Md. Abdul Muhit is an Assistant Professor in the Department of Clinical Pharmacy and Pharmacology at the University of Dhaka in Bangladesh. He received his PhD from the University of Shizuoka in Japan, where he studied the estrogenic and anti-estrogenic properties of compounds isolated from Bangladeshi plants. His research has resulted in over 25 publications. He teaches pharmacognosy and pharmacology and supervises student research.
Phytocomponents in methanolic extract of Euphorbia hirta, leaf was studied using GC MS
analysis. Ten compounds were identified from the extract. The major chemical constituents were Niacin or
Nicotinic acid [Peak area: 31.70% ; RT: 22.718;Mol formula:C6H5NO2],S-methyl-L-cysteine [Peak area:
18.88%; RT: 21.794; Mol formula:C4H9NO2S], Methyl 1,4-methylpentadecanoate [Peak area :11.22% ; RT:
19.326; Mol formula:C17H34O2], 2-amino-3-sulfanylpropanoic acid [Peak area: 5.16%; RT: 21.682; Mol
formula:C3H7NO2S], 4-amino-4-oxobut-2-enoic acid [Peak area: 4.02%; RT: 23.118; Mol formula:C4H5NO3].
The bioactive compounds in the methanol leaf extract of Euphorbia hirta, exhibited phytopharmacological
significance and hence could be beneficial for therapeutic use against some health challenges.
ABSTRACT- Valeriana jatamansii Linn (Valerianaceae) is a medicinal herb used in the traditional health care system of
Uttarakhand (India). The present study reports the anticonvulsant activities in the aqueous and ethanolic extracts of the
roots of Valeriana jatamansii on the rats, induced both chemically and electrically. The models chosen for the activity
were Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced convulsions in rats. The test dose studied were
400 and 600 mg/kg body weight orally of the extracts. Acute toxicity studies show that the extracts were non toxic up to
the recommended dose 2000mg/kg body weight orally as per OECD guideline no 423. In PTZ induced seizures, onset of
clonic convulsions were studied while in MES model, reduction in the mean duration of extensor phase was noted. Both
the extracts showed anticonvulsant activities against MES and PTZ animal models.
Key Words: Anticonvulsant activity, MES, PTZ, Herbal drug
Phytocomponents in methanolic extract of Euphorbia hirta, leaf was studied using GC MS
analysis. Ten compounds were identified from the extract. The major chemical constituents were Niacin or
Nicotinic acid [Peak area: 31.70% ; RT: 22.718;Mol formula:C6H5NO2],S-methyl-L-cysteine [Peak area:
18.88%; RT: 21.794; Mol formula:C4H9NO2S], Methyl 1,4-methylpentadecanoate [Peak area :11.22% ; RT:
19.326; Mol formula:C17H34O2], 2-amino-3-sulfanylpropanoic acid [Peak area: 5.16%; RT: 21.682; Mol
formula:C3H7NO2S], 4-amino-4-oxobut-2-enoic acid [Peak area: 4.02%; RT: 23.118; Mol formula:C4H5NO3].
The bioactive compounds in the methanol leaf extract of Euphorbia hirta, exhibited phytopharmacological
significance and hence could be beneficial for therapeutic use against some health challenges.
ABSTRACT- Valeriana jatamansii Linn (Valerianaceae) is a medicinal herb used in the traditional health care system of
Uttarakhand (India). The present study reports the anticonvulsant activities in the aqueous and ethanolic extracts of the
roots of Valeriana jatamansii on the rats, induced both chemically and electrically. The models chosen for the activity
were Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced convulsions in rats. The test dose studied were
400 and 600 mg/kg body weight orally of the extracts. Acute toxicity studies show that the extracts were non toxic up to
the recommended dose 2000mg/kg body weight orally as per OECD guideline no 423. In PTZ induced seizures, onset of
clonic convulsions were studied while in MES model, reduction in the mean duration of extensor phase was noted. Both
the extracts showed anticonvulsant activities against MES and PTZ animal models.
Key Words: Anticonvulsant activity, MES, PTZ, Herbal drug
Medicinal value of plant Momordica charatia including its nomenclature, habit and habitat, cultivation and collection, Macro and Microscopic characteristics, phytochemical constituents and its pharmacological action.
