathing, and using an automated external defibrillator. Differences in CPR for adults, children and infants are also summarized.
Ultrasound can be useful in the evaluation and diagnosis of patients presenting in shock. Integrating bedside ultrasound allows for a more accurate initial diagnosis and earlier treatment. The RUSH protocol assesses the heart, IVC, pericardial space and lungs to help classify the type of shock. Ultrasound findings of a dilated and collapsing IVC along with evidence of free fluid suggest the patient has hypovolemic shock likely due to internal bleeding.
This document discusses methods for triage and assessment in mass casualty situations. It describes evaluating patients based on airway, breathing, circulation, disability and exposure (ATLS methodology). Patients are categorized into triage categories (immediate, delayed, minimal, expectant) based on their injuries and prognosis. Scoring systems like Injury Severity Score (ISS) and Revised Trauma Score (RTS) are used to evaluate patients and compare outcomes between treatment centers using TRISS methodology.
Ultrasound confirmation of endotracheal tube placementSCGH ED CME
This document discusses using ultrasound to confirm endotracheal tube placement in emergency situations. It describes how ultrasound can be used to directly visualize the trachea and detect proper tube placement by seeing a single air-mucosal interface, or to indirectly visualize lung ventilation through pleural movement. Ultrasound is a fast, sensitive, and specific technique that does not require ventilation and can be helpful when other confirmation methods are unreliable or unavailable. However, it requires ultrasound skills and access to a machine, and is not intended to replace capnography and auscultation as the primary confirmation methods.
This document discusses SvO2 and ScvO2 monitoring. SvO2 measures oxygen saturation from blood in the pulmonary artery and requires a pulmonary artery catheter. It provides information about whole body oxygen utilization. A decreased SvO2 indicates increased tissue oxygen extraction, while an increased SvO2 demonstrates decreased extraction and adequate cardiac output to meet tissue needs. ScvO2 can be used as a surrogate for SvO2. Monitoring SvO2/ScvO2 can help guide resuscitation and understand if oxygen delivery meets demand, but risks are associated with pulmonary artery catheters and values must be interpreted in clinical context.
The document summarizes key changes in the 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. It thanks contributors and provides an introduction. Major changes included in the adult basic and advanced life support section are emphasized, such as enhanced algorithms, early CPR and epinephrine administration, monitoring CPR quality, and improved post-cardiac arrest care. New recommendations are highlighted regarding various resuscitation practices.
1) Shock is defined as inadequate tissue perfusion resulting from low blood pressure and abnormal cellular metabolism. The main types of shock are hypovolemic, distributive, and cardiogenic.
2) Hypovolemic shock occurs when intravascular volume is decreased, such as from blood loss, and requires fluid resuscitation. Septic shock, a form of distributive shock, involves infection and organ dysfunction and responds to antibiotics, fluids, and vasopressors.
3) Cardiogenic shock results from heart failure or damage and presents with low output and adequate fluid levels. It may be treated with inotropes, vasopressors, and procedures like LVAD or transplant
Damage Control Resuscitation (DCR) is a systematic approach for managing major trauma patients at risk of exsanguinating hemorrhage. It incorporates permissive hypotension to minimize blood loss while hemorrhage is uncontrolled, haemostatic resuscitation using blood products instead of crystalloids to prevent coagulopathy, and early hemorrhage control through surgery. DCR aims to decrease mortality and morbidity by recognizing patients at risk of hemorrhagic shock, providing adequate tissue oxygenation through hypotensive resuscitation while limiting further blood loss and clot disruption, and preventing the triad of hypothermia, acidosis and coagulopathy through haemostatic resuscitation and blood product administration according to a
The document discusses the use of high flow nasal cannula (HFNC) oxygen therapy. It presents findings from several studies that show HFNC can increase apnea times in patients with difficult airways, may reduce the need for intubation and improve mortality in abnormal lungs, and can reduce hypoxemia in ICU patients. However, one study found no difference in preoxygenation when comparing HFNC to a face mask. The document recommends using HFNC in the ED for comfort in patients with hypoxia/respiratory distress, for apneic oxygenation during brief procedures in those at risk, and for mild respiratory distress and hypoxia where intubation and NIV may not be needed.
