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Presented by Md. Sakib Al Hasan
ID: 20PHR019
Department of Pharmacy, BSMRSTU.
Bangabandhu Sheikh Mujibur Rahman Science and Technology University.
PHENOLIC COMPOUNDS
AND TANNINS
(With a new Dimension of Pharmacognosy and its Research Area)
Fig-1: Fraga-Corral et al., 2021.
Purposes of Pharmacognosy Study
Fig: Anti-microbial test in Pharmacy
Department, BSMRSTU
Fig: Clot lysis and membrane stability
test of canna indica flower water extract
in Pharmacy Department, BSMRSTU.
Medicinal Plant
Identification and
Classification
Toxicology
Bioactivity Assessment
antimicrobial
antioxidant
anticancer
Fig: Brine Shrimp toxicity test in
Pharmacy Department, BSMRSTU.
Drug Discovery
and Development
Tannins are polyphenolic
substances found in many plants product of
higher molecular weight, but < 500
(According to lipinski's rule of five).
They are soluble in dilute alkalis, alcohol,
glycerol and acetone, but only sparingly
soluble in other organic solvents and non-
crystallisable compounds.
Tannin classified mainly two types, these
are true tannin and pseudo tannins.
Plants contain many active compounds that
are used in APIs (active pharmaceutical
ingredients).
White catechu is a type of plant that contains
tannin, a phytochemical class.
This plant contains mainly two active
compounds: catechins and quercetin.
Black catechu is approximately same as the
white catechu.
Nutgall is a type of plant that contains
tannin, a phytochemical class.
This plant contains mainly gallotannic
acid (tannic acid).
Gallotannic acid can converts into
Gallic acid.
About Gallic Acid in Neurobiological
Activity:
Bhuia, M. S., Rahaman, M. M., Islam, T., Bappi, M. H., Sikder, M. I., Hossain, K.
N., Akter, F., Al Shamsh Prottay, A., Rokonuzzman, M., Gürer, E. S., Calina, D.,
Islam, M. T., & Sharifi-Rad, J. (2023). Neurobiological effects of gallic acid:
current perspectives. Chinese medicine, 18(1), 27.
https://doi.org/10.1186/s13020-023-00735-7
Quercetin
Quercetin is lipophilic and can cross
blood brain barrier.
Quercetin has many pharmacological
activity.
PubMed has 26,518 results about this.
Article about Quercetin from Department of Pharmacy,
BSMRSTU:
1. Islam, M. S., Hossain, R., Ahmed, T., Rahaman, M. M., Al-Khafaji, K., Khan, R. A., Sarkar,
C., Bappi, M. H., de Andrade, E. M., Araújo, I. M., Coutinho, H. D. M., Kowalska, G.,
Kowalski, R., Hanif, M. A., & Islam, M. T. (2022). Anxiolytic-like Effect of Quercetin
Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico
Studies. Molecules (Basel, Switzerland), 27(21), 7149.
https://doi.org/10.3390/molecules27217149
2. Bappi, M. H., Prottay, A. A. S., Kamli, H., Sonia, F. A., Mia, M. N., Akbor, M. S., Hossen,
M. M., Awadallah, S., Mubarak, M. S., & Islam, M. T. (2023). Quercetin Antagonizes the
Sedative Effects of Linalool, Possibly through the GABAergic Interaction Pathway.
Molecules (Basel, Switzerland), 28(14), 5616. https://doi.org/10.3390/molecules28145616
Thank You
Any Question???

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Tanin Presentation- Md. Sakib Al Hasan Rafi.pptx

  • 1. Presented by Md. Sakib Al Hasan ID: 20PHR019 Department of Pharmacy, BSMRSTU. Bangabandhu Sheikh Mujibur Rahman Science and Technology University. PHENOLIC COMPOUNDS AND TANNINS (With a new Dimension of Pharmacognosy and its Research Area)
  • 3. Purposes of Pharmacognosy Study Fig: Anti-microbial test in Pharmacy Department, BSMRSTU Fig: Clot lysis and membrane stability test of canna indica flower water extract in Pharmacy Department, BSMRSTU. Medicinal Plant Identification and Classification Toxicology Bioactivity Assessment antimicrobial antioxidant anticancer Fig: Brine Shrimp toxicity test in Pharmacy Department, BSMRSTU. Drug Discovery and Development
  • 4. Tannins are polyphenolic substances found in many plants product of higher molecular weight, but < 500 (According to lipinski's rule of five). They are soluble in dilute alkalis, alcohol, glycerol and acetone, but only sparingly soluble in other organic solvents and non- crystallisable compounds. Tannin classified mainly two types, these are true tannin and pseudo tannins.
  • 5. Plants contain many active compounds that are used in APIs (active pharmaceutical ingredients). White catechu is a type of plant that contains tannin, a phytochemical class. This plant contains mainly two active compounds: catechins and quercetin. Black catechu is approximately same as the white catechu.
  • 6. Nutgall is a type of plant that contains tannin, a phytochemical class. This plant contains mainly gallotannic acid (tannic acid). Gallotannic acid can converts into Gallic acid. About Gallic Acid in Neurobiological Activity: Bhuia, M. S., Rahaman, M. M., Islam, T., Bappi, M. H., Sikder, M. I., Hossain, K. N., Akter, F., Al Shamsh Prottay, A., Rokonuzzman, M., Gürer, E. S., Calina, D., Islam, M. T., & Sharifi-Rad, J. (2023). Neurobiological effects of gallic acid: current perspectives. Chinese medicine, 18(1), 27. https://doi.org/10.1186/s13020-023-00735-7
  • 7. Quercetin Quercetin is lipophilic and can cross blood brain barrier. Quercetin has many pharmacological activity. PubMed has 26,518 results about this. Article about Quercetin from Department of Pharmacy, BSMRSTU: 1. Islam, M. S., Hossain, R., Ahmed, T., Rahaman, M. M., Al-Khafaji, K., Khan, R. A., Sarkar, C., Bappi, M. H., de Andrade, E. M., Araújo, I. M., Coutinho, H. D. M., Kowalska, G., Kowalski, R., Hanif, M. A., & Islam, M. T. (2022). Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies. Molecules (Basel, Switzerland), 27(21), 7149. https://doi.org/10.3390/molecules27217149 2. Bappi, M. H., Prottay, A. A. S., Kamli, H., Sonia, F. A., Mia, M. N., Akbor, M. S., Hossen, M. M., Awadallah, S., Mubarak, M. S., & Islam, M. T. (2023). Quercetin Antagonizes the Sedative Effects of Linalool, Possibly through the GABAergic Interaction Pathway. Molecules (Basel, Switzerland), 28(14), 5616. https://doi.org/10.3390/molecules28145616