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HUMAN
NUTRITION
Science For Healthy Living
Second Edition
Tammy J. Stephenson, PhD
University of Kentucky
Wendy J. Schiff, MS, RDN
© 2019 McGraw-Hill Education. All rights reserved. Authorized only for instructor use in the classroom. No reproduction or further distribution permitted without the prior written consent of McGraw-Hill Education.
© 2019 McGraw-Hill Education
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Chapter 4
Human Digestion, Absorption,
and Transport
Lecture Outline
© 2019 McGraw-Hill Education
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4.1 Overview of the
Digestive System
Learning Outcomes
1. Identify the major components of the digestive
system and the major functions of each component.
2. Describe the distinct layers of the gastrointestinal
tract wall.
3. Identify the location, anatomical name, and function
of each sphincter involved in the digestive system.
4. Explain the differences between chemical and
mechanical digestion.
© 2019 McGraw-Hill Education
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Roles of the Digestive System
The primary roles of the digestive system are:
• The breakdown of food into nutrients
• Absorption of nutrients
• Elimination of solid waste products
Digestion is the process of breaking down large
food molecules into nutrients that the body can use
Absorption is the uptake and removal of nutrients
from the digestive tract (gastrointestinal tract),
alimentary canal, or gut
© 2019 McGraw-Hill Education
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Components of the Digestive System
The digestive system has
two major components:
• GI tract
• Hollow, muscular tube
• Accessory organs
• Assist functioning of GI tract
Jump to long description
© 2019 McGraw-Hill Education
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The Wall of the GI Tract1
The wall of the GI tract has distinct layers:
• Mucosa
• Innermost layer of the digestive tract wall
• Mucus, a watery slippery fluid, is secreted from special
cells here
• Surrounds the lumen, a hollow space through which food and
fluids can pass
• Muscular layer
• Circular
• Longitudinal
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The Wall of the GI Tract2
By relaxing and
contracting, the
muscles can:
• Mix substances in
the lumen
• Control movement
of material through
the tract
© 2019 McGraw-Hill Education
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Muscle Layers of the Stomach
The wall of the
stomach is the
thickest and
strongest of the GI
tract
• Third type of
muscle, diagonal
muscle
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Sphincters Control the Flow of
GI Contents
Sphincters - thickened regions of circular muscle
that control the flow of contents at various
points in the GI tract
• When contracted:
• Passageway closed
• Flow is restricted
Essential for normal digestion and absorption
© 2019 McGraw-Hill Education
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Two GI Tract Sphincters
Jump to long description
© 2019 McGraw-Hill Education
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Mechanical and Chemical Digestion
Mechanical digestion - the physical treatments
that food undergoes while it is in the intestinal
tract
Chemical digestion - the breakdown of large
molecules in food into smaller components,
primarily by the action of stomach acid and
various enzymes, proteins that speed up the
rate of a chemical reaction without being
altered in the process
© 2019 McGraw-Hill Education
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Assess Your Progress 4.1
1. List the primary and accessory components
of the GI tract.
2. What is a sphincter?
3. Explain the difference between mechanical
and chemical digestion.
4. What is a hydrolytic enzyme?
© 2019 McGraw-Hill Education
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4.2 The Mouth
Learning Outcomes
1. Describe the mechanical and chemical digestion
that occurs in the mouth.
2. Identify and explain the effects of smell and taste
disorders in humans.
© 2019 McGraw-Hill Education
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Digestion Starts in the Mouth
Oral cavity is another term for mouth
• Digestion starts here
Teeth masticate food
• Prepares food for swallowing and chemical digestion
Tongue helps direct food into the pharynx, the
section of alimentary canal that connects the
nasal cavity with the top of the esophagus
© 2019 McGraw-Hill Education
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Salivary Glands1
Salivary glands - structures that produce saliva
and secrete the fluid in the oral cavity
Saliva - the watery fluid that contains mucus and
a few enzymes
• Lysozyme - enzyme in saliva that can destroy some
bacteria that are in food or the mouth
• Salivary amylase - enzyme in saliva that begins
starch digestion
• Lingual Lipase - enzyme secreted in saliva that
begins fat digestion
© 2019 McGraw-Hill Education
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Salivary Glands2
© 2019 McGraw-Hill Education
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Taste Buds
Taste buds have
specialized cells that
help distinguish five
basic tastes:
• Sweet
• Sour
• Salty
• Bitter
• Umami
© 2019 McGraw-Hill Education
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Sense of Smell
The sense of smell
(olfaction) contributes
to the ability to taste
food
Airborne chemicals in
chewed food stimulate
the olfactory region of
the nasal passages
© 2019 McGraw-Hill Education
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Disorders of Taste and Smell
Anosmia - the complete inability to detect odors
Hypogeusia - the diminished ability to taste
substances
Ageusia - the total loss of the ability to taste
substances
© 2019 McGraw-Hill Education
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Assess Your Progress 4.2
5. Explain what normally happens to a piece of
food that enters the mouth.
6. Identify the key components of saliva.
7. List the taste sensations that human taste
buds detect.
8. Discuss disorders of taste and smell, including
their causes.
© 2019 McGraw-Hill Education
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4.3 The Esophagus
Learning Outcomes
1. Describe the action of swallowing and what it
accomplishes.
2. Identify the muscular activity that propels a mass of
food through the esophagus.
3. Explain what happens when someone is choking on
food and demonstrate the first aid techniques
employed to save the person’s life.
4. Identify the two esophageal sphincters and their
functions.
© 2019 McGraw-Hill Education
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The Esophagus
After being swallowed, the food bolus travels
through the esophagus
• Muscular tube that extends about 10 inches from
the pharynx to the upper portion of the stomach
• Entrance is near the larynx and opening of trachea
© 2019 McGraw-Hill Education
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What Happens When You Swallow
The epiglottis is a flap of tough tissue that prevents the
food from entering the larynx and trachea
Jump to long description
© 2019 McGraw-Hill Education
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First Aid for Choking
Jump to long description
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Peristalsis
Peristalsis - waves of
muscular
contractions that
help move material
through most of the
digestive tract
• Involuntary response
© 2019 McGraw-Hill Education
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Esophageal Sphincters
Upper esophageal sphincter
(UES) - the region of the upper
part of the esophagus that
opens to allow a mass of food
to enter the esophagus
Lower esophageal sphincter
(LES) - the region of the lower
part of the esophagus that
controls flow of material into
the upper part of the stomach
• Gastroesophageal sphincter
• Prevents backflow of stomach
contents
Jump to long description
© 2019 McGraw-Hill Education
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Assess Your Progress 4.3
9. Describe peristalsis. Explain how peristalsis in
the esophagus transfers a bolus of food from
the throat to the stomach.
10.Explain why choking can occur while eating.
What should you do to save a choking
person’s life?
11.What normally keeps stomach contents from
reentering the esophagus?
© 2019 McGraw-Hill Education
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4.4 The Stomach
Learning Outcomes
1. Identify the types of cells in the gastric glands and
what each secretes.
2. Describe the kinds of mechanical and chemical
digestion that occur in the stomach.