The document outlines guidelines for Basic Life Support (BLS) and Advanced Cardiovascular Life Support (ACLS) presented by interns at KIMS, BBSR. It discusses BLS guidelines including CPR technique and choking, and provides ACLS algorithms. Key aspects of BLS covered are assessing carotid pulse, initiating chest compressions if no pulse, and reassessing after 2 minutes of CPR. ACLS algorithms outlined include those for adult cardiac arrest, post-cardiac arrest care, tachycardia, and bradycardia. Identifying unstable patients using HASIA criteria is also summarized.
The document provides guidelines on the assessment and management of trauma patients in the pre-hospital setting. It emphasizes maintenance of airway, breathing, and circulation as top priorities, with rapid transport to a trauma center. Diagnostic techniques like focused assessment with sonography for trauma (FAST) exam and indications for intubation are outlined. Triage systems like revised trauma score (RTS) and injury severity score (ISS) are also summarized for evaluating patients and comparing outcomes.
The document outlines the teaching protocol for Advanced Trauma Life Support (ATLS). It includes:
1. A pretest, context tutorial covering general principles and specific trauma types, and post-test.
2. Skills stations covering airway management, immobilization, and resuscitation adjuncts.
3. The in-hospital phase follows an organized approach including preparation, triage, primary and secondary surveys, monitoring, and reevaluation. It emphasizes treating life threats like airway, breathing, circulation issues before making a diagnosis.
This document provides an overview of several ICU scoring systems used to evaluate severity of illness and predict outcomes in critically ill patients. It describes the components and scoring of systems such as APACHE, SAPS, SOFA, MODS, and LODS. APACHE uses physiological variables and chronic health factors to calculate mortality risk. SAPS and SAPS II similarly assess physiology but also include age and admission type. SOFA evaluates degree of organ dysfunction in six organ systems. MODS and LODS also score dysfunction across multiple organ systems based on laboratory and clinical findings.
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
Airway management in the Emergency Department for TraineesBishan Rajapakse
This is a power point presentation on Airway Management given by our deputy director in Emergency Medicine Training at the Wollongong Hospital, Paul Labana (consultant Emergency Physician) that presents a case illustrating difficulties in airway management and gives an overview of airway management in the emergency department. (Nb another video to do with airway management, and "airway exchange" can be found on this link http://youtu.be/6vaWNknIDQg) - thanks to Paul for sharing his educational material in the name of free open access meducation (#FOAMed)
This document provides guidance on intensive care medicine topics that may be covered in the FRCA exam, with a focus on acute liver failure and cardiogenic shock. It discusses 20 specific ICU questions that may appear in the MCQ section and advises candidates to focus on structure in their answers. Example cases are presented on acute liver failure and a postoperative patient with cardiogenic shock, with discussion points provided for each. Key topics in the management of these conditions like encephalopathy, fluid balance and inotropes are reviewed. Candidates are encouraged to answer just the question asked and not provide irrelevant extra details.
Advanced trauma and life support (atls)anu_sandhya
The document outlines the steps of the Advanced Trauma Life Support (ATLS) protocol for assessing and treating multiply injured patients, including performing a primary and secondary survey to evaluate the airway, breathing, circulation, disability, and exposure of patients and providing resuscitation and monitoring before delivering definitive care. It emphasizes following the ABCDE approach to treat the greatest threats to life first and stabilizing patients before making a definitive diagnosis.
3. initial assessment and triage in er pptGirish Kumar
The document discusses the initial assessment and triage of pediatric patients in the emergency room. It outlines the goals of a triage system to rapidly assess patients and prioritize care based on acuity and severity of illness. The pediatric triage assessment involves a rapid 3-5 minute evaluation using the Pediatric Assessment Triangle (PAT) and ABCDE approach to primary assessment. The PAT evaluates appearance, breathing, and circulation within 30-40 seconds to identify life-threatening issues. Patients are then classified into 5 levels of triage acuity from resuscitation to non-urgent to prioritize treatment.
