Oncolytic viruses（OVs）are viral strains that can infect and kill malignant cells without harming normal cells, while simultaneously stimulate the immune system and creating system antitumor immunity. Oncolytic viruses have become one of the aglare immunotherapies that have been extensively studied and developed. Creative Biolabs is a world-renowned service provider for immunotherapy. Taking advantage of the OncoVirapy™ platform, Creative Biolabs provides a comprehensive overview on the basic biology that support OVs as cancer therapeutic agents, including properties of inherent and engineered oncolytic viruses, mechanisms of viral targeting cancer cells, mechanisms of action of viruses killing cancer cells (induction of local and systemic anti-tumor immunity). Based on this basic knowledge review, we hope you can have a comprehensive understanding of OVs and quickly capture one of the frontiers of immunotherapy research.

1. Address: 45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994 Fax: 1-631-207-8356
Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/

2. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
2Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields.
Introduction
The development of cancer treatment
Traditional remedy
• Surgery
• Radiation
• Chemotherapy
Targeted therapy
• Small molecule targeting drug
• Monoclonal antibody drugs
Immunotherapy
•Activate the body's immune
system

3. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356Introduction
Immunotherapy
Adoptive cell
therapy
Immune
checkpoints
blockade
Cancer
Vaccines
Cytokine
therapy
Oncolytic
virotherapy
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 3

4. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356Introduction
Oncolytic viruses (OVs) are viral strains that can infect and kill malignant cells without harming normal cells,
while simultaneously stimulating the immune system and creating antitumor immunity.
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 4

5. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Conscious of potenti
al application as a
cancer therapy
Interest in oncolytic
viruses waned due
to side effects
Genetic engineering
lead to viral therapy
from laboratory to
bedside
The first oncolytic
virus approved by
the FDA
Brief history of oncolytic virus
development
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 5

6. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Tumor tropism Tumor cell lysis
Anti-tumor immune response
• Mechanisms of Tumor Tropism
• Mechanisms of oncolytic viruses destroying tumor cells
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 6
How dose oncolytic virus work？

7. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
• Aberrant receptors
• Abnormal signaling pathways
• Hypoxic environment
Mechanisms of Tumor Tropism
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 7
How dose oncolytic virus work？

8. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Mechanisms of Tumor Tropism --Abnormal cell receptors
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 8
How dose oncolytic virus work？

9. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Mechanisms of Tumor Tropism --Aberrant signaling pathways
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 9
How dose oncolytic virus work？

10. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Mechanisms of oncolytic virus destroying tumor cells
• Tumor cell lysis
• Inducing system immune response
• Anti-viral immune response
enhancing system immune
response
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 10
Mechanisms
How dose oncolytic virus work？

11. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Mechanisms of action of viruses destroying tumor cells
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 11
How dose oncolytic virus work？

12. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Inherent
Newcastle Disease Virus,
Vesicular Stomatitis Virus,
Parvovirus,
Coxsackievirus,
Reovirus.
Engineered
Herpes Simplex Virus,
Adenovirus, Poliovirus,
Vaccinia Virus, Influenza Virus,
Measles Virus,
Vescilar Stomatitis Virus,
Adeno-Associated Virus.
Inherent and engineered oncolytic viruses
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 12
• Selectively target tumor cells
• Decrease pathogenicity to normal cells
• Decrease the antiviral immune response
• Increase the antitumor immune response.
• Inherent oncotropic

13. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356Prospection
Although the mechanisms of action of oncolytic
viruses are still incompletely understood, it appears
that the therapeutic efficacy of oncolytic viruses is
determined by a combination of direct tumor cell lysis
and indirect activation of anti-tumor immune
responses. However, further investigation of the
underlying mechanisms is the driving force behind
oncolytic therapy. Oncolytic therapy has made great
strides in recent years. By embracing immune
manipulation as a route to enhanced viral efficacy,
oncolytic virotherapy is bound to rapidly expand in the
near future.
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 13

14. Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
Tel: 1-631-381-2994
Fax: 1-631-207-8356OncoVirapy™ Platform
Oncolytic virus therapy development services
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. 14

15. Address: 45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994 Fax: 1-631-207-8356
Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/