Monoclonal antibodies are artificially produced identical antibodies that are derived from a single parent cell. Some key historical milestones included the 1973 concept of hybridoma technology by Jerrold Schwaber, the 1975 development of hybridomas by Kohler and Milstein to produce large amounts of monoclonal antibodies, and their receipt of the 1984 Nobel Prize in Medicine. Monoclonal antibodies provide passive immunity for immune deficient patients and were first approved for use in humans in 1986.

1. Monoclonal
Antibodies (mAb)
Bharati Vidyapeeth (Deemed To be University)
POONA COLLEGE OF PHARMACY
Pune 411038.
DR. VIVIDHA DHAPTE-PAWAR
1

2. 1973 : Concept of ‘Hybridoma’ by Jerrold Schwaber
1975 : Hybridomas developed by George Kohler and
Cesar Milstein to obtain large amounts of a mAb
1984 : They received the Nobel Prize for Medicine
1988 : Greg Winter humanized mAb
1986 : 1st mAb in market (Muromonab-CD3)
2003 : 1st Fully human mAb in market (Adalimumab)
HISTORICAL
MILESTONES

3. mAb
Identical Ab as they are produced by
single type of immune cell, all clones
of a single parent cell
Essential in Immune deficient patients
E.g. Cancer, HIV patients, anti-snake
venom
ARTIFICIALLY ACQUIRED,
PASSIVE IMMUNITY
Produced from
plasma Cells/ WBCs

6. Source: Ghosh et al. Indian Journal of Clinical Medicine 2013:4 9–21.