Mechanisms of cerebral injury and cerebral protectionDr Kumar
This document discusses mechanisms of cerebral injury and cerebral protection. It provides details on cerebral physiology including metabolism, blood flow, regulation of blood flow, and factors that influence blood flow such as perfusion pressure, autoregulation, respiratory gas tensions, temperature, viscosity, and autonomic influences. It also discusses intracranial pressure, signs of increased ICP, assessment of injury severity, and strategies and principles for cerebral protection including maintaining oxygen supply and reducing increases in ICP, cerebral metabolic rate, and cell damage. The effects of various anesthetic drugs on cerebral blood flow, metabolism, and injury are also summarized.
Peter McCanny is part of the LearnECMO team. In this podcast he explains some of the background and history of ECMO CPR, what evidence there is to support its use and where we're heading in the future.
This document discusses clinical audits in anaesthesia. It defines clinical audits as quality improvement processes that systematically review care against criteria to improve outcomes. The document outlines the history of audits dating back to Florence Nightingale. It describes different types of audits including clinical, critical event, outcome, training, and survey audits. The audit cycle is also explained as preparing criteria, measuring performance, implementing improvements, and sustaining changes. Barriers to audits are a lack of resources, expertise, and leadership. Audits aim to improve standards but challenges include support, time constraints, and obtaining consent.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
This document discusses SvO2 and ScvO2 monitoring. SvO2 measures oxygen saturation from blood in the pulmonary artery and requires a pulmonary artery catheter. It provides information about whole body oxygen utilization. A decreased SvO2 indicates increased tissue oxygen extraction, while an increased SvO2 demonstrates decreased extraction and adequate cardiac output to meet tissue needs. ScvO2 can be used as a surrogate for SvO2. Monitoring SvO2/ScvO2 can help guide resuscitation and understand if oxygen delivery meets demand, but risks are associated with pulmonary artery catheters and values must be interpreted in clinical context.
The document summarizes key changes in the 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. It thanks contributors and provides an introduction. Major changes included in the adult basic and advanced life support section are emphasized, such as enhanced algorithms, early CPR and epinephrine administration, monitoring CPR quality, and improved post-cardiac arrest care. New recommendations are highlighted regarding various resuscitation practices.
1) Shock is defined as inadequate tissue perfusion resulting from low blood pressure and abnormal cellular metabolism. The main types of shock are hypovolemic, distributive, and cardiogenic.
2) Hypovolemic shock occurs when intravascular volume is decreased, such as from blood loss, and requires fluid resuscitation. Septic shock, a form of distributive shock, involves infection and organ dysfunction and responds to antibiotics, fluids, and vasopressors.
3) Cardiogenic shock results from heart failure or damage and presents with low output and adequate fluid levels. It may be treated with inotropes, vasopressors, and procedures like LVAD or transplant
Damage Control Resuscitation (DCR) is a systematic approach for managing major trauma patients at risk of exsanguinating hemorrhage. It incorporates permissive hypotension to minimize blood loss while hemorrhage is uncontrolled, haemostatic resuscitation using blood products instead of crystalloids to prevent coagulopathy, and early hemorrhage control through surgery. DCR aims to decrease mortality and morbidity by recognizing patients at risk of hemorrhagic shock, providing adequate tissue oxygenation through hypotensive resuscitation while limiting further blood loss and clot disruption, and preventing the triad of hypothermia, acidosis and coagulopathy through haemostatic resuscitation and blood product administration according to a
The document discusses the use of high flow nasal cannula (HFNC) oxygen therapy. It presents findings from several studies that show HFNC can increase apnea times in patients with difficult airways, may reduce the need for intubation and improve mortality in abnormal lungs, and can reduce hypoxemia in ICU patients. However, one study found no difference in preoxygenation when comparing HFNC to a face mask. The document recommends using HFNC in the ED for comfort in patients with hypoxia/respiratory distress, for apneic oxygenation during brief procedures in those at risk, and for mild respiratory distress and hypoxia where intubation and NIV may not be needed.
