biosynthesis of nucleotides

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NUCLEOTIDEBIOSYNTHESIS
Bio-synthesis of Purines &Pyrimidines

2. “The formation of DNA's structure by Watson and Crick may turn out to be the
greatest developments in the field of molecular genetics in recent years”
Linus Pauling, 1953
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3. Learning objectives:
How nucleotides are synthesized in the cells?
Understand the TwoPathwaysof nucleotide biosynthesis
 (1). De-novo synthesis and (2). SalvagePathways
De-novo synthesis of purines
 SynthesisofIMP(precursor of adenine and guanine)
 Synthesis of Adenineand Guaninefrom IMP
De-novo synthesis of pyrimidines
 Synthesis of Uracil
 Synthesis of Cytosine
 Synthesis of deoxy nucleotides
 Synthesis of Thymine Salvage
pathwaysof Purines and Pyrimidines
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31. NUCLEOTIDEBIOSYNTHESIS
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novo-salvage-purine-pyrimidine-nucleotides-cells/
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