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FoodON Use Cases: Food Allergy
Emma Griffiths, PhD
Brinkman Lab
Department of Molecular Biology and Biochemistry
Simon Fra...
Definition of a Food Allergy
• Food allergies: body’s immune response to food antigen
• Allergy (IgE-mediated) vs intolera...
• Food intolerance
The Problem: Lack of a Standardized Food Vocabulary
Impacts Allergy Risk Assessment and Research
3
Synonyms
• Arachide
• Cacahouète
• Goober peas
• Kernels
• Mandelonas
• Nut meats
• Valencias
Possible Food Sources
• Marz...
1. Identify hazards
(synonyms/sources)
2. Identify control points (handling &
storage, HACCP)
3. Standardized labeling
4. ...
The Mission of The CHILD Study
To determine the causal factors of asthma and allergy
during childhood development
http://w...
Infant Food Types
• Breast milk
• Formula
• Vitamins
Parenting Guidelines
• Breastfeeding Practices
• Introduction of Adul...
Who Should Shape the Food Allergy Domain?
• Food Advocates
• Clinicians
• Allergy Researchers
8
…And The FoodON
Consortium Founding
Members!
Acknowledgements
SFU
Fiona Brinkman
Geoff Winsor
Gemma Hoad
Thea Van Rossum
B...
Activity – Identify the Common Allergens
• Fresh large eggs
• Frozen whole-kernel
corn
• Low fat 1% milk
• Fresh green pep...
• Fresh large eggs
• Frozen whole-kernel
corn
• Low fat 1% milk
• Fresh green peppers,
diced
• Fresh onions, diced
• Fresh...
• Fresh large eggs
• Frozen whole-kernel
corn
• Low fat 1% milk
• Fresh green peppers,
diced
• Fresh onions, diced
• Fresh...
• Fresh large eggs
• Frozen whole-kernel
corn
• Low fat 1% milk
• Fresh green peppers,
diced
• Fresh onions, diced
• Fresh...
• Fresh large eggs
• Frozen whole-kernel
corn
• Low fat 1% milk
• Fresh green peppers,
diced
• Fresh onions, diced
• Fresh...
• Fresh large eggs
• Frozen whole-kernel
corn
• Low fat 1% milk
• Fresh green peppers,
diced
• Fresh onions, diced
• Fresh...
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Emma Food on workshop allergy_eg

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FoodON Use Cases: Food Allergy

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Emma Food on workshop allergy_eg

  1. 1. FoodON Use Cases: Food Allergy Emma Griffiths, PhD Brinkman Lab Department of Molecular Biology and Biochemistry Simon Fraser University International Conference on Biological Ontologies, Corvallis, OR Aug 4 2016 1
  2. 2. Definition of a Food Allergy • Food allergies: body’s immune response to food antigen • Allergy (IgE-mediated) vs intolerance (non-IgE response) Issues: • Describing Common & Hidden food allergens • Cross-contact concerns 2
  3. 3. • Food intolerance The Problem: Lack of a Standardized Food Vocabulary Impacts Allergy Risk Assessment and Research 3
  4. 4. Synonyms • Arachide • Cacahouète • Goober peas • Kernels • Mandelonas • Nut meats • Valencias Possible Food Sources • Marzipan • Asian cuisine • Baked goods • Candies • Cereals and granola • Chili • Chipotle sauce • Salad dressings • Snack foods • Vegetarian meat substitutes Non-Food Sources • Pest bait • Cosmetics • Craft materials • Medications & vitamins • Pet foods • Sunscreen • Stuffing in children’s toys Peanuts: An Ontology Case Study [NCBITaxon] Taxonomy: Arachis hypogaea [DOID] Peanut Allergy Definition: A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms. 4
  5. 5. 1. Identify hazards (synonyms/sources) 2. Identify control points (handling & storage, HACCP) 3. Standardized labeling 4. Comparing data across studies 5. Implementing results in policy Why Do We Need A Food Ontology for Food Allergy? 5
  6. 6. The Mission of The CHILD Study To determine the causal factors of asthma and allergy during childhood development http://www.canadianchildstudy.ca/ 6
  7. 7. Infant Food Types • Breast milk • Formula • Vitamins Parenting Guidelines • Breastfeeding Practices • Introduction of Adult Food Processing/Preservation • Pasteurization Storage • Contact Concerns • Chemical Exposure e.g. phthalates Biochemical Factors of Food & Allergy • Immune Response • Diet • Microbiomes • Genetics & Predisposition How FOODON Would be Useful for CHILD and Allergy Research 1. Compare food descriptors across child cohorts 2. Correlate food facets with biological causes 3. Create guidelines for parents 7
  8. 8. Who Should Shape the Food Allergy Domain? • Food Advocates • Clinicians • Allergy Researchers 8
  9. 9. …And The FoodON Consortium Founding Members! Acknowledgements SFU Fiona Brinkman Geoff Winsor Gemma Hoad Thea Van Rossum BC Centre for Disease Control Will Hsiao Damion Dooley CHILD Investigators Malcolm Sears Diana Lefebvre David Dai PJ Subbarao Tim Takaro Stuart Turvey Anita Kozyrskyj Diana Royce Meghan Azad Dean Beafus Jeff Brook Scott Tebbutt Denise Daley Michael Kobor Judah Denburg …. 9Email: ega12@sfu.ca
  10. 10. Activity – Identify the Common Allergens • Fresh large eggs • Frozen whole-kernel corn • Low fat 1% milk • Fresh green peppers, diced • Fresh onions, diced • Fresh tomatoes, diced • Yellow mustard • Hot pepper sauce • Salt • Reduced fat cheddar cheese • Flour tortillas Breakfast Burrito Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis 10
  11. 11. • Fresh large eggs • Frozen whole-kernel corn • Low fat 1% milk • Fresh green peppers, diced • Fresh onions, diced • Fresh tomatoes, diced • Yellow mustard • Hot pepper sauce • Salt • Reduced fat cheddar cheese • Flour tortillas Breakfast Burrito Activity – Identify the Common Allergens Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis 11
  12. 12. • Fresh large eggs • Frozen whole-kernel corn • Low fat 1% milk • Fresh green peppers, diced • Fresh onions, diced • Fresh tomatoes, diced • Yellow mustard • Hot pepper sauce • Salt • Reduced fat cheddar cheese • Flour tortillas Breakfast Burrito Activity – Identify the Possible Hidden Allergens Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis 12
  13. 13. • Fresh large eggs • Frozen whole-kernel corn • Low fat 1% milk • Fresh green peppers, diced • Fresh onions, diced • Fresh tomatoes, diced • Yellow mustard • Hot pepper sauce • Salt • Reduced fat cheddar cheese • Flour tortillas Breakfast Burrito Activity – Identify the Possible Hidden Allergens Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis 13
  14. 14. • Fresh large eggs • Frozen whole-kernel corn • Low fat 1% milk • Fresh green peppers, diced • Fresh onions, diced • Fresh tomatoes, diced • Yellow mustard • Hot pepper sauce • Salt • Reduced fat cheddar cheese • Flour tortillas Breakfast Burrito Activity – Identify the Cross Contact Concerns Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis 14
  15. 15. • Fresh large eggs • Frozen whole-kernel corn • Low fat 1% milk • Fresh green peppers, diced • Fresh onions, diced • Fresh tomatoes, diced • Yellow mustard • Hot pepper sauce • Salt • Reduced fat cheddar cheese • Flour tortillas Breakfast Burrito Food Safety for Child Nutrition Programs: Department of Nutrition, University of California, Davis Activity – Identify the Cross Contact Concerns 15

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