OVERVIEW OF PHYTOCHEMISTRY AND PHARMACOLOGY OF CHICKPEAS (PHASEOLUS VULGARIS)Harrizul Rivai
This review aims to provide basic knowledge of the medicinal plant Chickpeas (Phaseolus vulgaris). Currently, Chickpeas are considered a medicinal plant for diabetes mellitus. However, natural compounds for treating diabetes mellitus are the most alternative and complementary therapies due to their various biological and therapeutic properties. We conducted a limited, open search in English from the Mendeley, Google Scholar, Scopus, Web of Science, and Pubmed databases for all available literature from 2000-2020, using terms related to phytochemical, pharmacological and Phaseolus vulgaris compounds. This view of the phytochemical content and pharmacological activity of Phaseolus vulgaris provides a solid basis for developing new treatments. Chickpeas (Phaseolus vulgaris L) have several bioactive components associated with health benefits, such as alkaloids, anthocyanins, carbohydrates, catechins, fiber, and flavonoids phytic acid, quercetin, saponins, steroids, tannins, and terpenoids and trypsin inhibitors. Therefore, Chickpeas have various biological activities, including analgesic, anti-inflammatory, antibacterial, antidiabetic, diuretic, antioxidant, hypocholesterolemic, and antiobesity. Also, Chickpeas (Phaseolus vulgaris) have been shown to have vigorous antidiabetic activity and may be useful in developing new antidiabetic therapies.
Medicinal value of plant Momordica charatia including its nomenclature, habit and habitat, cultivation and collection, Macro and Microscopic characteristics, phytochemical constituents and its pharmacological action.
OVERVIEW OF PHYTOCHEMISTRY AND PHARMACOLOGY OF CHICKPEAS (PHASEOLUS VULGARIS)Harrizul Rivai
This review aims to provide basic knowledge of the medicinal plant Chickpeas (Phaseolus vulgaris). Currently, Chickpeas are considered a medicinal plant for diabetes mellitus. However, natural compounds for treating diabetes mellitus are the most alternative and complementary therapies due to their various biological and therapeutic properties. We conducted a limited, open search in English from the Mendeley, Google Scholar, Scopus, Web of Science, and Pubmed databases for all available literature from 2000-2020, using terms related to phytochemical, pharmacological and Phaseolus vulgaris compounds. This view of the phytochemical content and pharmacological activity of Phaseolus vulgaris provides a solid basis for developing new treatments. Chickpeas (Phaseolus vulgaris L) have several bioactive components associated with health benefits, such as alkaloids, anthocyanins, carbohydrates, catechins, fiber, and flavonoids phytic acid, quercetin, saponins, steroids, tannins, and terpenoids and trypsin inhibitors. Therefore, Chickpeas have various biological activities, including analgesic, anti-inflammatory, antibacterial, antidiabetic, diuretic, antioxidant, hypocholesterolemic, and antiobesity. Also, Chickpeas (Phaseolus vulgaris) have been shown to have vigorous antidiabetic activity and may be useful in developing new antidiabetic therapies.
Terry Exports LLP (TEL) is an Indian based premium moringa powder exports-oriented firm, which promotes, market and distributes moringa oleifera products of the highest quality to pharmaceutical/nutraceuticals, cosmetic, personal care, wellness, food, beverage and spa industries in the USA, Europe.
Moringa is a plantfood of high nutritional value, ecologically and economically beneficial and readily available in the countries hardest hit by the food crisis. http://miracletrees.org/ http://moringatrees.org/
Now a days everybody wants evidence or proof for any purpose.so govt.of india introduces AYUSH research portal for the devalopment and taking awareness regarding ayurveda where it consists of clinical trial and pre-clinical trial data.
1. Md. Abdul Muhit
Assistant Professor, Department of Clinical Pharmacy and Pharmacology
Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
TEL: +88-01733-982854
E-mail: muhit@du.ac.bd
EDUCATION
PhD Candidate in Pharmaceutical Science, September 2016
University of Shizuoka, Graduate School of Pharmaceutical Sciences, Shizuoka, Japan
Dissertation title: Estrogenic and/or anti-estrogenic constituents from Terminalia
citrina and Pothos scandens.
Reported 39 novel compounds among which 10 polyalkoylated lignans, 25
lignan monoglucosides containing furofuran, 4-oxofurofuran and
tetrahydrofuran rings, 3 hemiterpene glycosides, a phenylisobutanoid along
with 40 other known compounds
Evaluated estrogenic and/or anti-estrogenic properties of the isolates using
estrogen responsive breast cancer cell lines T47D and MCF-7.
