2. INTRODUCTION:
Domain : Bacteria;
Phylum : Proteobacteria;
Class : Gammaproteobacteria;
Order : Enterobacteriales;
Family : Enterobactriaceae;
Genus: Klepsiella;
Species: pneumoniae;
3. Klebsiella pneumoniae also called
friedlander’s bacillus, was first described
1882 by german microbiologiest and
pathologiest carl friedlander.
The disease is usually seen only in
patients with underlying medical
problems such as alcoholism or chronic.
5. MORPHOLOGY
Gram Negative, small (0.5 0.8 to 1 2um
)coccobacilli.
Does not form spores is fixed capable of forming
capsule.
Arranged singly, in pairs and clusters, easily
stained with aniline dyes.
Bacteria Klebsiella is know for its polysaccharite
capsule that surrounds the entire organism know.
10. HiCrome Klebsiella selective agar base
Composition Gms/Litre
Peptone, special 12.000
Yeast extract 7.000
Sodium Chloride 5.000
Bile salt mixture 1.500
Sodium lauryl sulphate (SLS) 0.100
Chromogenic mixture 0.200
Agar 15.000
pH at 25 c 7.1
11. EPIDEMIOLOGY
Klebsiella are ubiquitous in nature in human,
they may colonize the skin, pharynx,
gastrointestinal tract.
They may also colonize sterile wounds and urine.
Carriage rates vary with different studies.
Klebsiella may be regarded as normal flora in
may parts of the colon and intestinal tract and in
billary tract.
12. Infection with Klebsiella organisms occurs in
thelungs, where they cause destructive change.
Necrosis, inflammation and hemorrhage occur
with in lung tissue sometimes producing thick.
Blood, mucoid sputum described currant jelly
sputum.
Klebsiellae have also been incrimination in
nasocominal infection. Commonsites the urinary
tract, lowerrespiratory tract, billary tact, and
surgical wounds sites.
14. The spectrum of clinical syndromes includes
pnemonia, bacteremia, thrombophlebitis, urinary
tract infection, diarrhea, upper respiratory tract
infection, wounds infection, meningitis.
UNITED STATES:
In some parts of the world K.pneumoniae is an
important cause of community acquired
pneumonia in elderly persons.
15. Studies conducted in malaysia and japan
estimate the incidence rate elderly persons 15to
40% which equal, not greater than haemophillus
influenzae.
However in the united states figurea are different
persons alcoholism main population risk they
constitute 66% of people affected by this disease.
Mortality rates are as high 50% and a approch
100% persons alcoholism and bacteremia.
16. Outbreak of neonatal septicemia occur worldwide
distribution and is usually observed areas
Europe, Southern Asia, central africa, latin
america,
Mortality/Morbidity:
K.pneumonia is a necrotizing process with
predillection for debillitated people,
It has high mortality approximetely 50% evan
microbial therapy.
17. The mortality rate approches 100% persons with
alcoholism and bacteremia.
Age:
Community acquired K.pneumonia is a diseae of
debilitated middle aged and older men with
alcoholism.
Nosocomial infection may affect aduld of children
and they occur more frequently in premature
infants, patients in neonatal intensive cre units,
hospitalized individual who are
immunocompromised.
