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VARIABLE-GAIN CONTROL
FOR RESPIRATORY SYSTEM
Presented By,
Joshna Jyothi R
M1 EEE
INTRODUCTION
• The world has been shocked by the COVID-19 disease.
• Acute respiratory failure (ARF) is the leading cause of death.
• 40 percent of critically ill COVID-19 patients developed acute respiratory
distress syndrome (ARDS) which requires invasive incubation and
ventilation .
• Mechanical ventilators are provided in hospitals.
OBJECTIVE
• To balance the tradeoff between the low-gain pressure and the high-gain
pressure control in the mechanical ventilation.
MECHANICAL VENTILATION
• It is used to assist the patients who have difficulty breathing on their own.
• It increases the pressure during an inspiration.
• The pressure is decreased during an expiration.
MECHANICAL VENTILATION
Schematic of a typical
breathing cycle during the
mechanical ventilation
MECHANICAL VENTILATION
• A good ventilator control design ensures that the target pressure is
accurately tracked by the ventilator.
• Patient-ventilator synchrony is important for the comfort of the patient.
• Asynchrony can lead to prolonged stay in the hospital and even associates
with higher mortality.
VARIABLE GAIN CONTROL
• High-gain pressure controller - To achieve a fast pressure buildup and
release during ventilation.
• Low-gain pressure controller - For keeping the amount of unwanted
oscillations in the patient flow signal small, because this can result in false
triggers.
• There is a tradeoff between applying a high-gain controller and a low-gain
controller.
• A variable-gain control strategy is proposed.
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
Fig. 1 Fig. 2
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• Fig. 1- Photograph of a respiratory system with a hose that connects to a patient.
• Fig. 2 - Schematic of a respiratory system showing the different pressures (red), flows
(blue), and resistances and compliance (black).
• Blower system - Pressurizes the ambient air in order to ventilate the patient.
• Hose - To connect the respiratory module to the patient.
• The flow Qout that leaves the system runs through the hose toward the patient.
• The patient exhales partly back through the blower and partly through a leak in the hose.
• The leak, with leak resistance Rleak, is used to refresh the air in the hose in order to
ensure that the patient does not inhale his/her own exhaled low-oxygen, CO2-rich air.
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• Using the conservation of flow, the output flow Qout, patient flow Qpat, and
leakage flow Qleak are related as follows:
Qpat = Qout − Qleak (1)
• Due to the hose resistance Rhose, the output pressure pout is not equal to airway
pressure paw at the patients mouth.
• The pressure inside the lungs [with lung compliance (elastance) Clung and
resistance Rlung] is defined as plung and cannot be measured in general.
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• Assuming linear resistances Rlung, Rleak, and Rhose, the pressure drop
across these resistances can be related to the flow through these
resistances
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• and where the lung pressure satisfies the following differential equation:
• Combining (2) and (3), the lung dynamics can be written as
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• Substituting and rewriting (2) in (1) result in the following relation for the airway
pressure:
• Substituting this expression for the airway pressure paw into the lung dynamics (4)
results in the following differential equation for the lung dynamics:
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• Given (2), (5), and (6), the patient and hose system can be written as a
linear state-space system with input pout, outputs [paw, Qpat] T , and state
plung.
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
(9)
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
Closed-loop control scheme with a linear controller C(s)
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• The unity feedforward in combination with the identified blower characteristic
ensures that the output pressure Pout can reasonably accurately track the target
pressure Pset feedforward alone.
• The feedback controller has to compensate for the pressure drop
along the hose.
• The pressure drop along the hose is difficult to predict due to several factors, so
feedback path needs to be employed.
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• The actual system can be modeled as a second-order low-pass filter.
• In the state-space format, (11) can be written as
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• System matrices
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• By coupling the patient hose system dynamics (7) and the blower dynamics (12), the
general state-space form of the plant P(s) (to be controlled by the feedback controller) can
be formulated as,
MATHEMATICAL MODEL OF A
RESPIRATORY SYSTEM
• with transfer function
PRESSURE CONTROLLER
• The goal of the pressure controller can
be achieved by formulating some
assumptions.
The rise time of a pressure set point
should be approximately 200 ms.
The pressure at the end of an
inspiration, plateau pressure, should
be within a pressure band of ±2 mbar.
The overshoot in the flow during an
expiration should have a typical value
of 2 L/min.