3. List the components of gastric juice.
4. Discuss factors that influence stomach emptying.
© 2019 McGraw-Hill Education
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Secretions of the Stomach1
The stomach is a muscular sac that stores and
mixes food
Gastric glands located in the stomach synthesize
and secrete gastric juice
• A collection of stomach secretions that includes
mucus, hydrochloric acid, intrinsic factor, and
digestive enzymes
Mucous cells secret mucin, a carbohydrate-rich
substance that forms mucus when combined
with water
© 2019 McGraw-Hill Education
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Secretions of the Stomach2
Parietal cells secrete hydrogen and chloride ions, which
form hydrochloric acid (HCl) and intrinsic factor
• Intrinsic factor is a substance necessary for absorbing
vitamin B‒12
Chief cells secrete gastric lipase and some chemically
inactive digestive enzymes like pepsinogen
G cells secrete gastrin, a hormone that stimulates
stomach motility and gastric gland secretions
• Hormones are chemical messengers that convey information
to target cells
© 2019 McGraw-Hill Education
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Gastric Gland and Its Secretory Cells
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Gastric Gland Cells
Gastric Gland Cells Secretion Major Functions
Mucous Mucus Protects stomach mucosa
from HCl and enzymes
Parietal Components that form
HCl (hydrogen ions [H+]
and chloride ions [Cl-])
Intrinsic factor
Activates pepsinogen,
destroys many food-borne
microbes
Facilitates the absorption of
vitamin B-12
Chief Pepsinogen
Gastric lipase
Digests protein after
conversion to pepsin
Digests small amount of fat
G cell Gastrin Stimulates stomach motility
and gastric gland activity
© 2019 McGraw-Hill Education
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Lower Portion of the Stomach
The main function of the lower portion of the
stomach is mixing food with gastric juice to form
chyme, a semiliquid mass
The pyloric sphincter regulates the flow of
chyme into the small intestine
© 2019 McGraw-Hill Education
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Digestion in the Stomach
The presence of food in the stomach stimulates
peristalsis
• Mixes food with gastric juices
• Some protein and fat is broken down
Few substances are absorbed in the stomach
HCl contributes to low pH of gastric juice
• Acidic solutions have a pH value lower than 7
• pH of chyme is 2.0
• Alkaline solutions have a pH value higher than 7
© 2019 McGraw-Hill Education
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pH Scale
Lemon and Wine: ©Brand X Pictures/Getty Images RF; Cola: ©FoodCollection/StockFood RF; Tomato and Banana:
©Stockbyte/Getty Images RF; Coffee: ©Fuse/Getty Images RF; Milk: ©McGraw-Hill Education. Bob Coyle, photographer; Egg:
©Siede Preis/Getty Images RF; Household items: ©McGraw-Hill Education. Stephen Frisch, photographer; Ammonia:
©McGraw-Hill Education. Jacques Cornell, photographer; Oven cleaner: ©McGraw-Hill Education. Ken Karp, photographer
Jump to long description
© 2019 McGraw-Hill Education
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Acid in the Stomach
Acidic environment of stomach causes:
• Salivary amylase to cease
• Lingual lipase to become active
• Pepsinogen to be converted to pepsin, which begins the
enzymatic digestion of protein
Mucus is a slippery secretion that protects the stomach
from being damaged by its acid and digestive enzymes
• Produced by mucous cells
• If the layer of mucus breaks down, HCl and gastric enzymes
contact the stomach wall and gastric or peptic ulcers can form
© 2019 McGraw-Hill Education
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Stomach Emptying
Stomach empties in about 4 hours following a
meal
• Varies with contents and size of meal
Dumping syndrome - a disorder that occurs when
chyme flows too rapidly into the small intestine
• Often occurs after surgeries of the esophagus or
stomach
• Changing the types of food eaten (fewer sugary
foods), eating smaller meals, and taking certain
medications may help
© 2019 McGraw-Hill Education
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Assess Your Progress 4.4
12.Identify the four different gastric gland cells
and the secretions they produce.
13.Describe the digestive processes that occur
in the stomach.
14.Explain how the stomach protects itself from
digestion. What conditions might occur if this
protection fails?
15.List factors that influence stomach emptying.
© 2019 McGraw-Hill Education
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4.5 The Small Intestine
Learning Outcomes
1. Identify the three primary digestive sections of the
small intestine.
2. Describe the functions of the digestive system’s
accessory organs.
3. Discuss the functions of intestinal villi.
4. Compare and contrast the ways nutrients may be
absorbed.
© 2019 McGraw-Hill Education
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Parts of the Small Intestine1
The small intestine has three sections:
• Duodenum - first segment of the small intestine
• Jejunum - middle segment of the small intestine
• Ileum - last segment of the small intestine
Chyme moves out of the ileum into the large
intestine, passing through the ileocecal
sphincter, which controls the rate that ileum
contents empty into the large intestine
© 2019 McGraw-Hill Education
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Parts of the Small Intestine2
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Accessory Organs1
The liver, gallbladder, and pancreas are
accessory organs of the gastrointestinal system
• Chyme does not
pass through them
• Play a major role in
digestion
© 2019 McGraw-Hill Education
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Accessory Organs2
The liver:
• Processes and stores many nutrients
• Synthesizes cholesterol
• Makes bile, a greenish-yellow, bitter-tasting fluid
stored in the gallbladder until it is needed for fat
digestion and absorption
The gallbladder stores and concentrates bile
The pancreas produces and secretes digestive
enzymes and bicarbonate ions to neutralize
acidic chyme when it enters the duodenum
© 2019 McGraw-Hill Education
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Digestion in the Small Intestine
The small intestine is the major site of chemical and
mechanical digestion
• Enzyme activity
• Peristalsis
• Segmentation - regular contractions of circular intestinal
muscles followed by relaxations that mix chyme within a
short portion of the small intestine
© 2019 McGraw-Hill Education
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Major Pancreatic and Intestinal Enzymes
Enzyme Source Action
Pancreatic amylase Pancreas Digests starch
Pancreatic lipase Pancreas Digests fat
Trypsin, chymotrypsin Pancreas Partially digest proteins
Carboxypeptidase Pancreas Breaks down certain
partially digested proteins
Nuclease Pancreas Digests DNA and RNA into
nucleotides
Peptidase Small intestine Breaks down certain
partially digested proteins
Sucrase, maltase, lactase Small intestine Break down certain sugars
into simpler sugars
Intestinal lipase Small intestine Digests fat
© 2019 McGraw-Hill Education
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Villi and Surface Area
Villi - tiny, fingerlike projections of the small intestinal
mucosa that are involved in digestion and nutrient
absorption
• Cover the folds of the mucosa of the small intestine
• Enterocytes - absorptive cells that form the outer layer of a
villus
The end of the enterocyte exposed to chyme contains
microvilli, tiny, hairlike projections that form the brush
border of an enterocyte
• Contain brush border enzymes that help digest protein and
carbohydrates
© 2019 McGraw-Hill Education
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Small Intestinal Absorption
Villi are absorptive structures
Enterocytes remove nutrients from chyme and
enable them to enter the intestinal blood or
lymph vessels
© 2019 McGraw-Hill Education
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Nutrient Absorption
Nutrient absorption
can occur by:
• Simple diffusion
• Facilitated diffusion
• Active transport
• Osmosis
• Endocytosis
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Core of the Villus
The core of the villus contains:
• Arteriole
• Capillary network
• Venule
• Lacteal - a vessel of the lymphatic system
Nutrients from chyme are absorbed into either the
capillary network or the lacteal
Water-soluble nutrients and certain fats are absorbed
into the capillary network
• Travel to the liver via the hepatic portal vein
Most lipids undergo specialized processing before they
enter the lacteals
© 2019 McGraw-Hill Education
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Transporting Absorbed
Nutrients to the Liver
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Assess Your Progress 4.5
16.List the three primary sections of the small
intestine, and indicate their functions.
