Fibrinolytics

1. FIBRINOLYTIC &
ANTIFIBRINOLYTIC DRUGS

2. FIBRINOLYTICS (THROMBOLYTICS)
Drugs used to dissolve (lyse) blood clots
(thrombi)
Examples:
• Streptokinase, urokinase, alteplase, reteplase

3. Uses
• Acute myocardial infarction - to recanalyze
thrombosed coronary artery
• Deep vein thrombosis: Thrombolytic therapy
helps to prevent pulmonary embolism.
• Pulmonary embolism: Fibrinolytics are used
to lyse the clot.

4. ANTIFIBRINOLYTICS
Antifibrinolytics inhibit fibrinolytic activity
Examples:
1. Epsilon amino–caproic acid (EACA)
• Used to control bleeding due to overdose of
fibrinolytics
• After tooth extraction and prostatic surgery
• In menorrhagia, hematuria and bleeding due
to surgery or obstetric complications

5. 2. Tranexaemic acid
• Used to control bleeding due to excessive
fibrinolytic activity
• Also in tonsillectomy, prostatectomy, tooth
extraction, menorrhagia etc.