PERFORMANCE TRADEOFF USING
LINEAR CONTROL
Variable Value Unit
Rlung 5/1000
Clung 20
Rleak 60/1000
Rhose 4.5/1000
Wn
PERFORMANCE TRADEOFF USING
LINEAR CONTROL
• Paw/Pcontrol<1
• There will be a leakage flow through
the leakage hole in the hose, which
results in a pressure drop.
• To cope with such leakage-induced
disturbances, the following linear
integral feedback controller has been
designed:
PERFORMANCE TRADEOFF USING
LINEAR CONTROL
• Ki=0: The need for a feedback controller
in order to achieve the target pressure
accurately.
• Ki=0.4: The low-gain controller does
achieve the target pressure albeit slowly,
but it induces a flow response without
overshoot (favorable to avoid false
inspiration triggers).
• Ki=10: The high-gain controller achieves
the target pressure quickly, but it induces
an unwanted oscillation in the patient
flow, which may result in false patient
flow triggering.
VARIABLE-GAIN CONTROL SCHEME
• The variable-gain controller consists of a linear controller C(S) and a
variable-gain element and
VARIABLE-GAIN CONTROL SCHEME
Typical ventilation pattern with the desired intervals of high- and low-gain control.
VARIABLE-GAIN CONTROL SCHEME
• Switching law between low- and high-gain control ?
When the patient flow is small, the pressure drop along the hose is almost
constant, and the low-gain controller is favorable, since this minimizes the
oscillations in the flow response.
For large flows, however, during pressure buildup and pressure release, a
higher controller gain is desired in order to compensate for the pressure
drop along the hose quickly.
VARIABLE-GAIN CONTROL SCHEME
 Variable gain controller is proposed to switch the controller gain based on the patient
flow.
 ϕ(e, Qpat) = φ(Qpat)e
 φ(Qpat) should be designed to be large for large flows (high-gain) and small for small
flows (low gain).
• δ : switching length
• α : additional gain
RESULTS
RESULTS
• Clearly, the (linear) high-gain controller has a fast pressure buildup (and pressure
release) performance.
• The overshoot exceeds the flow trigger threshold of 2 L/min and would induce
the false patient triggers.
• The low-gain controller, has a stable flow response, but it is too slow in the
pressure buildup (and pressure release) in order to meet the desired rise-time
performance specification.
• The variable-gain controller uses the nonlinearity to differentiate between
low/high gains based on the patient flow information provided by the flow
sensors.
RESULTS
• If the patient flow is larger than δ = 6 L/min, the additional gain α applied
in order to compensate for the pressure drop along the hose and quickly
reach the desired pressure target, similarly as the high-gain controller.
• C˜ = C(s)(1 + α)
• However, once the patient lung becomes full, and the patient flow
becomes close to zero (and, hence, the pressure drop along the hose is
approximately constant), the low-gain controller is used in order to reach a
stable flow response without overshoot.
INFLUENCE OF SWITCHING LENGTH,
δ
INFLUENCE OF SWITCHING LENGTH
• A smaller δ value results in a small rise time, because the additional gain is active
for a longer period of time.
• However, it results in a larger overshoot.
• The variable-gain controller can balance this tradeoff in a more desirable manner,
by choosing, for example, δ ≈ 10 L/min, which results in a response with a good
rise time and also a small overshoot in the flow.
• The region in which overshoot and rise time are both small is quite large (e.g.,
any δ between 5 and 50 L/min would perform well), which means that the design
is robust with respect to the switching length δ
CONCLUSION
• Variable-gain control strategy for a mechanical ventilator is used in order to
balance the tradeoff between accurate and fast pressure buildup and a stable flow
response.
• The results confirm that indeed a variable-gain controller, which switches gains
on the basis of the magnitude of the patient-flow.
• As a benefit for the patient, trigger levels can be set to a small level, to allow for
best possible machine patient synchronization for the comfort of the patient,
while still achieving sufficiently fast pressure buildup that guarantees good
breathing support.
REFERENCES
• Hunnekens, B., Kamps, S. and Van De Wouw, N., 2018. Variable-gain
control for respiratory systems. IEEE Transactions on Control Systems
Technology, 28(1), pp.163-171.
• E. Akoumianaki et al., “Mechanical ventilation-induced reverse triggered
breaths: A frequently unrecognized form of neuromechanical coupling,”
Chest, vol. 143, no. 4, pp. 927–938, 2013.
