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1. GROUP NO 1 . IMMUNOGLOBULIN G(Ig
G)
Objectives
1. Introduction
2. Sub-types/sub-classes
3. Properties
4. Functions/roles of Ig G
5. Deficit

2. Introduction
 Immunoglobulin G (Ig G) Is the most common and abundant antibody. Blood
plasma consists of 75-80% of Ig G antibodies
 It has longest life span of about 23 days, It can cross the placental barrier and
provide passive immunity to a developing fetus.
 Ig G antibodies remember the pathogens that have previously entered the body
and caused an infection

3. PROPERTIES
 It is the most versatile Ig and can carry all function of Ig molecules
 It is the major Ig in serum
 It is the only Ig that crosses placenta
 It is also found in extra-vascular space
 It fixes complement although not all sub classes do this well
 It binds to cells and is a good poisoning (substance that enhance phagocytosis)

4. SUB-CLASSES/TYPES
Ig G Is the combination of four different types which are IgG1, IgG2, IgG3 and IgG4
IgG1 Is the most abundant IgG sub-class in human sera, it mediates antibody
responses against viral pathogen
IgG2 it protect against protein antigens but responsible for anti carbohydrate IgG
responses against bacterial capsular polysaccharides.
 IgG3 it is known to promote inflammation as is associated with enhanced control
or protection against a range of intracellular bacteria, parasite and viruses.
 IgG4 It is believed to constitute a veritable antigen ‘garbage disposal’ system
which can attenuate inflammation.

6. FUNCTIONS/ ROLES
 It binds and neutralizes toxin
 It protect the body from infection
 It play an important role in antibody dependent cell mediated cytotoxicity
 Involved in regulation of allergic reaction

7. DEFICIT
 IgG deficiency is a health problem in which a body does not make enough
immunoglobulin G and predispose person to get infection
 IgG DEFICIENCY may be caused by aging, malnutrition, chemotherapy
medicines and long term corticosteroids

8. DEFICIT SYMPTOMS
 Ear infections
 Pneumonia
 Sore throat
 Bronchitis
 Gastrointestinal infection

9. GROUP MEMBERS
 Egon Moshi
 Asmaa Aboubakary
 Neema Augustine
 Lilian Emmanuel
 Salma Abdalah
 Sitta Malenya
 Michael Daudi
 Agape Piniel