Advisors: Prof. Shigeru Itai and Dr. Kaoru Umehara
Masterof Pharmacy in Clinical Pharmacy and Pharmacology, August 2008
University of Dhaka, Department of Clinical Pharmacy and Pharmacology, Faculty of
Pharmacy, Dhaka, Bangladesh
Thesis title: Phytochemical and biological investigations of Abutilon indicum.
Isolated three phytosteroids and characterized them by comparing with
published 1H-NMR data
Evaluated antioxidant, antimicrobial and brine shrimp lethality bioassay of
variety of crude extracts.
Advisor: Prof. Md. Saiful Islam
Bachelor of Pharmacy in Pharmaceutical Sciences, August 2006
University of Dhaka, Faculty of Pharmacy, Dhaka, Bangladesh
PROFESSIONAL EXPERIENCE
Assistant Professor, Department of Clinical Pharmacy & Pharmacology, Faculty of
Pharmacy, University of Dhaka, Bangladesh, November 12, 2013 to present
Lecturer, Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy,
University of Dhaka, Bangladesh, January 20, 2011 to November 11, 2013
2. Md. Abdul Muhit, Page 2
Lecturer, Department of Pharmacy, University of Rajshahi, Bangladesh, January 02, 2010
to January 19, 2011
Lecturer, Department of Pharmacy, East West University, Bangladesh, September 03,
2008 to January 01, 2010
PUBLICATION
2016
26. M. A. Muhit, K. Umehara, and H. Noguchi. Five furofuranone lignan glucosides
from Terminalia citrina inhibit in vitro E2-enhanced breast cancer cell proliferation. (Under
review in Fitoterapia – Impact Factor 2.4)
25. M. A. Muhit, K. Umehara, and H. Noguchi. Furofuran lignan glucosides with
estrogen-inhibitory properties from Bangladeshi medicinal plant Terminalia citrina.
Journal of Natural Products, 2016, 79, 1298-1307. DOI: 10.1021/acs.jnatprod.5b01042
(Imapct Factor 3.8)
24. M. A. Muhit, M. Izumikawa, K. Umehara, and H. Noguchi. Phenolic constituents
of the Bangladeshi medicinal plant Pothos scandens and their anti-estrogenic,
hyaluronidase inhibition, and histamine release inhibitory activities. Phytochemistry, 2016,
121, 30-37. DOI: 10.1016/j.phytochem.2015.10.009 (Impact factor 2.6)
2014
23. M. M. Rahman, J. K. Chakrabarty, M. A. Muhit, and P. R. Das, Evaluation of
analagesic activity of the different fractions of Typha elephantina Roxb. International
Journal of Pharmacognosy, 2014, 1(6), 380-383
2013
22. D. Goshwami, M. M. Rahman, M. A. Muhit, and M. S. Islam. Antinociceptive,
anti-inflammatory and antipyretic activities of methanolic extract of Lasia spinosa leaves.
International Journal of Pharmaceutical and Chemical Sciences, 2013, 2(1), 118-122
21. D. Goshwami, M. M. Rahman, M. A. Muhit, and M. S. Islam. In vitro evaluation of
anthelmintic activity of Lasia spinosa leaves. International Journal of Current
Pharmaceutical Research, 2013, 5(1), 34-35
2012
20. U. K. Karmakar, S. K. Biswas, A. Chowdhury, S. Z. Raihan, M. A. Akbar, M. A.
Muhit, and R. Mowla. Phytochemical investigations and evaluation of antimicrobial and
antioxidant potentials of Asparagus racemosus. International Journal of Pharmacology
2012, 8(1), 53-57. (Impact factor 1.50)
19. S. Monira, A. Haque, M. A. Muhit, N.C. Sarker, A.H.M.K. Alam, A.A. Rahman,
and P. Khondkar. Antimicrobial, antioxidant and cytotoxic properties of Hypsizygus
3. Md. Abdul Muhit, Page 3
tessulatus cultivated in Bangladesh. Research Journal of Medicinal Plants, 2012, 6(4), 300-
