Good Stuff Happens in 1:1 Meetings: Why you need them and how to do them well
fetal Hb Presentation (2).pptx
1. Fetal haemoglobin induction in SCD
Reactivation of fetal hemoglobin (HbF) expression is an important
therapeutic option in patients with hemoglobin disorders. In sickle cell
disease (SCD), an increase in HbF inhibits the polymerization of sickle
hemoglobin and the resulting pathophysiology.
2. Pharmacological induction of Hbf
• DNA methyltransferase (DNMT) inhibitors
• Histone deacetylase inhibitors
• Metformin
• Hydroxyurea