• M. Borrello, “Modeling and control of systems for critical care
ventilation,” in Proc. Amer. Control Conf., Jun. 2005, p
THANK YOU

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Model Predictive Current Control with Adaptive-adjusting Timescales for PMSMs.pptx

  • 1. VARIABLE-GAIN CONTROL FOR RESPIRATORY SYSTEM Presented By, Joshna Jyothi R M1 EEE
  • 2. INTRODUCTION • The world has been shocked by the COVID-19 disease. • Acute respiratory failure (ARF) is the leading cause of death. • 40 percent of critically ill COVID-19 patients developed acute respiratory distress syndrome (ARDS) which requires invasive incubation and ventilation . • Mechanical ventilators are provided in hospitals.
  • 3. OBJECTIVE • To balance the tradeoff between the low-gain pressure and the high-gain pressure control in the mechanical ventilation.
  • 4. MECHANICAL VENTILATION • It is used to assist the patients who have difficulty breathing on their own. • It increases the pressure during an inspiration. • The pressure is decreased during an expiration.
  • 5. MECHANICAL VENTILATION Schematic of a typical breathing cycle during the mechanical ventilation
  • 6. MECHANICAL VENTILATION • A good ventilator control design ensures that the target pressure is accurately tracked by the ventilator. • Patient-ventilator synchrony is important for the comfort of the patient. • Asynchrony can lead to prolonged stay in the hospital and even associates with higher mortality.
  • 7. VARIABLE GAIN CONTROL • High-gain pressure controller - To achieve a fast pressure buildup and release during ventilation. • Low-gain pressure controller - For keeping the amount of unwanted oscillations in the patient flow signal small, because this can result in false triggers. • There is a tradeoff between applying a high-gain controller and a low-gain controller. • A variable-gain control strategy is proposed.
  • 8. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM Fig. 1 Fig. 2
  • 9. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • Fig. 1- Photograph of a respiratory system with a hose that connects to a patient. • Fig. 2 - Schematic of a respiratory system showing the different pressures (red), flows (blue), and resistances and compliance (black). • Blower system - Pressurizes the ambient air in order to ventilate the patient. • Hose - To connect the respiratory module to the patient. • The flow Qout that leaves the system runs through the hose toward the patient. • The patient exhales partly back through the blower and partly through a leak in the hose. • The leak, with leak resistance Rleak, is used to refresh the air in the hose in order to ensure that the patient does not inhale his/her own exhaled low-oxygen, CO2-rich air.
  • 10. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • Using the conservation of flow, the output flow Qout, patient flow Qpat, and leakage flow Qleak are related as follows: Qpat = Qout − Qleak (1) • Due to the hose resistance Rhose, the output pressure pout is not equal to airway pressure paw at the patients mouth. • The pressure inside the lungs [with lung compliance (elastance) Clung and resistance Rlung] is defined as plung and cannot be measured in general.
  • 11. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • Assuming linear resistances Rlung, Rleak, and Rhose, the pressure drop across these resistances can be related to the flow through these resistances
  • 12. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • and where the lung pressure satisfies the following differential equation: • Combining (2) and (3), the lung dynamics can be written as
  • 13. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • Substituting and rewriting (2) in (1) result in the following relation for the airway pressure: • Substituting this expression for the airway pressure paw into the lung dynamics (4) results in the following differential equation for the lung dynamics:
  • 14. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • Given (2), (5), and (6), the patient and hose system can be written as a linear state-space system with input pout, outputs [paw, Qpat] T , and state plung.
  • 15. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM (9)
  • 16. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM Closed-loop control scheme with a linear controller C(s)
  • 17. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • The unity feedforward in combination with the identified blower characteristic ensures that the output pressure Pout can reasonably accurately track the target pressure Pset feedforward alone. • The feedback controller has to compensate for the pressure drop along the hose. • The pressure drop along the hose is difficult to predict due to several factors, so feedback path needs to be employed.
  • 18. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • The actual system can be modeled as a second-order low-pass filter. • In the state-space format, (11) can be written as
  • 19. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • System matrices
  • 20. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • By coupling the patient hose system dynamics (7) and the blower dynamics (12), the general state-space form of the plant P(s) (to be controlled by the feedback controller) can be formulated as,
  • 21. MATHEMATICAL MODEL OF A RESPIRATORY SYSTEM • with transfer function
  • 22. PRESSURE CONTROLLER • The goal of the pressure controller can be achieved by formulating some assumptions. The rise time of a pressure set point should be approximately 200 ms. The pressure at the end of an inspiration, plateau pressure, should be within a pressure band of ±2 mbar. The overshoot in the flow during an expiration should have a typical value of 2 L/min.