308
18. M. A. Muhit, M. O. Rahman, S. Z. Raihan, M. Asaduzzaman, M. A. Akbar, N.
Sharmin, and A. B. M. Faroque. Cardiovascular disease prevalence and prescription
patterns at a tertiary level hospital in Bangladesh. Journal of Applied Pharmaceutical
Science, 2012, 2(3): 80-84
17. S.K. Biswas, A. Chowdhury, J. Das, A. Chowdhury, S.Z. Raihan, M.A. Muhit.
Phytochemical investigation with assessment of cytotoxicity and antimicrobial activities of
the ethanol extract of Elaeocarpus serratus. American Journal of Plant Physiology, 2012,
7(1): 47-52
16. S.K. Biswas, A. Chowdhury, S.Z. Raihan, M.A. Muhit, M. A. Akbar, and R.
Mowla. Phytochemical investigation with assessment of cytotoxicity and antimicrobial
activities of chloroform extract of the leaves of Kalanchoe pinnata. American Journal of
Plant Physiology, 2012, 7(1): 41-46
15. D. Goshwami, M. M. Rahman, M. A. Muhit, and M. S. Islam. Antinociceptive
activity of leaves of Lasia spinosa. Archives of Applied Science Research, 2012, 4(6),
2431-2434
14. M. A. Milon, M. A. Muhit, D. Goshwami, M. M. Masud, and B. Begum.
Antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba bark. International
Journal of Pharmaceutical Sciences and Research, 2012, 3(7), 2233-2237
13. D. Goshwami, M. M. Rahman, M. A. Muhit, M. S. Islam, and M. Ansari.
Antioxidant property, cytotoxicity, and antimicrobial property of Lasia spinosa leaves.
Nepal Journal of Science and Technology, 2012, 13(2), 215-218
12. J. Das, A. Chowdhury, S. K. Biswas, U. K. Karmakar, S. R. Sharif, S. Z. Raihan
and M. A. Muhit. Cytotoxicity and antifungal activities of ethanolic and chloroform
extracts of Cucumis sativus Linn (Cucurbitaceae) leaves and stems. Research Journal
Phytochemistry, 2012, 6(1), 25-30
11. A. S. Apu, S. H. Bhuyan, S. S. Prova and M. A. Muhit. Anti-inflammatory activity
of medicinal plants native to Bangladesh: A review. Journal of Applied Pharmaceutical
Science, 2012, 2(2), 7-10
2011
10. S. Parvin, M. A. Kader, M. A. Muhit, M. E. Haque, M. A. Mosaddik, and M. I. I.
Wahed. Triterpenoids and phytosteroids from the stem bark of Crataeva nurvala buch ham.
Journal of Applied Pharmaceutical Science, 2011, 1 (9), 47-50
9. A. Roy, S. K. Biswas, A. Chowdhury, M. C. Shil, S. Z. Raihan, and M. A. Muhit.
Phytochemical screening, cytotoxicity and antibacterial activities of two Bangladeshi
medicinal plants. Pakistan Journal of Biological Sciences, 2011, 14(19), 905-908 PMID:
22518935
4. Md. Abdul Muhit, Page 4
8. M. Asaduzzaman, N. Nasrin, M. A. Muhit, S. Z. Raihan, A. S. Apu, and A. Akbar.
Antidiarrheal, analgesic and cytotoxic activities of crude extract of Oroxylum indicum (L.)
stem bark. Journal of Pharmacy Reserach, 2011, 4(11): 4296-4298
7. M. A. Akbar, M. Mawla, M. A. Khan, T. Hye, M. Asaduzzaman, and M. A. Muhit.
In vitro dissolution studies of different brands of sustained release Metformin
hydrochloride matrix solid dosage forms available in the pharmaceutical market of
Bangladesh. Journal of Pharmacy Reserach, 2011, 4(10): 3436-3438
6. M. Asaduzzaman, A. H. Pathan, N. Nasrin, A. S. Apu, A. T. M. Jamaluddin, Z.
Rahman, M. A. Muhit, and M. Ahmed. Drug use pattern in selected health complex and
hospitals in Bangladesh. SGH Medical Journal, 2011, 5(1): 19-26
2010
5. M. A. Muhit, S. S. Khanam, M. S. Islam, M. S. Rahman, and B. Begum.
Phytochemical and biological investigations of Pterospermum acerifolium wild bark.