17.Where is bile synthesized and stored?
18.Where does most nutrient digestion and
absorption occur?
19.Explain how the structure of villi increases
the surface area available for absorption.
20.Identify five ways that nutrients can enter
enterocytes.
© 2019 McGraw-Hill Education
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4.6 The Large Intestine
Learning Outcomes
1. Identify the sections of the large intestine.
2. Describe the role of the large intestine in nutrient
absorption and waste elimination.
© 2019 McGraw-Hill Education
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Parts of the Large Intestine
After moving through the ileocecal sphincter,
unabsorbed water and undigested remains of chyme
enter the:
• Cecum
• First segment of the
large intestine
• Ascending colon
• Transverse colon
• Descending colon
• Sigmoid colon
• Rectum
• Last segment of the
large intestine
• Anus
© 2019 McGraw-Hill Education
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Functions of the Large Intestine
Little absorption takes place in the large intestine
• Some water and minerals
Goblet-cells are intestinal cells that secrete mucus
• Primary secretion of the large intestine
As food residue passes through the colon, water is
absorbed, forming feces
The external anal sphincter allows feces to be expelled
from the anus and is under voluntary control
© 2019 McGraw-Hill Education
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Assess Your Progress 4.6
21.List the main sections of the large intestine
from the ileocecal sphincter to the anus.
22.What happens to chyme when it is in the
large intestine?
23.What is the typical composition of feces?
24.Trace the pathway of food from the mouth to
the anus, including key organs and their
functions.
© 2019 McGraw-Hill Education
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4.7 Microbes in the Digestive Tract
Learning Outcomes
1. Discuss the importance of bacteria in the digestive
tract.
2. Describe the role of prebiotics and probiotics in
human health and provide an example of each.
© 2019 McGraw-Hill Education
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Actions of Intestinal Bacteria
A healthy large intestine is home to vast
numbers of various bacteria (gut microbiota)
• Break down (ferment) undigested food
• Synthesize vitamins K, B‒12, thiamin, and biotin
• Produce substances that colon cells can use for
energy
• Metabolize certain phytochemicals (phenols) into
forms that can be absorbed and used by the body
© 2019 McGraw-Hill Education
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Probiotics and Prebiotics
Probiotics are live microorganisms that promote
good health for their human hosts
• Lactobacillus
• Bifidobacterium
Prebiotics are substances in food that are poorly
digested by humans but support and promote
the growth of probiotics in the colon
© 2019 McGraw-Hill Education
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Gut Microbiota Transplantation
Gut microbiota transplantation (GMT) –
commonly referred to as “fecal transplantation,”
the introduction of fecal material from one
person into another person’s colon
• Used to treat C-diff infection
• May benefit people with chronic intestinal disorders
• Ulcerative colitis
• Crohn’s disease
© 2019 McGraw-Hill Education
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Assess Your Progress 4.7
25.Summarize the roles intestinal bacteria play
in human health.
26.Explain the difference between a probiotic
and prebiotic, and give an example of each.
© 2019 McGraw-Hill Education
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4.8 Hormonal Regulation of Digestion
Learning Outcomes
1. Describe how gastrin, secretin, and cholecystokinin
(CCK) regulate digestion.
© 2019 McGraw-Hill Education
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The Hormones of Digestion
Three hormones play key roles in digestion:
• Gastrin - hormone secreted by G cells that stimulates
stomach motility and gastric gland secretions
• Secretin - hormone secreted by the duodenum and
first part of the jejunum that stimulates the pancreas
and liver to release a bicarbonate-rich solution into
the small intestine
• Cholecystokinin - hormone secreted by the mucosa
of the small intestine that stimulates the gallbladder
to contract and the pancreas to release pancreatic
juice into the small intestine
© 2019 McGraw-Hill Education
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Actions of Key Digestive Hormones
in the GI Tract
Hormone
Primarily
Released from Responds to Key Actions
Gastrin Stomach Food entering the
stomach
Triggers parietal cells to release HCl
and chief cells to release
pepsinogen
Stimulates stomach and small
intestinal motility
Secretin Small intestine Acidic chyme
entering the
duodenum and first
part of jejunum
Stimulates the release of a
bicarbonate-rich solution from the
liver and pancreas
Cholecysto-
kinin (CCK)
Small intestine Fat and breakdown
products of proteins
(peptides) entering
the small intestine
Stimulates release of bile from the
gallbladder into the small intestine
Stimulates the release of
pancreatic enzymes, decreases
stomach secretions, and slows
stomach motility
© 2019 McGraw-Hill Education
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Assess Your Progress 4.8
27.Identify the three major gut hormones,
including the tissues from which they are
released, the factors causing their release,
and their key actions.
© 2019 McGraw-Hill Education
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4.9 Common Digestive Tract Disorders
Learning Outcomes
1. Identify and describe common gastrointestinal
health problems.
2. Discuss preventative measures and treatments for
constipation, diarrhea, vomiting, heartburn, ulcers,
inflammatory bowel syndrome (IBS), and irritable
bowel disease (IBD).
© 2019 McGraw-Hill Education
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Constipation
Constipation - infrequent bowel movements and
feces that are difficult to eliminate
• Can be caused by
• Lack of dietary fiber
• Low water intake
• Anxiety
• Depression
• Changes in typical routine
• Ignoring the urge to have a bowel movement
© 2019 McGraw-Hill Education
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Hemorrhoids
Hemorrhoids - clusters of
small veins in the anal
canal
Chronic constipation and
straining during bowel
movements can play a
role in the development
of inflamed and swollen
hemorrhoids
© 2019 McGraw-Hill Education
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Diverticulosis and Diverticulitis
Diverticula - Small pouches that form in the wall
of the colon
• Diverticulosis - the condition characterized by the
presence of diverticula
• Diverticulitis - the condition characterized by
inflamed diverticula
• Bacteria or feces become trapped in the little pouches
• Blood vessels may become damaged and cause rectal
bleeding
© 2019 McGraw-Hill Education
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Diverticula
In this color-enhanced
x-ray, the blue areas
are diverticula
©Du Cane Medical Imaging Ltd/Science Source
© 2019 McGraw-Hill Education
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Diarrhea
Diarrhea is a condition characterized by
frequent, watery bowel movements
• More water secreted into GI tract
• Less water absorbed by GI tract
Most cases are caused by bacterial or viral
infections
© 2019 McGraw-Hill Education
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Vomiting
Vomiting is an effective
way of removing
harmful food or
beverages
Vomiting generally does
not last longer than 24
hours
Repeated vomiting can
lead to dehydration
Vomiting Danger Signs
1. Lasts longer than a few hours
(children under 6 years of age)
2. Lasts longer than a day (people
over 6 years of age)
3. Is accompanied by:
Blood in vomit (looks like coffee
grounds)
Signs of dehydration
Diarrhea
Fever
Weakness
Headache or stiff neck
Severe abdominal pain
Confusion or decreased
alertness
© 2019 McGraw-Hill Education
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Acid Reflux (Gastroesophageal Reflux)
Gastroesophageal reflux (GER) - commonly
called heartburn or acid reflux; the pain
generally felt in the upper chest that results from
the passage of acidic contents from the stomach
into the esophagus
Gastroesophageal reflux disease (GERD) - a
chronic condition characterized by frequent
heartburn that can damage the esophagus
© 2019 McGraw-Hill Education
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Acid Reflux Damage
An endoscopic view of
the esophagus near
the opening of the
stomach
The reddened areas
are signs of damage
caused by acid reflux
©David M. Martin, M.D./Science Source
© 2019 McGraw-Hill Education
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Factors That Contribute to or Worsen GER
Having excess body fat, especially around the
waistline
Drinking alcohol and coffee
Overeating
Eating chocolate, peppermint, and greasy or
spicy foods
Eating foods that contain tomatoes
Smoking or inhaling secondhand smoke
© 2019 McGraw-Hill Education
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Recommendations to Reduce the
Risk of Heartburn
1. Lose excess body weight.
2. Do not lie down within 3 hours after eating a meal.
3. Do not overeat at mealtimes.
4. Avoid smoking cigarettes or breathing secondhand
smoke.
