Monoclonal antibody # Definition # A general representation of the method used to produce monoclonal antibodies #Applications​ # Monoclonal antibodies for cancer. #MAbs​ approved by the FDA for cancer include: # Factor affecting monoclonal antibody immunogenicity #Monoclonal​ Antibodies : 4 Types # Monoclonal Antibodies : 4 Types images

1. Monoclonal antibody
• Presented By:
• Khushbu’s Microbiology

2. Monoclonal antibody
• mAb or moAb : is an antibody made
by cloning a unique white blood cell.
• All subsequent antibodies derived this
way trace back to a unique parent cell.

3. A general representation of the method
used to produce monoclonal antibodies

4. Applications
Diagnostic tests
Analytic & chemical uses
Therapeutic use
Cancer treatment

5. Monoclonal antibodies for cancer.
• ADEPT, antibody
directed enzyme
prodrug therapy;
• ADCC: antibody
dependent cell-
mediated cytotoxicity;
CDC: complement-
dependent cytotoxicity,
• MAb: monoclonal
antibody; scFv, single-
chain Fv fragment.

6. MAbs approved by the FDA for cancer include:
• Alemtuzumab
• Bevacizumab
• Cetuximab
• Gemtuzuma
ozogamicinb
• Ipilimumab
• Ofatumumab
• Panitumumab
• Pembrolizumab
• Ranibizumab
• Rituximab
• Trastuzumab

8. Monoclonal Antibodies : 4 Types
1. Murine :purely obtained from mice can cause
human anti mouse antibodies (HAMA) to name
its ending “momab” (ibritumomab).
2. Chimeric: combined Fc human antibodies and
Fab monoclonal antibodies mice, the sling
name “ximab” (rituximab).
3. Humanized: only a small fraction of Fab mouse
antibodies combine with human antibodies (95-
98%) the sling name is “zumab” (trastuzumab).
4. Fully human, the whole human antibody, the
sling names “mumab” (adalimumab).

9. Monoclonal Antibodies : 4 Types