The document outlines guidelines for Basic Life Support (BLS) and Advanced Cardiovascular Life Support (ACLS) presented by interns at KIMS, BBSR. It discusses BLS guidelines including CPR technique and choking, and provides ACLS algorithms. Key aspects of BLS covered are assessing carotid pulse, initiating chest compressions if no pulse, and reassessing after 2 minutes of CPR. ACLS algorithms outlined include those for adult cardiac arrest, post-cardiac arrest care, tachycardia, and bradycardia. Identifying unstable patients using HASIA criteria is also summarized.
The document provides guidelines on the assessment and management of trauma patients in the pre-hospital setting. It emphasizes maintenance of airway, breathing, and circulation as top priorities, with rapid transport to a trauma center. Diagnostic techniques like focused assessment with sonography for trauma (FAST) exam and indications for intubation are outlined. Triage systems like revised trauma score (RTS) and injury severity score (ISS) are also summarized for evaluating patients and comparing outcomes.
The document outlines the teaching protocol for Advanced Trauma Life Support (ATLS). It includes:
1. A pretest, context tutorial covering general principles and specific trauma types, and post-test.
2. Skills stations covering airway management, immobilization, and resuscitation adjuncts.
3. The in-hospital phase follows an organized approach including preparation, triage, primary and secondary surveys, monitoring, and reevaluation. It emphasizes treating life threats like airway, breathing, circulation issues before making a diagnosis.
This document provides an overview of several ICU scoring systems used to evaluate severity of illness and predict outcomes in critically ill patients. It describes the components and scoring of systems such as APACHE, SAPS, SOFA, MODS, and LODS. APACHE uses physiological variables and chronic health factors to calculate mortality risk. SAPS and SAPS II similarly assess physiology but also include age and admission type. SOFA evaluates degree of organ dysfunction in six organ systems. MODS and LODS also score dysfunction across multiple organ systems based on laboratory and clinical findings.
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
Airway management in the Emergency Department for TraineesBishan Rajapakse
This is a power point presentation on Airway Management given by our deputy director in Emergency Medicine Training at the Wollongong Hospital, Paul Labana (consultant Emergency Physician) that presents a case illustrating difficulties in airway management and gives an overview of airway management in the emergency department. (Nb another video to do with airway management, and "airway exchange" can be found on this link http://youtu.be/6vaWNknIDQg) - thanks to Paul for sharing his educational material in the name of free open access meducation (#FOAMed)
This document provides guidance on intensive care medicine topics that may be covered in the FRCA exam, with a focus on acute liver failure and cardiogenic shock. It discusses 20 specific ICU questions that may appear in the MCQ section and advises candidates to focus on structure in their answers. Example cases are presented on acute liver failure and a postoperative patient with cardiogenic shock, with discussion points provided for each. Key topics in the management of these conditions like encephalopathy, fluid balance and inotropes are reviewed. Candidates are encouraged to answer just the question asked and not provide irrelevant extra details.
Advanced trauma and life support (atls)anu_sandhya
The document outlines the steps of the Advanced Trauma Life Support (ATLS) protocol for assessing and treating multiply injured patients, including performing a primary and secondary survey to evaluate the airway, breathing, circulation, disability, and exposure of patients and providing resuscitation and monitoring before delivering definitive care. It emphasizes following the ABCDE approach to treat the greatest threats to life first and stabilizing patients before making a definitive diagnosis.
3. initial assessment and triage in er pptGirish Kumar
The document discusses the initial assessment and triage of pediatric patients in the emergency room. It outlines the goals of a triage system to rapidly assess patients and prioritize care based on acuity and severity of illness. The pediatric triage assessment involves a rapid 3-5 minute evaluation using the Pediatric Assessment Triangle (PAT) and ABCDE approach to primary assessment. The PAT evaluates appearance, breathing, and circulation within 30-40 seconds to identify life-threatening issues. Patients are then classified into 5 levels of triage acuity from resuscitation to non-urgent to prioritize treatment.
