4.18.24 Movement Legacies, Reflection, and Review.pptx
PROSTHETIC VALVES
1.
2. DEFINITION
“Prosthetic heart valve is a device
implanted in the heart of a patient with
valvular heart disease.”
- Brunner & Suddarths (2012)
3. “A surgical implant used to replace an
abnormal heart valve. Most prosthetic valves
require open heart surgery. The implanted
valves can be porcine (from a pig) or
mechanical (man-made). Also known as
porcine heart valve, heart graft, mechanical
heart valve.”
- Jose Vega (2010)
7. MECHANICAL VALVES
CAGED BALL:-
The first artificial heart valve was the caged-ball, which
utilizes a metal cage to house a silicone elastomer ball.
When blood pressure in the chamber of the heart exceeds
that of the pressure on the outside of the chamber the ball
is pushed against the cage and allows blood to flow.
At the completion of the heart's contraction, the pressure
inside the chamber drops and is lower than beyond the
valve, so the ball moves back against the base of the valve
forming a seal.
8.
9. Advantages
Oldest prosthetic valve.
Durabilty upto 40 yr
Disadvantages
High profile
Hemolysis
High thrombogenecity
Poor hemodynamics in small sizes
Unique features
Occluder travels completely out of the orifice, reduces
thrombus & pannus growing from the sewing ring.
Continuously changing points of contact of the ball
reduces the wear & tear in any one area
Thrombogenic risk 4-6% per year.
10. TILTING DISC VALVE
Tilting disk valves have a single circular occluder controlled
by a metal strut.
They are made of a metal ring covered by an Eptfe fabric, into
which the suture threads are stitched in order to hold the
valve in place.
The metal ring holds, by means of two metal supports, a disc
which opens and closes as the heart pumps blood through
the valve.
The disc is usually made of an extremely hard carbon
material (pyrolytic carbon), in order to allow the valve to
function for years without wearing out.
11.
12. Advantages
Low profile
Good hemodynamics even in small sizes
Excellent durability
Permit central laminar flow.
Disadvantages
Anticoagulation mandatory
Higher risk of thrombosis than cage ball
Sudden catastrophic valve thrombosis.
13. BILEAFLET VALVES
They have two semicircular leaflets retained
within the ring by hinges. The potential for
impeded leaflet movement due to interference
with cardiac structures is slim, as the open leaflets
are positioned in the middle of the blood stream
and enclosed within the ring in the closed
position.
Bileaflet valves are the most protected as the
leaflets hardly protrude from the valve ring, even
during maximum opening.
14.
15. Advantages:-
Low bulk - flat profile.
Less thrombogenicy.
Central laminar flow.
Two semicircular discs that pivot between open
and closed positions.
No need for supporting struts.
Good hemodynamics even in small sizes.
2 lateral, 1 central minor orifice , no chance of
sudden catastro thrombosis.
Disadvantages:-
Anticoagulation mandatory risk of thrombosis.
16. TISSUE (BIOLOGICAL) HEART VALVES
Tissue valves (also called biologic or bioprosthetic
valves) are made of human or animal tissue. Some valves may
have some artificial parts to help give the valve support and
to aid placement. Once the tissue is removed from the
animal, it is chemically treated to preserve the tissue and
prevent immulogic reactions once it is placed in a patient.
There are three types of tissue valves:
pig tissue (porcine),
cow tissue (bovine), and
human (allografts or homografts).
17. Porcine Stented valves
The porcine stented valve was the first
generation of porcine tissue valves. They
have been available for more than 30 years.
The valves are made from natural porcine
aortic valves, but may be used for aortic or
mitral valve replacement. They are trimmed
and then fixed in buffered glutaraldehyde at
high pressure.
18.
19. Porcine stentless valve
The porcine stentless valve is used for aortic valve
replacement. The valve is made from a natural
porcine aortic valve and is fixed in buffered
glutaraldehyde solution at a low pressure.
No stents or synthetic sewing rings are used.
Therefore, these valves are very similar to the
homograft valve (see below).
These valves are technically more difficult to
implant but are useful in patients with small
hypertrophied hearts.
20.
21. Pericardial valves
The Carpentier-Edwards PERIMOUNT
Pericardial Bioprosthesis
Pericardial valves include the Perimount series
valves (Edwards LifeSciences). Ionescu-Shiley
pericardial valves have been discontinued. More
recently, stentless porcine valves have been used.
They offer improved hemodynamics with a
decreased transvalvular pressure gradient when
compared with older stented models.
22.
23. Other types of biological valves
Xenografts are tissue valves (eg,
bioprostheses, heterografts); most are
from pigs (porcine), but valves from cows
(bovine) may also be used. Their viability is
7 to 10 years.
They do not generate thrombi, thereby
eliminating the need for longterm
anticoagulation.
24. Homografts, or allografts (ie, human
valves), are obtained from cadaver tissue
donations.
