Gpat Preparation

1. PREPARING FOR GPAT
Dr. Manoj R. Kumbhare
Professor
S.M.B.T. College of
Pharmacy, Dhamangaon
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2. Objectives
• To create awareness of GPAT
examination among the
pharmacy students.
• To motivate students to pursue
their higher studies
2

3. GPAT
• Graduate Pharmacy Aptitude Test
• Organized by AICTE
• Conducted online test every year in the
month of February
• No, of Questions: 125
• Pattern Multiple choice questions
3

4. GPAT Exam Pattern
• Candidates have to appear for a single test.
The total time duration of the exam will be
3 hours.
• Candidates are required to appear for CBT at
their allotted examination center only.
• Each correct answer will lead to addition of
4 marks and each wrong answer will lead to
deduction of one mark.
4

5. Eligibility for GPAT
• Bachelor’s degree holders in Pharmacy (4 years
after 10+2, including lateral entry candidates)
and those who are in the final year of B.
Pharmacy course ONLY are eligible for
appearing in GPAT
• Examination. [B. Pharmacy 1st year to 3rd
year students are NOT ELIGIBLE to appear
in GPAT Examination.
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6. SUBJECTWISE DISTRIBUTION OF
MARKS GATE (2000-2006)
29.3
18.6
7.3
9.3
18.6
25.3
14.6
Natural Products
Medicinal Chemistry
Pharmacology
Pharmaceutics
Pharmaceutical Analysis
Biochemistry
Microbiology
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7. METHODOLOGY
SYLLABUS
4 STAGES
TESTS
DISCUSSION
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8. Scheme of syllabus
Pharmacognosy
Sources of
Drugs:
Biological,
marine, mineral
and plant tissue
cultures as
sources of drugs;
Classification of
Drugs:
Morphological,
taxonomical,
chemical and
pharmacological
classification of
drugs.
Systematic
pharmacogn
ostic study
of the
following:
CARBOHY-
DRATES
RESINS,
TANNINS,
VOLATILE
OILS,
FIBERS
Study of the biological
sources, cultivation,
collection, commercial
varieties, chemical
constituents, substitutes,
adulterants, uses, diagnostic
macroscopic and microscopic
features and specific
chemical tests of following
groups of drugs:
GLYCOSIDE CONTAINING
DRUGS,ALKALOID
CONTAINING DRUGS
General Techniques of
Biosynthetic Studies
and Basic Metabolic
Pathways/Biogenesis:
Brief introduction to
biogenesis of
secondary metabolites
of pharmaceutical
importance. Plant
Tissue Culture,
Applications of plant
tissue culture in
pharmacognosy
8

9. Glycyrrhizin, a sweet principle of liquorice
is
a. K and Mg salts of glycyrrhizinic acid
b. Na and Mg salts of glycyrrhetinic acid
c. K and Ca salts of glycyrrhizinic acid
d. Na and Ca salts of glycyrrhetinic acid
Answer : C
9

10. The bitter glycoside gentiopicrin is
present in
A) Quassia
B) Wild cherry
C) Senegra
D) Gentian
Answer : A
10

11. Most volatile oils are rich in
A) Terpenes
B) Sulphur containing compounds
C) Lipoproteins
D) Glycosides
Answer: A
11

12. Pharmacology
General
Pharmacology
& Toxicology
Pharmacology
of Central
Nervous
System,
Autonomic
Nervous
System
Pharmacology of
Endocrine
System, Drugs
acting on the
uterus;
Chemotherapy,
Basic Concepts of
Pharmacotherapy
Pharmacology of
Cardiovascular
System, Drugs Acting
on the Hemopoietic
System, urinary
system, the Respiratory
System,
Gastrointestinal Tract
Pathophysiol
ogy of
common
diseases;
Basic
Principles of
Cell Injury
and
Adaptations
Pharmacolo
gy of
Autocoids,
hormones
12

13. A macrolide antibiotic used as a powerful
immunosuppressive agent is
a. Erythromycin
b. Azithromycin
c. Tacrollmus
d. Clarithromycin
Answer : c
13

14. The term that refers to the rapid
diminution of responsiveness following
administration of a drug is:
A) Hyporeactivity.
B) Tachyphylaxis.
C) Idiosyncratic drug response.
D) Tolerance.
Answer: B
14

