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APPROACH TO
HEMOPTYSIS
Professor (Dr.)N.K.Sit.
MBBS.DCH.MD(chest)
Professor &Head
Dept of Respiratory Medicine
Rampurhat Govt. Medical College.
DEFINITION
• Hemoptysis is the expectoration of blood and it can
range from blood-streaking of sputum to the
presence of gross blood in the absence of any
accompanying sputum.
• The term massive hemoptysis is reserved for
bleeding that is potentially life-threatening.
• It has been defined by a number of different criteria,
often ranging from more than 100 to more than 600
ml of blood over a 24 hour period.
CAUSES OF HEMOPTYSIS
1. INFLAMMATORY
Pulmonary Tuberculosis
Chronic bronchitis
Bronchiectasis
Lung abscess
Pneumonia( klebsiella)
Parasitic (Paragonimiasis)
Fungal (Mycetoma)
2.NEOPLASTIC
Bronchogenic carcinoma.
Bronchial adenoma.
Endobronchial metastasis.
Carcinoid tumor
3.CARDIOVASCULAR
Mitral stenosis
Pulmonary Thromboembolism
LVF
Primary Pulmonary Hypertension
Eisenmengers syndrome.
Arteriovenous malformation.
4.TRAUMATIC
Foreign body.
Lung contusion.
Blunt/Penetrating chest injury.
Bronchial disruption.
Bronchoscopies.
Lung Biopsies.
5.PULMONARY VASCULITIS
Wegners granulomatosis
Goodpasture’s syndrome
Systemic lupus erythematosus
6.Miscellaneous
Pulmonary amyloidosis
Idiopathic pulmonary haemosiderosis
Broncholiths
Bleeding diathesis
Munchausen syndrome
Catamenial haemoptysis.
Congenital ( bronchial cyst, sequestration)
6) Drugs
Anticoagulents
Cocaine
Penicillamine
Amiodarone
CAUSES OF HEMOPTYSIS
DIFFERENTIATING FEATURE OF HAEMOPTYSIS
AND HAEMATEMESIS
• HAEMOPTYSIS HAEMATEMESIS
• HISTORY
• Absence of nausea and Presence of nausea and vomiting
vomiting.
Lung disease. Gastric or hepatic disease
Asphyxia possible. Asphyxia unusual.
SPUTUM EXAMINATION
Frothy, Liquid or clotted Rarely frothy, coffy
appearance, Bright red or pink ground in appearance
In colour brown to black in
colour
• INVESTIGATION
Alkaline ph Acidic ph
Mixed with macrophage Mixed with food
And neutrophil. Particle.
HISTORY
1) Age:
• Children – foreign body, bronchiectasis,
pulmonary tuberculosis, pneumonia
• Adults – tuberculosis, bronchiectasis,
• Old age – bronchogenic carcinoma
2) Risk factors:
• Smoking
• Asbestos exposure
• Contact with TB pt
Bronchogenic Ca
3) Associated symptoms:
• Blood-streaking of mucopurulent or purulent
sputum  bronchitis
• If accompanied by fever or chills – pneumonia
• Putrid smell to sputum – lung abscess
• Chronic and copious sputum production-
bronchiectasis
• Assoc. acute onset of pleuritic chest pain and
dyspnoea – pulmonary embolism
• Dyspnoea and other cardiac symptoms –
mitral stenosis
4) Previous /co-existing disorders:
• Renal disease ( Goodpasture’s syndrome,
Wegener’s granulomatosis)
• Lupus erythematosus( with asso. Pulmonary
h’age from lupus pneumonitis)
• Malignancy (recurrent lung Ca or
endobronchial metastasis from non-pulmonary
tumour)
• Bleeding disorders- bleeding from other sites
• AIDS pts- endobronchial or pulmonary
parenchymal Kaposi’s sarcoma
5) Treatment History:
• Any malignancy
• Recent chemotherapy
• Bone marrow transplant
• Anticoagulants
6) H/o Trauma:
• Gun-shot wounds
• Fracture of ribs
PHYSICAL EXAMINATION
1) Respiratory system:
Pleural friction rub – pulmonary embolism
Localised or diffuse crepitations : parenchymal
bleeding
Evidence of airflow obstruction: chr. Bronchitis
2) Cardiovascular system:
• Findings of pulmonary artery HTN , mitral
stenosis ( OS, mid-diastolic murmur)
3) Skin and mucosa:
• Kaposi’s sarcoma
• SLE lesions
• Splinter hemorrhages- endocarditis or
vasculitis
INVESTIGATIONS
1) Complete Blood Count- Hb, TC, DLC,ESR, platelet
count, bld gp
2) Coagulation profile
3) Urine analysis – red cells and red cell casts
4) Blood urea nitrogen and creatinine levels
5) Sputum :
• Z-N staining – acid fast bacilli ( PTB)
• Gram staining
• Cytological examination- malignant cells
• Culture – isolation of organisms
6) Chest X-Ray : ( PA and lateral)
• Cystic lesions, tram tracks, ring shadows -
bronchiectasis
• Distinct air- fluid level: lung abscess
 Mass lesion
 Focal or diffuse parenchymal disease- pneumonia
 Tubercular fluffy opacity.