5. Elevate the head of the bed so it is about 6 to 8
inches higher than the foot of the bed.
6. Do not wear tight belts or clothes with tight
waistbands.
7. Learn to recognize foods and beverages that cause
heartburn.
© 2019 McGraw-Hill Education
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Peptic Ulcer
A peptic ulcer is a sore
that occurs in the
lining of the stomach
or the upper small
intestine
• Symptoms include:
• Deep, dull upper
abdominal pain
• Feeling of fullness 2
hours after eating
Factors that increase
the risk of peptic ulcers:
• Infection with H. pylori
• NSAIDs
• Alcohol consumption
• Genetics
• Smoking
• Excess stomach acid
production
© 2019 McGraw-Hill Education
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Helicobacter pylori
Responsible for the
development of most
stomach ulcers
People infected with H.
pylori are given
antibiotics, as well as
medications that reduce
stomach acid production
©Science Photo Library RF/Getty Images RF
© 2019 McGraw-Hill Education
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Irritable Bowel Syndrome
Irritable bowel syndrome
(IBS) - a condition
characterized by intestinal
cramps and abnormal
bowel function
• Diarrhea, constipation, or
alternating episodes of
both
• Women are more likely to
suffer than men
• Cause is unknown
Foods and beverages often
eliminated in IBS diets:
• Fatty foods
• Some milk products
• Drinks that contain alcohol
or caffeine
• Drinks that contain large
amounts of artificial
sweeteners
• Beans, cabbage, cauliflower,
and other foods that
contribute to intestinal gas
© 2019 McGraw-Hill Education
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Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) - a condition
that is characterized by chronic inflammation of
the GI tract
• Crohn’s disease - a type of IBD; the body’s immune
system cells attack normal intestinal cells, damaging
parts of the intestines
• Ulcerative colitis (UC) - a type of IBD that causes
ulcers to form in the mucosa of the colon and
rectum
© 2019 McGraw-Hill Education
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Assess Your Progress 4.9
28. What are potential long-term consequences of frequent
untreated constipation?
29. Explain why vomiting for 24 hours and longer can be serious
enough to require medical attention.
30. Identify potential health effects of untreated, frequent GERD.
31. What factors contribute to the development of peptic ulcers?
32. What dietary recommendations would you provide to a
person experiencing irritable bowel syndrome (IBS)?
33. Describe the differences between Crohn’s disease and
ulcerative colitis.
© 2019 McGraw-Hill Education
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Case Study1
Annie is a 20-year-old college junior who is taking a full
course load. She is also actively involved in three
student organizations, and she volunteers over 10 hours
a week at the local hospital. Six months ago, Annie
experienced frequent bouts of diarrhea, followed by
several days of constipation.
At first, the diarrhea was mild, only once every few
weeks, but over the past few days, the diarrhea has
become daily, making it difficult for her to continue
attending classes and volunteering at the hospital.
© 2019 McGraw-Hill Education
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Case Study2
After examining Annie and taking her history, a
physician at the university’s Student Health Center tells
the young woman that she has irritable bowel
syndrome (IBS). The physician refers her to a registered
dietician who helps Annie understand how she can
prevent and manage the symptoms of IBS.
© 2019 McGraw-Hill Education
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Case Study3
1. What is IBS, and how does it differ from
inflammatory bowel disease (IBD)?
2. What are the long-term consequences to
untreated IBS?
3. Are there certain foods and/or beverages that
Annie should avoid?
4. What lifestyle changes should Annie consider
to manage IBS?
© 2019 McGraw-Hill Education
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Appendix of Image
Long Descriptions
© 2019 McGraw-Hill Education
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Components of the Digestive System - Appendix
The digestive system includes the salivary glands, teeth, tongue,
and pharynx in the mouth, and the esophagus, pancreas, liver,
stomach, gallbladder, small intestine, large intestine, rectum, and
anus.
Jump to the image
© 2019 McGraw-Hill Education
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Two GI Tract Sphincters - Appendix
This illustration shows the position of the lower esophageal and
the pyloric sphincters. (a). When the lower esophageal sphincter
relaxes, the mass of swallowed food enters the stomach (b). The
sphincter contracts to keep the mass from flowing back into the
esophagus (c).
Jump to the image
© 2019 McGraw-Hill Education
87
What Happens When You Swallow - Appendix
(a) While chewing, the epiglottis does not cover the larynx. (b)
When swallowing, the epiglottis prevents the bolus from entering
the larynx and trachea. (c) After swallowing, the epiglottis returns
to its usual position and allows air to enter the larynx and
trachea.
Jump to the image
© 2019 McGraw-Hill Education
88
First Aid for Choking - Appendix
A. Choking treatment for adults and children: 1. Stand behind the person and
wrap your arms around his or her waist. 2. Make a fist and place the thumb side
of your fist below the person’s ribcage and above the navel. 3. Hold your fist
with your other hand and press into his or her upper abdomen with a quick
upward thrust. Do not squeeze the ribcage. 4. Repeat thrusts until the object is
dislodged from the trachea and the person is breathing and able to talk. B.
Choking treatment for oneself: 1. Lean over a heavy, fixed structure such as a
chair, countertop, or railing. 2. Press your upper abdomen against the edge to
produce a quick upward thrust. 3. Repeat thrusts until the object that is blocking
the trachea is dislodged. OR, if no fixed large object is available: 1. Make a fist
and place the thumb side of your fist below the ribcage and above the navel. 2.
Hold your fist with your other hand and press into your upper abdomen with a
quick upward thrust. 3. Repeat thrusts until the object that is blocking the
trachea is dislodged. C. Choking treatment for infants: 1. Lay the child facedown
across your forearm. 2. Using the palm of your hand, give five forceful quick
blows on the infant’s back. 3. Repeat until the object is dislodged and the child is
breathing.
Jump to the image
© 2019 McGraw-Hill Education
89
Esophageal Sphincters - Appendix
(Top) When the lower esophageal sphincter relaxes, the mass of
swallowed food enters the stomach. (Bottom) The sphincter
contracts to keep the mass from flowing back into the
esophagus (c).
Jump to the image
© 2019 McGraw-Hill Education
90
pH Scale - Appendix
0: hydrochloric acid. 0.9 to 3.0: gastric juice. 2.0: chime as it
enters the duodenum. 2.3: lemon juice. 2.4 to 3.5: wine, vinegar,
cola, beer. 4.0: tomatoes. 5.0: black coffee. 6.3 to 6.6: milk,
urine, saliva. 7.0: pure water. 7.4: blood. 8.0: pancreatic juice,
bile, egg white, seawater. 9.5: household bleach, baking soda.
10.0: Great Salt Lake (Utah). 11.0: household ammonia. 13.4:
oven cleaner. 14: sodium hydroxide.
