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Fetal haemoglobin induction in SCD
Reactivation of fetal hemoglobin (HbF) expression is an important
therapeutic option in patients with hemoglobin disorders. In sickle cell
disease (SCD), an increase in HbF inhibits the polymerization of sickle
hemoglobin and the resulting pathophysiology.
Pharmacological induction of Hbf
• DNA methyltransferase (DNMT) inhibitors
• Histone deacetylase inhibitors
• Metformin
• Hydroxyurea
Hydroxyurea
Mechanism of action of hydroxyurea
Globin gene regulation through miRNA
fetal Hb Presentation (2).pptx
fetal Hb Presentation (2).pptx

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fetal Hb Presentation (2).pptx