  • 23. PERFORMANCE TRADEOFF USING LINEAR CONTROL Variable Value Unit Rlung 5/1000 Clung 20 Rleak 60/1000 Rhose 4.5/1000 Wn
  • 24. PERFORMANCE TRADEOFF USING LINEAR CONTROL • Paw/Pcontrol<1 • There will be a leakage flow through the leakage hole in the hose, which results in a pressure drop. • To cope with such leakage-induced disturbances, the following linear integral feedback controller has been designed:
  • 25. PERFORMANCE TRADEOFF USING LINEAR CONTROL • Ki=0: The need for a feedback controller in order to achieve the target pressure accurately. • Ki=0.4: The low-gain controller does achieve the target pressure albeit slowly, but it induces a flow response without overshoot (favorable to avoid false inspiration triggers). • Ki=10: The high-gain controller achieves the target pressure quickly, but it induces an unwanted oscillation in the patient flow, which may result in false patient flow triggering.
  • 26. VARIABLE-GAIN CONTROL SCHEME • The variable-gain controller consists of a linear controller C(S) and a variable-gain element and
  • 27. VARIABLE-GAIN CONTROL SCHEME Typical ventilation pattern with the desired intervals of high- and low-gain control.
  • 28. VARIABLE-GAIN CONTROL SCHEME • Switching law between low- and high-gain control ? When the patient flow is small, the pressure drop along the hose is almost constant, and the low-gain controller is favorable, since this minimizes the oscillations in the flow response. For large flows, however, during pressure buildup and pressure release, a higher controller gain is desired in order to compensate for the pressure drop along the hose quickly.
  • 29. VARIABLE-GAIN CONTROL SCHEME  Variable gain controller is proposed to switch the controller gain based on the patient flow.  ϕ(e, Qpat) = φ(Qpat)e  φ(Qpat) should be designed to be large for large flows (high-gain) and small for small flows (low gain). • δ : switching length • α : additional gain
  • 31. RESULTS • Clearly, the (linear) high-gain controller has a fast pressure buildup (and pressure release) performance. • The overshoot exceeds the flow trigger threshold of 2 L/min and would induce the false patient triggers. • The low-gain controller, has a stable flow response, but it is too slow in the pressure buildup (and pressure release) in order to meet the desired rise-time performance specification. • The variable-gain controller uses the nonlinearity to differentiate between low/high gains based on the patient flow information provided by the flow sensors.
  • 32. RESULTS • If the patient flow is larger than δ = 6 L/min, the additional gain α applied in order to compensate for the pressure drop along the hose and quickly reach the desired pressure target, similarly as the high-gain controller. • C˜ = C(s)(1 + α) • However, once the patient lung becomes full, and the patient flow becomes close to zero (and, hence, the pressure drop along the hose is approximately constant), the low-gain controller is used in order to reach a stable flow response without overshoot.
  • 34. INFLUENCE OF SWITCHING LENGTH • A smaller δ value results in a small rise time, because the additional gain is active for a longer period of time. • However, it results in a larger overshoot. • The variable-gain controller can balance this tradeoff in a more desirable manner, by choosing, for example, δ ≈ 10 L/min, which results in a response with a good rise time and also a small overshoot in the flow. • The region in which overshoot and rise time are both small is quite large (e.g., any δ between 5 and 50 L/min would perform well), which means that the design is robust with respect to the switching length δ
  • 35. CONCLUSION • Variable-gain control strategy for a mechanical ventilator is used in order to balance the tradeoff between accurate and fast pressure buildup and a stable flow response. • The results confirm that indeed a variable-gain controller, which switches gains on the basis of the magnitude of the patient-flow. • As a benefit for the patient, trigger levels can be set to a small level, to allow for best possible machine patient synchronization for the comfort of the patient, while still achieving sufficiently fast pressure buildup that guarantees good breathing support.
  • 36. REFERENCES • Hunnekens, B., Kamps, S. and Van De Wouw, N., 2018. Variable-gain control for respiratory systems. IEEE Transactions on Control Systems Technology, 28(1), pp.163-171. • E. Akoumianaki et al., “Mechanical ventilation-induced reverse triggered breaths: A frequently unrecognized form of neuromechanical coupling,” Chest, vol. 143, no. 4, pp. 927–938, 2013. • M. Borrello, “Modeling and control of systems for critical care ventilation,” in Proc. Amer. Control Conf., Jun. 2005, p