Jump to the image

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Stephenson 2ed_ch04_lecture_PPT.pptx

  • 1. HUMAN NUTRITION Science For Healthy Living Second Edition Tammy J. Stephenson, PhD University of Kentucky Wendy J. Schiff, MS, RDN © 2019 McGraw-Hill Education. All rights reserved. Authorized only for instructor use in the classroom. No reproduction or further distribution permitted without the prior written consent of McGraw-Hill Education.
  • 2. © 2019 McGraw-Hill Education 2 Chapter 4 Human Digestion, Absorption, and Transport Lecture Outline
  • 3. © 2019 McGraw-Hill Education 3 4.1 Overview of the Digestive System Learning Outcomes 1. Identify the major components of the digestive system and the major functions of each component. 2. Describe the distinct layers of the gastrointestinal tract wall. 3. Identify the location, anatomical name, and function of each sphincter involved in the digestive system. 4. Explain the differences between chemical and mechanical digestion.
  • 4. © 2019 McGraw-Hill Education 4 Roles of the Digestive System The primary roles of the digestive system are: • The breakdown of food into nutrients • Absorption of nutrients • Elimination of solid waste products Digestion is the process of breaking down large food molecules into nutrients that the body can use Absorption is the uptake and removal of nutrients from the digestive tract (gastrointestinal tract), alimentary canal, or gut
  • 5. © 2019 McGraw-Hill Education 5 Components of the Digestive System The digestive system has two major components: • GI tract • Hollow, muscular tube • Accessory organs • Assist functioning of GI tract Jump to long description
  • 6. © 2019 McGraw-Hill Education 6 The Wall of the GI Tract1 The wall of the GI tract has distinct layers: • Mucosa • Innermost layer of the digestive tract wall • Mucus, a watery slippery fluid, is secreted from special cells here • Surrounds the lumen, a hollow space through which food and fluids can pass • Muscular layer • Circular • Longitudinal
  • 7. © 2019 McGraw-Hill Education 7 The Wall of the GI Tract2 By relaxing and contracting, the muscles can: • Mix substances in the lumen • Control movement of material through the tract
  • 8. © 2019 McGraw-Hill Education 8 Muscle Layers of the Stomach The wall of the stomach is the thickest and strongest of the GI tract • Third type of muscle, diagonal muscle
  • 9. © 2019 McGraw-Hill Education 9 Sphincters Control the Flow of GI Contents Sphincters - thickened regions of circular muscle that control the flow of contents at various points in the GI tract • When contracted: • Passageway closed • Flow is restricted Essential for normal digestion and absorption
  • 10. © 2019 McGraw-Hill Education 10 Two GI Tract Sphincters Jump to long description
  • 11. © 2019 McGraw-Hill Education 11 Mechanical and Chemical Digestion Mechanical digestion - the physical treatments that food undergoes while it is in the intestinal tract Chemical digestion - the breakdown of large molecules in food into smaller components, primarily by the action of stomach acid and various enzymes, proteins that speed up the rate of a chemical reaction without being altered in the process
  • 12. © 2019 McGraw-Hill Education 12 Assess Your Progress 4.1 1. List the primary and accessory components of the GI tract. 2. What is a sphincter? 3. Explain the difference between mechanical and chemical digestion. 4. What is a hydrolytic enzyme?
  • 13. © 2019 McGraw-Hill Education 13 4.2 The Mouth Learning Outcomes 1. Describe the mechanical and chemical digestion that occurs in the mouth. 2. Identify and explain the effects of smell and taste disorders in humans.
  • 14. © 2019 McGraw-Hill Education 14 Digestion Starts in the Mouth Oral cavity is another term for mouth • Digestion starts here Teeth masticate food • Prepares food for swallowing and chemical digestion Tongue helps direct food into the pharynx, the section of alimentary canal that connects the nasal cavity with the top of the esophagus
  • 15. © 2019 McGraw-Hill Education 15 Salivary Glands1 Salivary glands - structures that produce saliva and secrete the fluid in the oral cavity Saliva - the watery fluid that contains mucus and a few enzymes • Lysozyme - enzyme in saliva that can destroy some bacteria that are in food or the mouth • Salivary amylase - enzyme in saliva that begins starch digestion • Lingual Lipase - enzyme secreted in saliva that begins fat digestion
  • 16. © 2019 McGraw-Hill Education 16 Salivary Glands2
  • 17. © 2019 McGraw-Hill Education 17 Taste Buds Taste buds have specialized cells that help distinguish five basic tastes: • Sweet • Sour • Salty • Bitter • Umami
  • 18. © 2019 McGraw-Hill Education 18 Sense of Smell The sense of smell (olfaction) contributes to the ability to taste food Airborne chemicals in chewed food stimulate the olfactory region of the nasal passages
  • 19. © 2019 McGraw-Hill Education 19 Disorders of Taste and Smell Anosmia - the complete inability to detect odors Hypogeusia - the diminished ability to taste substances Ageusia - the total loss of the ability to taste substances
  • 20. © 2019 McGraw-Hill Education 20 Assess Your Progress 4.2 5. Explain what normally happens to a piece of food that enters the mouth. 6. Identify the key components of saliva. 7. List the taste sensations that human taste buds detect. 8. Discuss disorders of taste and smell, including their causes.
  • 21. © 2019 McGraw-Hill Education 21 4.3 The Esophagus Learning Outcomes 1. Describe the action of swallowing and what it accomplishes. 2. Identify the muscular activity that propels a mass of food through the esophagus. 3. Explain what happens when someone is choking on food and demonstrate the first aid techniques employed to save the person’s life. 4. Identify the two esophageal sphincters and their functions.
  • 22. © 2019 McGraw-Hill Education 22 The Esophagus After being swallowed, the food bolus travels through the esophagus • Muscular tube that extends about 10 inches from the pharynx to the upper portion of the stomach • Entrance is near the larynx and opening of trachea
  • 23. © 2019 McGraw-Hill Education 23 What Happens When You Swallow The epiglottis is a flap of tough tissue that prevents the food from entering the larynx and trachea Jump to long description
  • 24. © 2019 McGraw-Hill Education 24 First Aid for Choking Jump to long description
  • 25. © 2019 McGraw-Hill Education 25 Peristalsis Peristalsis - waves of muscular contractions that help move material through most of the digestive tract • Involuntary response
  • 26. © 2019 McGraw-Hill Education 26 Esophageal Sphincters Upper esophageal sphincter (UES) - the region of the upper part of the esophagus that opens to allow a mass of food to enter the esophagus Lower esophageal sphincter (LES) - the region of the lower part of the esophagus that controls flow of material into the upper part of the stomach • Gastroesophageal sphincter • Prevents backflow of stomach contents Jump to long description
  • 27. © 2019 McGraw-Hill Education 27 Assess Your Progress 4.3 9. Describe peristalsis. Explain how peristalsis in the esophagus transfers a bolus of food from the throat to the stomach. 10.Explain why choking can occur while eating. What should you do to save a choking person’s life? 11.What normally keeps stomach contents from reentering the esophagus?
  • 28. © 2019 McGraw-Hill Education 28 4.4 The Stomach Learning Outcomes 1. Identify the types of cells in the gastric glands and what each secretes. 2. Describe the kinds of mechanical and chemical digestion that occur in the stomach. 3. List the components of gastric juice. 4. Discuss factors that influence stomach emptying.