The aortic valve and a portion of the aorta or
the pulmonic valve and a portion of the
pulmonary artery are harvested and stored
cryogenically.
Homografts are not always available and are
very expensive.
25. Autografts (ie, autologous valves) are obtained by
excising the p atient’s own pulmonic valve and a
portion of the pulmonary artery for use as the
aortic valve.
Anticoagulation is unnecessary because the valve
is the patient’s own tissue and is not
thrombogenic.
The autograft is an alternative for children (it may
grow as the child grows), women of childbearing
age, young adults, patients with a history of peptic
ulcer disease, and those who cannot tolerate
anticoagulation.
29. Fluoroscopy of a normally functioning CarboMedics
bileaflet prosthesis in mitral position
A=opening angle B=closing angle
30. MRI:
Not useful in assessing prosthetic-valve
structure
Used only when prosthetic-valve
regurgitation or para valvular leakage is
suspected but not adequately visualized by
echocardiography
31. Cardiac Catheterization:
Measure the transvalvular pressure
gradient, from which the EOA can be
calculated
Can visualize and quantify valvular or
paravalvular regurgitation
32. Echocardiography of Stentless
Aortic Homografts
Doppler flow characteristics similar to native valve.
Only 2-D evidence: Increased Echo intensity, and
Thickness of aortic annulus.
33. Valve dysfunction
complication example Role of echo
Primary mechanical failure Ball variance
Strut fracture
Visualize structure, assess
gradient & regurgitation
Nonstructural dysfunction Pt- prosthesis mismatch
pannus
Gradient, visualize tissue in
& around the sewing ring
Bleeding event Intracranial hge Source of embolus, presence
& mobility of masses
Endocarditis Vegetation, abcess,
dehiscence
Visualize area around the
sewing ring, echo dense /
lucent area, perivalvular
regurgitation
Thrombosis Thrombus impedes opening
&closing of occluder
mechanism
Localize mass, assess
gradient, detect
regurgitation
Embolism stroke Identify & characterize the
source of emboli
34. Patient-prosthesis mismatch
When the effective prosthetic valve area, after
insertion into the patient less than that of a normal
valve (Rahimtoola in 1978)
EOA indexed to BSA is less than 0.85 cm2/m2
EOA (echo) differs from geometric orifice area
(measured directly)
EOA for each prostheses type & size obtained in
literature from pts normally functioning prostheses
Average if > 1 value
-- mild (0.9 - 1 cm² /m²
-- moderate (0.6 - 0.9 cm2/m²
-- severe (iEOA < 0.6cm²/m² (Rahimtoola)
35. Three-step algorithm
Step 1: Calculation of the patient BSA.
Step 2: Reference to the specific table for
identification of the adequate valvular EOA
according to the patient BSA.
Step 3: Selection of the most appropriate
type and size of valve prosthesis according
to the target iEOA
36.
37. Valve thrombosis
Incidence of 0.1 to 5.7 % per patient/year
<0.2% per year for mechanical valves
<0.1% bioprosthetic valves
small thrombus, at the hinge portion of a bileaflet valve
obstruct the mechanism
tilting disk -- a much larger thrombus to prevent function
Ball and cage valves – less susceptible occluder has no
contact at all with the valve housing for a portion of every
cycle
Clinical
Non obstructive- incidental/embolic phenomenon
Partial obstruction- dyspnea,systemic embolism , fever
Severe obstruction- overt heart failure
38. Fibrinolytic therapy
Rt sided thrombosis 80-100% success rate
• Surgery for fibrinolysis failure/symptoms >
3 wk
Surgery – Lt sided thrombosis, large clot
burden
39. 2 types of protocol
-rescue fibrinolysis (short protocol for unstable pt)
- long protocol for stable pt
Short protocol
- r tPA 10 mg bolus + 90 mg in 90 min or
- SK 15lac in 60 min
Long protocol
-- SK- 5lac u in 20 min f/b 15lac u for 10 hr
-- rtPA -- 10 mgbolus f/b 90mg/hr for 9 hrs
Urokinase
High dose: 4,500 IU/kg/h for 12 h without heparin
Low dose: 2,000 IU/kg/h with heparin for 24 h
40. Embolization
Cerebral embolization CT normal/infarctwarf
& heparin – 72 hrs APTT lower therapeutic level
till the desired INR
Anticoagulantion delayed for at least 7 to 14 days -
ICH, extensive cerebral infarction OAC
41. Excessive Anticoagulation
Vit K 2.5 mg daily until the INR is acceptable
Fresh frozen plasma
Human recombinant factor VIIa, 15 to 19 g/kg
(INR >10.0 with bleeding)
42.
43. Paravalvular Regurgitation
Mild or moderate paravalvular leakage -
asymptomatic , may have only a mild hemolytic
anemia
- can be observed carefully with serial echo
Severe paravalvular leakage - usually have
symptoms of heart failure or severe anemia
- should be treated with surgical repair or
replacement of the valve