15. Mechanism of action of triampterine
is…………..
A) Aldosterone antagonist
B) Block luminal Na+ channel
C) Block Na+/K+/2Cl- transport
D) Block Na+/Cl- transport
Answer: B
15

16. Pharmaceutical Chemistry
Inorganic
compounds in
pharmacy and
medicine; An
outline of methods
of preparation,
uses, sources of
impurities, tests for
purity and identity,
including limit tests
for iron, arsenic,
lead, heavy metals
etc
Fundamentals of
Physical
Chemistry in
pharmacy,
Behaviour of Gases,
The Liquid State,
Thermodynamics,
Quantum Mechanics
Organic Chemistry
Stereochemistry,
Preparation and
Reactions of:
Alkanes, Alkenes,
Alkynes, Cyclic
analogs, Dienes,
Benzene etc
Medicinal Chemistry
Physico-chemical and
stereoisomeric (Optical,
geometrical) aspects of drug
molecules and biological action,
Bioisosterism, Drug-receptor
interactions including
transduction mechanisms; Drug
metabolism and Concept of
Prodrugs; Principles of Drug
Design (Theoretical Aspects):
Traditional analog and
mechanism based approaches,
QSAR approaches, Applications
of quantum mechanics,
Computer Aided Drug Designing
(CADD) & molecular modeling
Synthetic
Procedures, Mode
of Action, Uses,
Structure Activity
Relationships
including
Physicochemical
Properties of the
Following Classes
of Drugs: ANS,
CNS, GIT,
respiratory system ,
Anticancer drugs,
antihypertensive,
antiviral drugs,
steroidal drugs etc.
16

17. 2-hydroxy-5,9-dimethyl-6,7-benzomorphan
derivative is
a. Pentazocine
b. Hydrocodone
c. Codeine
d. Buprenorphine
Answer : a
17

18. Drugs which are converted to fraudulent
nucleotides and inhibit thymidylate
synthetase belong to one of the
following class of drugs
A) Anti metabolites (purine analogs)
B) Anti metabolites (pyrimidine analogs)
C) Anticancer drugs
D) DNA intercalating agents
Answer: B
18

19. The compound is (_)-3-(3,4-
dihydroxyphenyl)-L-alanine. Select the
most appropriate statement below.
A) the compound is adrenaline
B) it is a dextrorotatory compound
C) it is a precursor of dopamine
D) it is used to treat hypertension
Answer :C
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20. Pharmaceutics & Pharmaceutical Jurisprudence
Introduction to
Physical
pharmacy;
Matter,
Properties of
Matter, Microme
retics and Powder
Rheology,
Surface and
Interfacial
Phenomenon,
Viscosity and
Rheology,
Dispersion
Systems,
Complexation, ,
Kinetics and
Drug Stability
Principles involved
and procedures
adopted in
dispensing of
solutions, emulsions,
ointments etc.
Incompatibilities,
Community
Pharmacy,
Organization and
Structure of hospital
pharmacy, Hospital
formulary, Drug
Store Management
and Inventory
Control, Drug
Information
Services
Importance of unit
operations in
manufacturing, Liquid
Dosages Forms,
Designing of dosage
forms; Pre-formulation
studies. New drug
delivery system,
Biopharmaceutics and
pharmacokinetics and
their importance in
formulation, ICH
Guidelines for stability
testing of formulations
Introduction to
pharmaceutical
jurisprudence &
ethics. study of the
different Acts with
special reference
to the main
provisions and the
latest
amendments:
Prescription/Non-
prescription
Products.
Medical/Surgical
accessories,
diagnostic aids,
appliances
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21. In cosmetic preparations, an antioxidant
used in aqueous system, is
a. Sodium formaldehyde sulphoxylate
b. -tocopherol
c. Methyl paraben
d. Phenol
Answer : a
21

22. Methyl and propylparahydroxy benzoic
acid are often used together in liquid
oral as a preservative in ratio of
A) 10:1
B) 1:10
C) 1:100
D) 2:10
Answer: B
22

23. Opthalmic preparations should not
contain particles of size __________ at
all.
A) >10 um
B) >25 um
C) >50 um
D) >100 um
Answer: A
23

24. Pharmaceutical Analysis
Principles,
instrumentation,
and
applications of
UV-VIS, IR
Fluorimetry,
Flame
photometry
Principles,
instrumentation
and
applications of
potentiometry
conductometry
and
polarography.
Principles of NMR,
ESR and Mass
Spectroscopy
Pharmacopoeial
assays (IP, Vol-I)
Principles of X-
ray diffraction
analysis,
chromatographic
techniques,
Pharmacopoeial
assays (IP, Vol-II)
24