  • 29. © 2019 McGraw-Hill Education 29 Secretions of the Stomach1 The stomach is a muscular sac that stores and mixes food Gastric glands located in the stomach synthesize and secrete gastric juice • A collection of stomach secretions that includes mucus, hydrochloric acid, intrinsic factor, and digestive enzymes Mucous cells secret mucin, a carbohydrate-rich substance that forms mucus when combined with water
  • 30. © 2019 McGraw-Hill Education 30 Secretions of the Stomach2 Parietal cells secrete hydrogen and chloride ions, which form hydrochloric acid (HCl) and intrinsic factor • Intrinsic factor is a substance necessary for absorbing vitamin B‒12 Chief cells secrete gastric lipase and some chemically inactive digestive enzymes like pepsinogen G cells secrete gastrin, a hormone that stimulates stomach motility and gastric gland secretions • Hormones are chemical messengers that convey information to target cells
  • 31. © 2019 McGraw-Hill Education 31 Gastric Gland and Its Secretory Cells
  • 32. © 2019 McGraw-Hill Education 32 Gastric Gland Cells Gastric Gland Cells Secretion Major Functions Mucous Mucus Protects stomach mucosa from HCl and enzymes Parietal Components that form HCl (hydrogen ions [H+] and chloride ions [Cl-]) Intrinsic factor Activates pepsinogen, destroys many food-borne microbes Facilitates the absorption of vitamin B-12 Chief Pepsinogen Gastric lipase Digests protein after conversion to pepsin Digests small amount of fat G cell Gastrin Stimulates stomach motility and gastric gland activity
  • 33. © 2019 McGraw-Hill Education 33 Lower Portion of the Stomach The main function of the lower portion of the stomach is mixing food with gastric juice to form chyme, a semiliquid mass The pyloric sphincter regulates the flow of chyme into the small intestine
  • 34. © 2019 McGraw-Hill Education 34 Digestion in the Stomach The presence of food in the stomach stimulates peristalsis • Mixes food with gastric juices • Some protein and fat is broken down Few substances are absorbed in the stomach HCl contributes to low pH of gastric juice • Acidic solutions have a pH value lower than 7 • pH of chyme is 2.0 • Alkaline solutions have a pH value higher than 7
  • 35. © 2019 McGraw-Hill Education 35 pH Scale Lemon and Wine: ©Brand X Pictures/Getty Images RF; Cola: ©FoodCollection/StockFood RF; Tomato and Banana: ©Stockbyte/Getty Images RF; Coffee: ©Fuse/Getty Images RF; Milk: ©McGraw-Hill Education. Bob Coyle, photographer; Egg: ©Siede Preis/Getty Images RF; Household items: ©McGraw-Hill Education. Stephen Frisch, photographer; Ammonia: ©McGraw-Hill Education. Jacques Cornell, photographer; Oven cleaner: ©McGraw-Hill Education. Ken Karp, photographer Jump to long description
  • 36. © 2019 McGraw-Hill Education 36 Acid in the Stomach Acidic environment of stomach causes: • Salivary amylase to cease • Lingual lipase to become active • Pepsinogen to be converted to pepsin, which begins the enzymatic digestion of protein Mucus is a slippery secretion that protects the stomach from being damaged by its acid and digestive enzymes • Produced by mucous cells • If the layer of mucus breaks down, HCl and gastric enzymes contact the stomach wall and gastric or peptic ulcers can form
  • 37. © 2019 McGraw-Hill Education 37 Stomach Emptying Stomach empties in about 4 hours following a meal • Varies with contents and size of meal Dumping syndrome - a disorder that occurs when chyme flows too rapidly into the small intestine • Often occurs after surgeries of the esophagus or stomach • Changing the types of food eaten (fewer sugary foods), eating smaller meals, and taking certain medications may help
  • 38. © 2019 McGraw-Hill Education 38 Assess Your Progress 4.4 12.Identify the four different gastric gland cells and the secretions they produce. 13.Describe the digestive processes that occur in the stomach. 14.Explain how the stomach protects itself from digestion. What conditions might occur if this protection fails? 15.List factors that influence stomach emptying.
  • 39. © 2019 McGraw-Hill Education 39 4.5 The Small Intestine Learning Outcomes 1. Identify the three primary digestive sections of the small intestine. 2. Describe the functions of the digestive system’s accessory organs. 3. Discuss the functions of intestinal villi. 4. Compare and contrast the ways nutrients may be absorbed.
  • 40. © 2019 McGraw-Hill Education 40 Parts of the Small Intestine1 The small intestine has three sections: • Duodenum - first segment of the small intestine • Jejunum - middle segment of the small intestine • Ileum - last segment of the small intestine Chyme moves out of the ileum into the large intestine, passing through the ileocecal sphincter, which controls the rate that ileum contents empty into the large intestine
  • 41. © 2019 McGraw-Hill Education 41 Parts of the Small Intestine2
  • 42. © 2019 McGraw-Hill Education 42 Accessory Organs1 The liver, gallbladder, and pancreas are accessory organs of the gastrointestinal system • Chyme does not pass through them • Play a major role in digestion
  • 43. © 2019 McGraw-Hill Education 43 Accessory Organs2 The liver: • Processes and stores many nutrients • Synthesizes cholesterol • Makes bile, a greenish-yellow, bitter-tasting fluid stored in the gallbladder until it is needed for fat digestion and absorption The gallbladder stores and concentrates bile The pancreas produces and secretes digestive enzymes and bicarbonate ions to neutralize acidic chyme when it enters the duodenum
  • 44. © 2019 McGraw-Hill Education 44 Digestion in the Small Intestine The small intestine is the major site of chemical and mechanical digestion • Enzyme activity • Peristalsis • Segmentation - regular contractions of circular intestinal muscles followed by relaxations that mix chyme within a short portion of the small intestine
  • 45. © 2019 McGraw-Hill Education 45 Major Pancreatic and Intestinal Enzymes Enzyme Source Action Pancreatic amylase Pancreas Digests starch Pancreatic lipase Pancreas Digests fat Trypsin, chymotrypsin Pancreas Partially digest proteins Carboxypeptidase Pancreas Breaks down certain partially digested proteins Nuclease Pancreas Digests DNA and RNA into nucleotides Peptidase Small intestine Breaks down certain partially digested proteins Sucrase, maltase, lactase Small intestine Break down certain sugars into simpler sugars Intestinal lipase Small intestine Digests fat
  • 46. © 2019 McGraw-Hill Education 46 Villi and Surface Area Villi - tiny, fingerlike projections of the small intestinal mucosa that are involved in digestion and nutrient absorption • Cover the folds of the mucosa of the small intestine • Enterocytes - absorptive cells that form the outer layer of a villus The end of the enterocyte exposed to chyme contains microvilli, tiny, hairlike projections that form the brush border of an enterocyte • Contain brush border enzymes that help digest protein and carbohydrates
  • 47. © 2019 McGraw-Hill Education 47 Small Intestinal Absorption Villi are absorptive structures Enterocytes remove nutrients from chyme and enable them to enter the intestinal blood or lymph vessels
  • 48. © 2019 McGraw-Hill Education 48 Nutrient Absorption Nutrient absorption can occur by: • Simple diffusion • Facilitated diffusion • Active transport • Osmosis • Endocytosis
  • 49. © 2019 McGraw-Hill Education 49 Core of the Villus The core of the villus contains: • Arteriole • Capillary network • Venule • Lacteal - a vessel of the lymphatic system Nutrients from chyme are absorbed into either the capillary network or the lacteal Water-soluble nutrients and certain fats are absorbed into the capillary network • Travel to the liver via the hepatic portal vein Most lipids undergo specialized processing before they enter the lacteals
  • 50. © 2019 McGraw-Hill Education 50 Transporting Absorbed Nutrients to the Liver
  • 51. © 2019 McGraw-Hill Education 51 Assess Your Progress 4.5 16.List the three primary sections of the small intestine, and indicate their functions. 17.Where is bile synthesized and stored? 18.Where does most nutrient digestion and absorption occur? 19.Explain how the structure of villi increases the surface area available for absorption. 20.Identify five ways that nutrients can enter enterocytes.
