Cough is a protective reflex caused by stimulation of sensory nerves in the respiratory tract mucosa. It serves to expel respiratory secretions induced by infections or irritants like smoke. There are three main types of drugs used to treat cough - expectorants to increase mucus secretion and thinning, mucolytics to break up thick mucus, and antitussives/cough suppressants to reduce cough reflex. Antihistamines work by blocking the H1 receptor and antagonizing the effects of the chemical histamine, which is involved in allergic responses. First and second generation antihistamines are used to treat allergic diseases by reducing symptoms like itching, as well as other conditions involving histamine release such as