7) CT scan:
• Carcinoma
• Bronchiectasis- diagnostic procedure of choice
• Lung abscess
8) ECHO:
• MS, pulmonary HTN and pulmonary
thromboembolism
9) Fibreoptic bronchoscopy (FOB):
• Localise the site of bleeding
• Visualise endobronchial lesions
if massive bleeding – rigid bronchoscopy
(permits better visualisation of central airways
and better suctioning )
TREATMENT
Minor hemoptysis:
Scanty ( blood streaked sputum) - <100 ml/ 24 hrs
Resolve spontaneously without specific therapy
Treatment of underlying cause
Complete bed rest, cough
suppressants,tranexamic
acid,ethamsylate,sedative.
Massive hemoptysis:
• Huge amt of blood loss : >100-600 ml over 24 hrs
Stabilization:
 Ensure adequate ventilation and perfusion
 Avoid asphyxiation
 Lateral decubitus position
 oxygen
 Patients with poor gas exchange, rapid ongoing
hemoptysis, hemodynamic instability, or severe
shortness of breath should be orally intubated
with a large bore endotracheal tube
 Monitoring of BP, pulse rate, respiratory rate and
urine output
MASSIVE HEMOPTYSIS
Large IV access + Fluid resuscitation
Blood transfusions
Cough-suppressing drugs can be added.
Coagulation disorders should be rapidly
reversed
Protection of non-bleeding lung:
• Placement of bleeding lung in dependant
position- lateral decubitus ( if origin of bleed is
known and limited to 1 lung)
• Selective intubation of the nonbleeding lung
with bronchoscopic guidance ( isolate rt. and
lt. mainstem bronchi)
• Placement of a double lumen ETT specially
designed for selective intubation of the right
or left mainstem bronchi
• Emergency bronchoscopy – cold saline lavage
Endobronchial tamponade:
• Balloon catheter is introduced via
bronchoscopy and inflated to occlude the
bronchus(prevents aspiration of blood into
unaffected areas and also stops the bleeding)
• The balloon is left inflated for 24 to 48 hours,
and the patient is then observed for
rebleeding with the balloon deflated for
several hours
Bronchial arterial embolization:
• Angiography should be performed initially
• Vessel proximal to bleeding site is cannulated and
material like gelfoam – injected to occlude the
vessel
• Used as a semi-definitive treatment option or a
bridge to elective surgery.
• 85% of the time the bleeding stops after
embolization
• 10-20% of patients rebleed in the following 6-12
months
• Complication: embolization of the spinal artery
Other methods to control bleeding:
• Phototherapy
• Electrocautery
• Argon plasma coagulation
• Nd-YAG laser
SURGICAL MANAGEMENT
• Done in pts. with uncontrolled life-threatening
hemoptysis or localized disease subject to
recurrent bleeding
• Resection of bleeding lobe or lung maybe done
• Relative contraindications to surgery are: severe
underlying pulmonary disease, active TB, cystic
fibrosis, multiple AVMs, multifocal bronchiectasis,
and diffuse alveolar hemorrhage.