  • 52. © 2019 McGraw-Hill Education 52 4.6 The Large Intestine Learning Outcomes 1. Identify the sections of the large intestine. 2. Describe the role of the large intestine in nutrient absorption and waste elimination.
  • 53. © 2019 McGraw-Hill Education 53 Parts of the Large Intestine After moving through the ileocecal sphincter, unabsorbed water and undigested remains of chyme enter the: • Cecum • First segment of the large intestine • Ascending colon • Transverse colon • Descending colon • Sigmoid colon • Rectum • Last segment of the large intestine • Anus
  • 54. © 2019 McGraw-Hill Education 54 Functions of the Large Intestine Little absorption takes place in the large intestine • Some water and minerals Goblet-cells are intestinal cells that secrete mucus • Primary secretion of the large intestine As food residue passes through the colon, water is absorbed, forming feces The external anal sphincter allows feces to be expelled from the anus and is under voluntary control
  • 55. © 2019 McGraw-Hill Education 55 Assess Your Progress 4.6 21.List the main sections of the large intestine from the ileocecal sphincter to the anus. 22.What happens to chyme when it is in the large intestine? 23.What is the typical composition of feces? 24.Trace the pathway of food from the mouth to the anus, including key organs and their functions.
  • 56. © 2019 McGraw-Hill Education 56 4.7 Microbes in the Digestive Tract Learning Outcomes 1. Discuss the importance of bacteria in the digestive tract. 2. Describe the role of prebiotics and probiotics in human health and provide an example of each.
  • 57. © 2019 McGraw-Hill Education 57 Actions of Intestinal Bacteria A healthy large intestine is home to vast numbers of various bacteria (gut microbiota) • Break down (ferment) undigested food • Synthesize vitamins K, B‒12, thiamin, and biotin • Produce substances that colon cells can use for energy • Metabolize certain phytochemicals (phenols) into forms that can be absorbed and used by the body
  • 58. © 2019 McGraw-Hill Education 58 Probiotics and Prebiotics Probiotics are live microorganisms that promote good health for their human hosts • Lactobacillus • Bifidobacterium Prebiotics are substances in food that are poorly digested by humans but support and promote the growth of probiotics in the colon
  • 59. © 2019 McGraw-Hill Education 59 Gut Microbiota Transplantation Gut microbiota transplantation (GMT) – commonly referred to as “fecal transplantation,” the introduction of fecal material from one person into another person’s colon • Used to treat C-diff infection • May benefit people with chronic intestinal disorders • Ulcerative colitis • Crohn’s disease
  • 60. © 2019 McGraw-Hill Education 60 Assess Your Progress 4.7 25.Summarize the roles intestinal bacteria play in human health. 26.Explain the difference between a probiotic and prebiotic, and give an example of each.
  • 61. © 2019 McGraw-Hill Education 61 4.8 Hormonal Regulation of Digestion Learning Outcomes 1. Describe how gastrin, secretin, and cholecystokinin (CCK) regulate digestion.
  • 62. © 2019 McGraw-Hill Education 62 The Hormones of Digestion Three hormones play key roles in digestion: • Gastrin - hormone secreted by G cells that stimulates stomach motility and gastric gland secretions • Secretin - hormone secreted by the duodenum and first part of the jejunum that stimulates the pancreas and liver to release a bicarbonate-rich solution into the small intestine • Cholecystokinin - hormone secreted by the mucosa of the small intestine that stimulates the gallbladder to contract and the pancreas to release pancreatic juice into the small intestine
  • 63. © 2019 McGraw-Hill Education 63 Actions of Key Digestive Hormones in the GI Tract Hormone Primarily Released from Responds to Key Actions Gastrin Stomach Food entering the stomach Triggers parietal cells to release HCl and chief cells to release pepsinogen Stimulates stomach and small intestinal motility Secretin Small intestine Acidic chyme entering the duodenum and first part of jejunum Stimulates the release of a bicarbonate-rich solution from the liver and pancreas Cholecysto- kinin (CCK) Small intestine Fat and breakdown products of proteins (peptides) entering the small intestine Stimulates release of bile from the gallbladder into the small intestine Stimulates the release of pancreatic enzymes, decreases stomach secretions, and slows stomach motility
  • 64. © 2019 McGraw-Hill Education 64 Assess Your Progress 4.8 27.Identify the three major gut hormones, including the tissues from which they are released, the factors causing their release, and their key actions.
  • 65. © 2019 McGraw-Hill Education 65 4.9 Common Digestive Tract Disorders Learning Outcomes 1. Identify and describe common gastrointestinal health problems. 2. Discuss preventative measures and treatments for constipation, diarrhea, vomiting, heartburn, ulcers, inflammatory bowel syndrome (IBS), and irritable bowel disease (IBD).
  • 66. © 2019 McGraw-Hill Education 66 Constipation Constipation - infrequent bowel movements and feces that are difficult to eliminate • Can be caused by • Lack of dietary fiber • Low water intake • Anxiety • Depression • Changes in typical routine • Ignoring the urge to have a bowel movement
  • 67. © 2019 McGraw-Hill Education 67 Hemorrhoids Hemorrhoids - clusters of small veins in the anal canal Chronic constipation and straining during bowel movements can play a role in the development of inflamed and swollen hemorrhoids
  • 68. © 2019 McGraw-Hill Education 68 Diverticulosis and Diverticulitis Diverticula - Small pouches that form in the wall of the colon • Diverticulosis - the condition characterized by the presence of diverticula • Diverticulitis - the condition characterized by inflamed diverticula • Bacteria or feces become trapped in the little pouches • Blood vessels may become damaged and cause rectal bleeding
  • 69. © 2019 McGraw-Hill Education 69 Diverticula In this color-enhanced x-ray, the blue areas are diverticula ©Du Cane Medical Imaging Ltd/Science Source
  • 70. © 2019 McGraw-Hill Education 70 Diarrhea Diarrhea is a condition characterized by frequent, watery bowel movements • More water secreted into GI tract • Less water absorbed by GI tract Most cases are caused by bacterial or viral infections
  • 71. © 2019 McGraw-Hill Education 71 Vomiting Vomiting is an effective way of removing harmful food or beverages Vomiting generally does not last longer than 24 hours Repeated vomiting can lead to dehydration Vomiting Danger Signs 1. Lasts longer than a few hours (children under 6 years of age) 2. Lasts longer than a day (people over 6 years of age) 3. Is accompanied by: Blood in vomit (looks like coffee grounds) Signs of dehydration Diarrhea Fever Weakness Headache or stiff neck Severe abdominal pain Confusion or decreased alertness
  • 72. © 2019 McGraw-Hill Education 72 Acid Reflux (Gastroesophageal Reflux) Gastroesophageal reflux (GER) - commonly called heartburn or acid reflux; the pain generally felt in the upper chest that results from the passage of acidic contents from the stomach into the esophagus Gastroesophageal reflux disease (GERD) - a chronic condition characterized by frequent heartburn that can damage the esophagus
  • 73. © 2019 McGraw-Hill Education 73 Acid Reflux Damage An endoscopic view of the esophagus near the opening of the stomach The reddened areas are signs of damage caused by acid reflux ©David M. Martin, M.D./Science Source
  • 74. © 2019 McGraw-Hill Education 74 Factors That Contribute to or Worsen GER Having excess body fat, especially around the waistline Drinking alcohol and coffee Overeating Eating chocolate, peppermint, and greasy or spicy foods Eating foods that contain tomatoes Smoking or inhaling secondhand smoke
  • 75. © 2019 McGraw-Hill Education 75 Recommendations to Reduce the Risk of Heartburn 1. Lose excess body weight. 2. Do not lie down within 3 hours after eating a meal. 3. Do not overeat at mealtimes. 4. Avoid smoking cigarettes or breathing secondhand smoke. 5. Elevate the head of the bed so it is about 6 to 8 inches higher than the foot of the bed. 6. Do not wear tight belts or clothes with tight waistbands. 7. Learn to recognize foods and beverages that cause heartburn.