Mechanisms of cerebral injury and cerebral protectionDr Kumar
This document discusses mechanisms of cerebral injury and cerebral protection. It provides details on cerebral physiology including metabolism, blood flow, regulation of blood flow, and factors that influence blood flow such as perfusion pressure, autoregulation, respiratory gas tensions, temperature, viscosity, and autonomic influences. It also discusses intracranial pressure, signs of increased ICP, assessment of injury severity, and strategies and principles for cerebral protection including maintaining oxygen supply and reducing increases in ICP, cerebral metabolic rate, and cell damage. The effects of various anesthetic drugs on cerebral blood flow, metabolism, and injury are also summarized.
Peter McCanny is part of the LearnECMO team. In this podcast he explains some of the background and history of ECMO CPR, what evidence there is to support its use and where we're heading in the future.
This document discusses clinical audits in anaesthesia. It defines clinical audits as quality improvement processes that systematically review care against criteria to improve outcomes. The document outlines the history of audits dating back to Florence Nightingale. It describes different types of audits including clinical, critical event, outcome, training, and survey audits. The audit cycle is also explained as preparing criteria, measuring performance, implementing improvements, and sustaining changes. Barriers to audits are a lack of resources, expertise, and leadership. Audits aim to improve standards but challenges include support, time constraints, and obtaining consent.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
2. AGENDA
• What is CPR?
• Does CPR help in traumatic arrest?
• Does CPR hurt in traumatic arrest?
• What’s the deal with traumatic arrest?
CPR IN TRAUMA
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
3. CPR
• Closed cardiac massage
• For medical cardiac arrest
• Euvolemia
CPR IN TRAUMA
WHAT IS CPR?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
41. MORE CPR DOWNSIDES
• Delay necessary procedures
• Impair primary and secondary evaluation
• Put health care workers at risk
• Decrease diastolic pressure
CPR IN TRAUMA
DOES IT HURT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
42. CPR: HELP OR HURT?
CPR IN TRAUMA
DOES IT HURT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
44. CPR: HELP OR HURT?
CPR IN TRAUMA
DOES IT HURT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
45. TRAUMATIC ARREST - NOW
WHAT?
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
46. TRAUMATIC ARREST - NUANCES
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
47. TRAUMATIC ARREST - NUANCES
Shock and arrest in the setting of trauma is
hemorrhagic until proven otherwise
It is possible to have a medical arrest and then a
subsequent trauma
Syncopal fall
MVC
The single greatest predictor of survival is time to
hemorrhage control
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
48. TRAUMATIC ARREST - NUANCES
CPR has no role in penetrating trauma
CPR might have a possible, small, secondary role
in blunt trauma in specific settings associated with
age, comorbidities and mechanism
CPR should be deprioritized in favor of more trauma-
specific interventions
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
49. TRAUMATIC ARREST - PRIORITIES
Relieve tension pneumothorax
Establish airway/ iv access
Reverse hypovolemia
STOP THE BLEED
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
50. STOPPING THE BLEED
Manual Compression
Tourniquet
Surgery
Angiography
ED Thoracotomy
REBOA
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
51. STOPPING THE BLEED
Manual Compression
Tourniquet
Surgery
Angiography
ED Thoracotomy
REBOA
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
53. STOPPING THE BLEED
Manual Compression
Tourniquet
Surgery
Angiography
ED Thoracotomy
REBOA
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
75. TRAUMATIC ARREST - PRIORITIES
Relieve tension pneumothorax
Establish airway/ iv access
Reverse hypovolemia
STOP THE BLEED
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
76. TRAUMATIC ARREST - PRIORITIES
Relieve tension pneumothorax
Establish airway/ iv access
Reverse hypovolemia
STOP THE BLEED
NO ROLE FOR CPR
CPR IN TRAUMA
SO… NOW WHAT?
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
77. CPR IN TRAUMA?
What is CPR?
Does CPR help in traumatic arrest?
Does CPR hurt in traumatic arrest?
What’s the deal with traumatic arrest?
CPR IN TRAUMA
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
78. CPR IN TRAUMA?
Demonstrated benefit in medical arrest
Does CPR help in traumatic arrest?
