Hypolipidemics

1. Hypolipidemic DrugsHypolipidemic Drugs

2. Statins:Statins:
Simvastatin, Atorvastatin,Simvastatin, Atorvastatin,
Bile Acid BindingBile Acid Binding Resins:Resins:
Cholestyramine, Colestipol,Cholestyramine, Colestipol,
Nicotinic acidNicotinic acid
NiacinNiacin
Fibric Acid DerivativesFibric Acid Derivatives
GemfibrozilGemfibrozil and Fenofibrateand Fenofibrate
EzetimibeEzetimibe

3. Statins
HMG-CoA Reductase InhibitorsHMG-CoA Reductase Inhibitors
HMG-CoAHMG-CoA  CholesterolCholesterol  bilebile
acidsacids
___
HMG-CoA Reductase
Statins

4. StatinsStatins
Side Effects:
Elevations of serum aminotransferase
level ( liver enzymes)
Myositis (muscle pain), rhabdomyolysis,
myoglobinemia, acute renal failure
Headache, nausea, bowel upset

5. Uses of statinsUses of statins
Familial hypercholestrolemiaFamilial hypercholestrolemia
Familial combined hyperlipidemiaFamilial combined hyperlipidemia

6. EZETIMIBEEZETIMIBE
Decreases GI Uptake of cholesterol
Synergistic action with statin
Statin decreased synthesis of
cholesterol in liver
+
Ezetimibe  absorption from intestine

7. NiacinNiacin
Side EffectsSide Effects
FlushingFlushing, tachycardia, dry skin,, tachycardia, dry skin,
nausea,nausea,

8. Fibric Acid DerivativesFibric Acid Derivatives
Gemfibrozil and FenofibrateGemfibrozil and Fenofibrate
Lower triglycerides and raise HDLLower triglycerides and raise HDL

9. Fibric Acid DerivativesFibric Acid Derivatives
Side EffectsSide Effects
Rash, GI symptoms,Rash, GI symptoms, myopathy,myopathy, highhigh
aminotransferaseaminotransferase

10. Sites of Action for HypolipidemicsSites of Action for Hypolipidemics