  • 76. © 2019 McGraw-Hill Education 76 Peptic Ulcer A peptic ulcer is a sore that occurs in the lining of the stomach or the upper small intestine • Symptoms include: • Deep, dull upper abdominal pain • Feeling of fullness 2 hours after eating Factors that increase the risk of peptic ulcers: • Infection with H. pylori • NSAIDs • Alcohol consumption • Genetics • Smoking • Excess stomach acid production
  • 77. © 2019 McGraw-Hill Education 77 Helicobacter pylori Responsible for the development of most stomach ulcers People infected with H. pylori are given antibiotics, as well as medications that reduce stomach acid production ©Science Photo Library RF/Getty Images RF
  • 78. © 2019 McGraw-Hill Education 78 Irritable Bowel Syndrome Irritable bowel syndrome (IBS) - a condition characterized by intestinal cramps and abnormal bowel function • Diarrhea, constipation, or alternating episodes of both • Women are more likely to suffer than men • Cause is unknown Foods and beverages often eliminated in IBS diets: • Fatty foods • Some milk products • Drinks that contain alcohol or caffeine • Drinks that contain large amounts of artificial sweeteners • Beans, cabbage, cauliflower, and other foods that contribute to intestinal gas
  • 79. © 2019 McGraw-Hill Education 79 Inflammatory Bowel Disease Inflammatory bowel disease (IBD) - a condition that is characterized by chronic inflammation of the GI tract • Crohn’s disease - a type of IBD; the body’s immune system cells attack normal intestinal cells, damaging parts of the intestines • Ulcerative colitis (UC) - a type of IBD that causes ulcers to form in the mucosa of the colon and rectum
  • 80. © 2019 McGraw-Hill Education 80 Assess Your Progress 4.9 28. What are potential long-term consequences of frequent untreated constipation? 29. Explain why vomiting for 24 hours and longer can be serious enough to require medical attention. 30. Identify potential health effects of untreated, frequent GERD. 31. What factors contribute to the development of peptic ulcers? 32. What dietary recommendations would you provide to a person experiencing irritable bowel syndrome (IBS)? 33. Describe the differences between Crohn’s disease and ulcerative colitis.
  • 81. © 2019 McGraw-Hill Education 81 Case Study1 Annie is a 20-year-old college junior who is taking a full course load. She is also actively involved in three student organizations, and she volunteers over 10 hours a week at the local hospital. Six months ago, Annie experienced frequent bouts of diarrhea, followed by several days of constipation. At first, the diarrhea was mild, only once every few weeks, but over the past few days, the diarrhea has become daily, making it difficult for her to continue attending classes and volunteering at the hospital.
  • 82. © 2019 McGraw-Hill Education 82 Case Study2 After examining Annie and taking her history, a physician at the university’s Student Health Center tells the young woman that she has irritable bowel syndrome (IBS). The physician refers her to a registered dietician who helps Annie understand how she can prevent and manage the symptoms of IBS.
  • 83. © 2019 McGraw-Hill Education 83 Case Study3 1. What is IBS, and how does it differ from inflammatory bowel disease (IBD)? 2. What are the long-term consequences to untreated IBS? 3. Are there certain foods and/or beverages that Annie should avoid? 4. What lifestyle changes should Annie consider to manage IBS?
  • 84. © 2019 McGraw-Hill Education 84 Appendix of Image Long Descriptions
  • 85. © 2019 McGraw-Hill Education 85 Components of the Digestive System - Appendix The digestive system includes the salivary glands, teeth, tongue, and pharynx in the mouth, and the esophagus, pancreas, liver, stomach, gallbladder, small intestine, large intestine, rectum, and anus. Jump to the image
  • 86. © 2019 McGraw-Hill Education 86 Two GI Tract Sphincters - Appendix This illustration shows the position of the lower esophageal and the pyloric sphincters. (a). When the lower esophageal sphincter relaxes, the mass of swallowed food enters the stomach (b). The sphincter contracts to keep the mass from flowing back into the esophagus (c). Jump to the image
  • 87. © 2019 McGraw-Hill Education 87 What Happens When You Swallow - Appendix (a) While chewing, the epiglottis does not cover the larynx. (b) When swallowing, the epiglottis prevents the bolus from entering the larynx and trachea. (c) After swallowing, the epiglottis returns to its usual position and allows air to enter the larynx and trachea. Jump to the image
  • 88. © 2019 McGraw-Hill Education 88 First Aid for Choking - Appendix A. Choking treatment for adults and children: 1. Stand behind the person and wrap your arms around his or her waist. 2. Make a fist and place the thumb side of your fist below the person’s ribcage and above the navel. 3. Hold your fist with your other hand and press into his or her upper abdomen with a quick upward thrust. Do not squeeze the ribcage. 4. Repeat thrusts until the object is dislodged from the trachea and the person is breathing and able to talk. B. Choking treatment for oneself: 1. Lean over a heavy, fixed structure such as a chair, countertop, or railing. 2. Press your upper abdomen against the edge to produce a quick upward thrust. 3. Repeat thrusts until the object that is blocking the trachea is dislodged. OR, if no fixed large object is available: 1. Make a fist and place the thumb side of your fist below the ribcage and above the navel. 2. Hold your fist with your other hand and press into your upper abdomen with a quick upward thrust. 3. Repeat thrusts until the object that is blocking the trachea is dislodged. C. Choking treatment for infants: 1. Lay the child facedown across your forearm. 2. Using the palm of your hand, give five forceful quick blows on the infant’s back. 3. Repeat until the object is dislodged and the child is breathing. Jump to the image
  • 89. © 2019 McGraw-Hill Education 89 Esophageal Sphincters - Appendix (Top) When the lower esophageal sphincter relaxes, the mass of swallowed food enters the stomach. (Bottom) The sphincter contracts to keep the mass from flowing back into the esophagus (c). Jump to the image
  • 90. © 2019 McGraw-Hill Education 90 pH Scale - Appendix 0: hydrochloric acid. 0.9 to 3.0: gastric juice. 2.0: chime as it enters the duodenum. 2.3: lemon juice. 2.4 to 3.5: wine, vinegar, cola, beer. 4.0: tomatoes. 5.0: black coffee. 6.3 to 6.6: milk, urine, saliva. 7.0: pure water. 7.4: blood. 8.0: pancreatic juice, bile, egg white, seawater. 9.5: household bleach, baking soda. 10.0: Great Salt Lake (Utah). 11.0: household ammonia. 13.4: oven cleaner. 14: sodium hydroxide. Jump to the image