Approach to haemoptysis (2) copy.pptx

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Approach to haemoptysis (2) copy.pptx

  • 1. APPROACH TO HEMOPTYSIS Professor (Dr.)N.K.Sit. MBBS.DCH.MD(chest) Professor &Head Dept of Respiratory Medicine Rampurhat Govt. Medical College.
  • 2. DEFINITION • Hemoptysis is the expectoration of blood and it can range from blood-streaking of sputum to the presence of gross blood in the absence of any accompanying sputum. • The term massive hemoptysis is reserved for bleeding that is potentially life-threatening. • It has been defined by a number of different criteria, often ranging from more than 100 to more than 600 ml of blood over a 24 hour period.
  • 3. CAUSES OF HEMOPTYSIS 1. INFLAMMATORY Pulmonary Tuberculosis Chronic bronchitis Bronchiectasis Lung abscess Pneumonia( klebsiella) Parasitic (Paragonimiasis) Fungal (Mycetoma)
  • 4. 2.NEOPLASTIC Bronchogenic carcinoma. Bronchial adenoma. Endobronchial metastasis. Carcinoid tumor 3.CARDIOVASCULAR Mitral stenosis Pulmonary Thromboembolism LVF Primary Pulmonary Hypertension
  • 5. Eisenmengers syndrome. Arteriovenous malformation. 4.TRAUMATIC Foreign body. Lung contusion. Blunt/Penetrating chest injury. Bronchial disruption. Bronchoscopies. Lung Biopsies.
  • 6. 5.PULMONARY VASCULITIS Wegners granulomatosis Goodpasture’s syndrome Systemic lupus erythematosus 6.Miscellaneous Pulmonary amyloidosis Idiopathic pulmonary haemosiderosis Broncholiths Bleeding diathesis
  • 7. Munchausen syndrome Catamenial haemoptysis. Congenital ( bronchial cyst, sequestration) 6) Drugs Anticoagulents Cocaine Penicillamine Amiodarone
  • 9. DIFFERENTIATING FEATURE OF HAEMOPTYSIS AND HAEMATEMESIS • HAEMOPTYSIS HAEMATEMESIS • HISTORY • Absence of nausea and Presence of nausea and vomiting vomiting. Lung disease. Gastric or hepatic disease Asphyxia possible. Asphyxia unusual. SPUTUM EXAMINATION Frothy, Liquid or clotted Rarely frothy, coffy appearance, Bright red or pink ground in appearance In colour brown to black in colour
  • 10. • INVESTIGATION Alkaline ph Acidic ph Mixed with macrophage Mixed with food And neutrophil. Particle.
  • 11. HISTORY 1) Age: • Children – foreign body, bronchiectasis, pulmonary tuberculosis, pneumonia • Adults – tuberculosis, bronchiectasis, • Old age – bronchogenic carcinoma 2) Risk factors: • Smoking • Asbestos exposure • Contact with TB pt Bronchogenic Ca
  • 12. 3) Associated symptoms: • Blood-streaking of mucopurulent or purulent sputum  bronchitis • If accompanied by fever or chills – pneumonia • Putrid smell to sputum – lung abscess • Chronic and copious sputum production- bronchiectasis • Assoc. acute onset of pleuritic chest pain and dyspnoea – pulmonary embolism • Dyspnoea and other cardiac symptoms – mitral stenosis
  • 13. 4) Previous /co-existing disorders: • Renal disease ( Goodpasture’s syndrome, Wegener’s granulomatosis) • Lupus erythematosus( with asso. Pulmonary h’age from lupus pneumonitis) • Malignancy (recurrent lung Ca or endobronchial metastasis from non-pulmonary tumour) • Bleeding disorders- bleeding from other sites • AIDS pts- endobronchial or pulmonary parenchymal Kaposi’s sarcoma
  • 14. 5) Treatment History: • Any malignancy • Recent chemotherapy • Bone marrow transplant • Anticoagulants 6) H/o Trauma: • Gun-shot wounds • Fracture of ribs
  • 15. PHYSICAL EXAMINATION 1) Respiratory system: Pleural friction rub – pulmonary embolism Localised or diffuse crepitations : parenchymal bleeding Evidence of airflow obstruction: chr. Bronchitis