Does CPR hurt in traumatic arrest?
What’s the deal with traumatic arrest?
CPR IN TRAUMA
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
79. CPR IN TRAUMA?
Demonstrated benefit in medical arrest
Old & new research: no benefit in trauma
Does CPR hurt in traumatic arrest?
What’s the deal with traumatic arrest?
CPR IN TRAUMA
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
80. CPR IN TRAUMA?
Demonstrated benefit in medical arrest
Old & new research: no benefit in trauma
Negative aspects of CPR well-documented
What’s the deal with traumatic arrest?
CPR IN TRAUMA
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
81. CPR IN TRAUMA?
Demonstrated benefit in medical arrest
Old & new research: no benefit in trauma
Negative aspects of CPR well-documented
Traumatic arrest requires different priorities
CPR IN TRAUMA
#CPRinTrauma
@shaikh_mf
@FresnoTrauma
The formalised system of chest compression was really an accidental discovery made in 1958 by William Bennett Kouwenhoven, Guy Knickerbocker, and James Jude at Johns Hopkins University.[11] They were studying defibrillation in dogs when they noticed that by forcefully applying the paddles to the chest of the dog, they could achieve a pulse in the femoral artery. Further meticulous experimentation involving dogs answered such basic questions as how fast to press, where to press, and how deep to press. This information gave them the belief that they were ready for human trials.
Maryland Medical Society meeting on September 16, 1960 in Ocean City
Acosta P et al. Resuscitation great. Kouwenhoven, Jude and Knickerbocker: The introduction of defibrillation and external chest compressions into modern resuscitation. Resuscitation. 2005 Feb;64(2):139-43.
3 adult baboons, femoral arterial and femoral vein catheters; thoracotomy pericardial drain placed; first tamponade then hypovolemia and then barbituate overdose
6 dogs/ group, . Under anesthesia, dogs were hemorrhaged until pulse was lost; they were maintained pulseless for 30 minutes and then resuscitated over 20 minutes. Vital signs and laboratory values were recorded at determined intervals. Echocardiography was performed throughout the study. Upon termination of the study, kidney, liver, heart, and brain tissue histology was evaluated for end organ damage
6 dogs/ group, . Under anesthesia, dogs were hemorrhaged until pulse was lost; they were maintained pulseless for 30 minutes and then resuscitated over 20 minutes. Vital signs and laboratory values were recorded at determined intervals. Echocardiography was performed throughout the study. Upon termination of the study, kidney, liver, heart, and brain tissue histology was evaluated for end organ damage
6 dogs/ group, . Under anesthesia, dogs were hemorrhaged until pulse was lost; they were maintained pulseless for 30 minutes and then resuscitated over 20 minutes. Vital signs and laboratory values were recorded at determined intervals. Echocardiography was performed throughout the study. Upon termination of the study, kidney, liver, heart, and brain tissue histology was evaluated for end organ damage
6 dogs/ group, . Under anesthesia, dogs were hemorrhaged until pulse was lost; they were maintained pulseless for 30 minutes and then resuscitated over 20 minutes. Vital signs and laboratory values were recorded at determined intervals. Echocardiography was performed throughout the study. Upon termination of the study, kidney, liver, heart, and brain tissue histology was evaluated for end organ damage
6 dogs/ group, . Under anesthesia, dogs were hemorrhaged until pulse was lost; they were maintained pulseless for 30 minutes and then resuscitated over 20 minutes. Vital signs and laboratory values were recorded at determined intervals. Echocardiography was performed throughout the study. Upon termination of the study, kidney, liver, heart, and brain tissue histology was evaluated for end organ damage
39 white pigs; 7 pigs per group, hemorrhage model;
39 white pigs; 7 pigs per group, hemorrhage model;
39 white pigs; 7 pigs per group, hemorrhage model;
39 white pigs; 7 pigs per group, hemorrhage model;
39 white pigs; 7 pigs per group, hemorrhage model;
39 white pigs; 7 pigs per group, hemorrhage model;