ISS National Laboratory Pathfinder Missions

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American Astronautical Society

Jeanne L. Becker, PhD, 2010 American Astronautical Society Goddard Memorial Symposium

Technology

ISS National Laboratory Pathfinder Missions Therapeutics for Infectious Disease Jeanne L. Becker, Ph.D.

Overview: Therapeutics for Infectious Disease ,[object Object],[object Object],[object Object],[object Object],[object Object]

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An experiment conducted on the space shuttle demonstrated that Salmonella grown in space becomes more virulent, as compared to the same bacteria grown here on earth

[object Object],[object Object],[object Object],[object Object],If the cause of the increased virulence could be determined, can this knowledge be used to create a vaccine?

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Flight Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Taking advantage of the changes in biological processes that occur in microgravity to create new treatments for disease

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How can using space change drug development on earth? ,[object Object],[object Object],[object Object],[object Object]

Using Space to Develop Products for Earth ,[object Object],[object Object],+ = Virulence Gene Deletion Flight testing IND

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The 2018 Open Session of the EuFMD Standing Technical Committee was held in Borgo Egnazia - Italy, 29-31 October 2018 . The session theme was on global vaccine security The European Commission for the Control of Foot-and-Mouth Disease (EuFMD), one of FAO’s oldest Commissions, came into being on the 12th June 1954, with the pledge of the sixth founding member state to the principles of a coordinated and common action against Foot-and-mouth Disease.

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Surveillance systems are an essential component of biosecurity. Design of biosecurity surveillance systems may include designs of grids of static traps, plans for field sampling, or deployment of potentially "game-changing" mobile trap technology. The aim of these systems is to achieve defined detection objectives, (e.g. early detection, supporting area-freedom status) at minimum cost. This project will develop and apply statistically-based surveillance systems that account for organism biology, trap behaviour and landscape characteristics.

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Ships arriving in Australia may have visited multiple ports along the way. These complex pathways present opportunities for pest species, such as the Asian Gypsy Moth, to arrive into Australia from indirect routes. Understanding those pathways that link Australia directly or indirectly to countries in which a pest or disease occurs is necessary to identify arriving ships with the highest likelihood of carrying hitchhiker species. This project proposes to address three important questions: 1. What general shipping pathways pose the greatest risk? 2. How to make decisions regarding what ships to search? 3. How much inspection to conduct?

Rethinking biosecurity inspections using statistical modelling and simulation...

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Session 3: Application of next-generation sequencing to routine plant virus d...

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Session 7: Probiotic diets to increase Queensland fruit fly male performance ...

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Session 6: Design and Evaluation of Targeted Biosecurity Surveillance Systems

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Here we update on fundamental systematics research and the development of new potential molecular markers to improve on current diagnostic tools. We also link these molecular tools with physical specimens, documenting the range of morphological variation so as to greatly improve on available resources used to diagnose fruit flies in the field as part of surveillance programmes or at border interceptions.

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The Global Micorbial Identifier (GMI) initiative - and its working groups

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Session 5: Decision making for eradication and quarantine zones

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Session 7: Identification of Xanthomonas species causing bacterial leaf spot ...

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The diagnosis of viral pathogens is a crucial component of plant biosecurity surveillance and preventing the introduction of exotic plant viruses and viroids at the border. Existing quarantine procedures can be time-consuming and require detailed knowledge of potential infecting viral pathogens. Currently, imported plants can spend as long as two years in quarantine, with associated costs. To simplify the post-entry quarantine process researchers have developed a plant diagnostic toolkit for plant viruses and viroids. The toolkit takes advantage of the natural antiviral system of plants, using small RNA next generation sequencing (sRNA-seq) technology to detect nearly all known viruses and viroids in a single test. The new test, and associated toolkit, will reduce the time imported plant material spends in Australia’s quarantine system while improving accuracy of detection in a single sRNA-seq experiment.

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Session 1: Plant pest impacts - a common set of metrics

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Smart-trap design and deployment strategies

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Session 2: Genome-Informed Diagnostics - In-field Detection of Bacterial Plan...

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Developing tools for in-field surveillance of pathogens

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Session 1: Natural dispersal as a biosecurity risk - are we prepared?

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