  • 16. 2) Cardiovascular system: • Findings of pulmonary artery HTN , mitral stenosis ( OS, mid-diastolic murmur) 3) Skin and mucosa: • Kaposi’s sarcoma • SLE lesions • Splinter hemorrhages- endocarditis or vasculitis
  • 17. INVESTIGATIONS 1) Complete Blood Count- Hb, TC, DLC,ESR, platelet count, bld gp 2) Coagulation profile 3) Urine analysis – red cells and red cell casts 4) Blood urea nitrogen and creatinine levels 5) Sputum : • Z-N staining – acid fast bacilli ( PTB) • Gram staining • Cytological examination- malignant cells • Culture – isolation of organisms
  • 18. 6) Chest X-Ray : ( PA and lateral) • Cystic lesions, tram tracks, ring shadows - bronchiectasis • Distinct air- fluid level: lung abscess  Mass lesion  Focal or diffuse parenchymal disease- pneumonia  Tubercular fluffy opacity. 7) CT scan: • Carcinoma • Bronchiectasis- diagnostic procedure of choice • Lung abscess
  • 19. 8) ECHO: • MS, pulmonary HTN and pulmonary thromboembolism 9) Fibreoptic bronchoscopy (FOB): • Localise the site of bleeding • Visualise endobronchial lesions if massive bleeding – rigid bronchoscopy (permits better visualisation of central airways and better suctioning )
  • 20.
  • 21. TREATMENT Minor hemoptysis: Scanty ( blood streaked sputum) - <100 ml/ 24 hrs Resolve spontaneously without specific therapy Treatment of underlying cause Complete bed rest, cough suppressants,tranexamic acid,ethamsylate,sedative. Massive hemoptysis: • Huge amt of blood loss : >100-600 ml over 24 hrs
  • 22. Stabilization:  Ensure adequate ventilation and perfusion  Avoid asphyxiation  Lateral decubitus position  oxygen  Patients with poor gas exchange, rapid ongoing hemoptysis, hemodynamic instability, or severe shortness of breath should be orally intubated with a large bore endotracheal tube  Monitoring of BP, pulse rate, respiratory rate and urine output MASSIVE HEMOPTYSIS
  • 23. Large IV access + Fluid resuscitation Blood transfusions Cough-suppressing drugs can be added. Coagulation disorders should be rapidly reversed
  • 24. Protection of non-bleeding lung: • Placement of bleeding lung in dependant position- lateral decubitus ( if origin of bleed is known and limited to 1 lung) • Selective intubation of the nonbleeding lung with bronchoscopic guidance ( isolate rt. and lt. mainstem bronchi) • Placement of a double lumen ETT specially designed for selective intubation of the right or left mainstem bronchi • Emergency bronchoscopy – cold saline lavage
  • 25. Endobronchial tamponade: • Balloon catheter is introduced via bronchoscopy and inflated to occlude the bronchus(prevents aspiration of blood into unaffected areas and also stops the bleeding) • The balloon is left inflated for 24 to 48 hours, and the patient is then observed for rebleeding with the balloon deflated for several hours
  • 26. Bronchial arterial embolization: • Angiography should be performed initially • Vessel proximal to bleeding site is cannulated and material like gelfoam – injected to occlude the vessel • Used as a semi-definitive treatment option or a bridge to elective surgery. • 85% of the time the bleeding stops after embolization • 10-20% of patients rebleed in the following 6-12 months • Complication: embolization of the spinal artery
  • 27. Other methods to control bleeding: • Phototherapy • Electrocautery • Argon plasma coagulation • Nd-YAG laser
  • 28. SURGICAL MANAGEMENT • Done in pts. with uncontrolled life-threatening hemoptysis or localized disease subject to recurrent bleeding • Resection of bleeding lobe or lung maybe done • Relative contraindications to surgery are: severe underlying pulmonary disease, active TB, cystic fibrosis, multiple AVMs, multifocal bronchiectasis, and diffuse alveolar hemorrhage.