in brief.. the oral immunity : ) NOTE : all this from my reading in some scientific website and articles I hope that you enjoy and you benefit❤

1. 1- Oral mucosa
 Keratinization.
 Granular layer.
 Basement membrane formation of immune complexes.
 Lymphoid cells may deal with any organisms which pass the overlying
barriers.
2- Oral lymphoid tissues
a- Extra-oral lymphoid tissue.
b- Intra-oral lymphoid tissue
1- Palatine tonsils.
2- Salivary gland lymphoid tissue.
3- Gingival lymphoid tissue (Plasma cells, lymphocytes, macrophage and
polymorphs).
4- Scattered submucosal lymphoid cells.
3- Saliva ( IgA )
 Its mechanical washing activity.
 It is rich in antimicrobial factors (lysozyme, peroxidase and lactoferrin).
 It secretes IgA which prevent microbial adherence to host surface.

2. 4- Gingival crevicular fluid
Function:
– Flushing effect.
– Transport the blood components as leucocytes from blood to reach the
oral cavity.
5- Humoral and cellular components in GCF and Salivary gland
secretion
• Innate immunity is non-specific and does not require prior exposure to infectious
agents.
• First line of innate immunity:
1. Physical barriers such as the epithelium.
2. Phagocytic cells such as neutrophils.
• The second line of innate immunity:
- inflammation which localize infectious agents at sites of mucosal penetration.
• Two mechanisms of complement activation:
1. Classical Pathway: Initiated by antibodies.
2. Alternative Pathway: Initiated by microbial polysaccharides.
 Composed of 15 to 20 amino acid.
 Produced by leukocytes.
 It interacts with bacterial cell membrane forming pores leading to
membrane disruption.
DONE BY :
GHADEER HASSAN