Journal of Pharmacy Research, 2010, 3(11), 2643-2646
4. M. A. Muhit, M. O. Rahman. Reducing polypharmacy in migraine: an overview.
Journal of Pharmacy Reserach, 2010, 3(9): 2248-2250
3. A. S. Apu, M. A. Muhit, S. M. Tareq, A. H. Pathan, A. T. M. Jamaluddin, and M.
Ahmed. Antimicrobial activity and brine shrimp lethality bioassay of the leaves extract of
Dillenia indica. Journal of young pharmacist, 2010, 2(1), 50-53, PMID: 21331191
2. M. A. Muhit, A. S. Apu, M. S. Islam and M. Ahmed. Cytotoxic and antimicrobial
activity of the crude extract of Abutilon indicum. International Journal of Pharmacognosy
and Phytochemical Research, 2010, 2(1), 1-4. (Impact factor 1.34)
1. M. A. Muhit, S. M. Tareq, A. S. Apu, D. Basak, and M. S. Islam. Isolation and
identification of compounds from the leaf extract of Dillenia indica Linn. Bangladesh
Pharmaceutical Journal, 2010, 13(1), 49-53
POSTER PRESENTATION
4. M. A. Muhit, K. Umehara, and H. Noguchi. Anti-estrogenic lignan monoglucosides
from Terminalia Citrina. 62nd Annual Meeting of Japan Society of Pharmacognosy. Gifu,
Japan, September- 2015
3. M. A. Muhit, M. Izumikawa, K. Umehara, and H. Noguchi. Estrogenic and/or anti-
estrogenic constituents from Pothos scandens. 135th Annual Meeting of the Pharmaceutical
Society of Japan. Kobe, Japan, March-2015
2. H. Kobayashi, M. A. Muhit, K. Umehara, and H. Noguchi. Estrogenic and/or anti-
estrogenic constituents from Terminalia citrina. 135th Annual Meeting of the
Pharmaceutical Society of Japan. Kobe, Japan, March-2015
5. Md. Abdul Muhit, Page 5
1. M.A. Muhit, K. Umehara and H. Noguchi. Estrogenic and/or anti-estrogenic
constituents from Bangladeshi medicinal plant Pothos scandens. 11th Japan-China
International Symposium on Health Sciences. Shizuoka, Japan, November-2014
GRANTS AND AWARDS
Monbukagakusho (MEXT) Scholarship for PhD studies, from the Ministry of Education,
Culture, Sports, Science and Technology, Japan. September-2013
Grant from University Grants Commission, Bangladesh for conducting research on
Bangladeshi Medicinal Plants. July-2012 (97,500/- BDT)
Scholarship from Ministry of Education, Bangladesh for studying Bachelor of Pharmacy
and Master of Pharmacy courses, 2000-2005
INDUSTRIAL TRAINING
Completed one month training in the Pharmaceutical Production unit at BEXIMCO
Pharmaceuticals Co. Ltd. Bangladesh, 2006
OTHER ACTIVITIES
Writing op-ed in daily newspapers about national and international activities
Advisor of student forum ‘NYN’ (Network of Young Nilphamarian) and Social Club of
Pharmacy Students, University of Dhaka
Served as Teaching Assistant for English language at Shizuoka Municipality High School
QUALIFICATION
Registered Grade ‘A’ Pharmacist (A-2805, Bangladesh Pharmacy Council)
MEMBERSHIP
Pharmaceutical Society of Japan
Japan Society of Pharmacognosy
Dhaka University Teacher’s Association
Japanese Universities Alumni Association of Bangladesh (JUAAB)
Bangladesh Pharmaceutical Society
REFERENCES
Shigeru Itai, Professor, Laboratory of Pharmaeutical Engineering and Drug delivery
science, School of Pharmaceutical Sciences, University of Shizuoka, Japan. E-mail: s-
itai@u-shizuoka-ken.ac.jp, Web link: http://w3pharm.u-shizuoka-ken.ac.jp/pharmeng/en/
6. Md. Abdul Muhit, Page 6
Kaoru Umehara, Assistant Professor, Laboratory of Pharmacognosy, School of
Pharmaceutical Sciences, University of Shizuoka, Japan. E-mail: umehara@shizuoka-
ken.ac.jp
Md. Saiful Islam, Professor and Dean, Faculty of Pharmacy, University of Dhaka,
Bangladesh. E-mail: saifulpharmacy@yahoo.com