25. Luminescence is the term applied to
a. Absorbed radiation
b. Re-emission of previously absorbed
radiation
c. Excited radiation
d. Transmitted radiation
Answer : B
25

26. The peaks obtained due to np* transition
are called as
A) R- bands
B) S- bands
C) P- bands
D) B- bands
Answer: A
26

27. The ultraviolet region of the spectrum
used in drug analysis
A) 50 - 200 nm
B) 200 - 400 nm
C) 200 - 750 nm
D) 400 - 600 nm
Answer: B
27

28. Microbiology
Importance of
microbiology in
pharmacy;
Structure of
bacterial cell;
Classification of
microbes and their
taxonomy
Immunology and
Immunological
Preparations, Genetic
Recombination.
Antibiotics: Historical
development of
antibiotics.
Antimicrobial spectrum
and methods used for
their standardization.
Identification of
Microbes. Control of
microbes by physical
and chemical methods,
Sterilization
28

29. Chemotaxis is a phenomenon that refers to
a. Directed movement in response to a
chemical stimulus
b. Taxonomic classification of biochemicals
c. Large in-flux of a chemical molecule
within bacterial cells
d. Adherence of bacterial proteins to host
cells
Answer : A
29

30. Which of the following is characteristic of
Corynebacterium diphtheria?
A) Gram negative cocci occurring in pair
or tetrad
B) Gram negative non spore forming
bacillus
C) Gram positive spore forming bacilli
D) Gram positive non-spore forming bacilli
Answer: D
30

31. Diversity in antibody molecule is brought
about by
a. Post-translational modifications
b. Gene rearrangements
c. Usage of special genetic codes
d. Multiple mutations in the poly peptide
Answer : b
31

32. Biochemistry
The concept of free
energy:
Determination of
change in free energy
– from equilibrium
constant and
reduction potential,
bioenergetics,
production of ATP
and its biological
significance
Biochemical role
of hormones,
Vitamins
enzymes,
coenzyme, and
nucleic acids
bioenergetics
32

33. The end products of the citric acid cycle
include all of the following except
A) CO2
B) NADH
C) pyruvic acid
D) FADH2
Answer: C
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34. 34

35. 35

36. 36

37. 37

38. 38

39. 39

40. 40

41. 41

42. 42

43. 43

44. 44

45. 45

46. 46

47. 47

48. 48

49. 48 A 49 D 50 A 51 A 52 D 53 A
54 B 55 A 56 D 57 B 58 B 59 B
60 A 61 C 62 B 63 B 64 C 65 B
66 C 96 C 97 D 98 D 99 A 100 D
101 A 102 B 103 C 104 D 105 B 106 A
107 C 108 B 109 A 110 D 111 C 112 C
113 B 114 C 115 C 116 A 117 B 118 B
119 A 120 B 121 A 122 B 154 A 155 C
156 A 157 D 158 C 159 A 160 C 161 D
162 B 163 C 164 C 165 B 166 C 167 A
Ref. - GPAT : A Companion – Inamdar N.N., 8th Edition
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50. Reference books suggested for preparation -
•Morrison Boyd & Bhattacharjee- Organic Chemistry
•Carey- Organic Chemistry
•Wilson & Gisvold’s – Textbook of Organic, Medicinal And
Pharmaceutical Chemistry, 2011
•Foye’s - Principles of Medicinal Chemistry, 2008
•Skoog , Holler , Nieman – Principles of Instrumental Analysis
•Willard, Merritt , Dean, Settle – Instrumental Methods of Analysis
•Martin’s – Physical Pharmacy & Pharmaceutical Sciences
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51. •Lachman & Lieberman’s - The Theory & Practice of Industrial
Pharmacy (4th Edition)
•Aulton M.E.- Pharmaceutics : The Science of Dosage Form Design
•Rang , Dale, Ritter, Moore, – Pharmacology
•Katzung – Basic & Clinical Pharmacology
•Trease and Evans –Pharmacognosy
•Wallis – Textbook of Pharmacognosy
•Shargel L. et al - Comprehensive Pharmacy Review
•Inamdar N.N - GPAT : A Companion (8th Edition)
•Remington : The Science and Practice of Pharmacy
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52. Thank you
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