El 12 de mayo de 2017 celebramos en la Fundación Ramó Areces una jornada con IS Global y Unitaid sobre enfermedades transmitidas por vectores, como la malaria, entre otras.

1. Progress on a Randomised Controlled Trial for
evaluation of Screening + Eave Tubes
Matt Thomas
Penn State University

2. Eaves are the main entry point for anophelines

5. 200xPatent:
WO2009048324A1

7. - Powdered insecticide on netting can kill resistant
mosquitoes (even using the same class of
insecticide to which they are nominally resistant) =
resistance breaking.
- Around 60% mortality of mosquitoes in overnight
screen house studies.
- Addition of eave tubes to screening improves
overall control (lethal effect of eave tubes prevents
deflection and increases mass action effect).
- Screening + Eave Tubes (SET) improves control
relative to LLINs alone.

8. Testing eave tubes in ‘Model Village’

9. Mar May Jul Sep Nov Jan
02004006008001000
(a) Average numbers sampled using larval dippers
Larvae
No intervention
LLINs only
Eave tubes
Mar
050100150
(b
Indoorhostseekingadultfemales
Mosquito numbers in the ‘Model Village’
Average number of larvae collected from larval
habitats in the 6 sampling zones

10. INSTITUT PIERRE RICHET
Funded by the:

11. Two armed randomized controlled trial (2016 – 2018):
• 20 villages will receive new LLINs + eave tubes and
house screening.
• 20 villages will only receive new LLINs.
Outcomes:
• Epidemiology
• Entomology
• Physical environment
• Social science
• Economic analysis.
takeholder Workshop for BMGF-funded project
n of Eave Tubes from Concept to Implementation”
Amsterdam, June 9-10, 2016
tion): Location (Meeting):
tel Royal Tropical Institute (KIT)
Mauritskade 63
1092 AD Amsterdam
The Netherlands
mtropenhotel.com/ Congress room: ‘Maurits zaal’
Day 1 (Thursday June 9)
Activity
Welcome and Introductions
Overview of Eave Tube Technology
Break
Background efficacy data
Data from pilot implementation
Lunch
Overview of current Gates-funded Project
Overview of RCT
Epidemiology
Entomology
Break
Social science
Production & Installation
Economics
Summary of progress (recap) and open discussions

12. Study region in central Cote d’Ivoire:

13. 0 10 20 30 km
Bouake
45 50 55 60 65 70 75 80 85 90 95 % RDT+
90 150 250 364 Number of houses

19. 0
20
40
60
80
100
PercentMortality
Percentage mortality of pyrethroid susceptible and resistant
Anopheles gambiae on PermaNet 2.0 LLIN in WHO cone bioassays

20. Percentage mortality of pyrethroid resistant Anopheles gambiae on
Eave Tube inserts treated with 10% Beta Cyfluthrin (Tempo 10 WP)
0
20
40
60
80
100
PercentMortality

21. • Installations completed in 20 villages (3022 houses, 31250
tubes, average 77% consent).
• Treatment of inserts and distribution of LLINs completed.
• Monitoring underway.
• Various additional entomological experiments to help
interpret RCT (including household level trial).
takeholder Workshop for BMGF-funded project
n of Eave Tubes from Concept to Implementation”
Amsterdam, June 9-10, 2016
tion): Location (Meeting):
tel Royal Tropical Institute (KIT)
Mauritskade 63
1092 AD Amsterdam
The Netherlands
mtropenhotel.com/ Congress room: ‘Maurits zaal’
Day 1 (Thursday June 9)
Activity
Welcome and Introductions
Overview of Eave Tube Technology
Break
Background efficacy data
Data from pilot implementation
Lunch
Overview of current Gates-funded Project
Overview of RCT
Epidemiology
Entomology
Break
Social science
Production & Installation
Economics

22. Mean (+/- SE) number of An. gambiae collected from
experimental huts containing eave tubes with treated vs
untreated inserts over 8 nights
Numbercaughtpernight

23. Mean (+/- SE) proportional mortality of An. gambiae 24h after
capture (8 nights collection from experimental huts containing
eave tubes with treated vs untreated inserts)
Proportionofdeadmosquitoesafter24h