The MCA is the largest and most complex of the cerebral arteries. It arises from the internal carotid artery and has four segments - M1, M2, M3, M4. The M1 segment can be further divided into pre-bifurcation and post-bifurcation parts. Early branches and perforating arteries originate from the M1 segment. The MCA has a variable branching pattern and anomalies include duplication, accessory branches, and fenestration. Key angiographic landmarks include the Sylvian point and Sylvian triangle.