This document discusses glidants and anticaking agents. It defines glidants as substances added to powders to improve flowability by counteracting factors that cause poor flowability, such as by reducing surface irregularity and friction. Common glidants include magnesium stearate, aerosol, and colloidal silicon dioxide. Anticaking agents are defined as additives that prevent clumping in powders during packaging, transport, and use. They work by strongly adsorbing moisture to compete with moisture absorption by powder particles, thus reducing caking. Common anticaking agents listed are calcium carbonate, magnesium carbonate, and sodium aminosilicate.

1. GLIDANTS
ANTICAKING AGENTS
Presentation by D.A.Dasuni Prasadika
Bpharm

2. Content
■ Introduction of glidants
■ Functions and examples of glidants
■ Definition of anticaking agents
■ Examples of anticaking agents

3. Introduction of glidants
Glidant is a substance that is added to a powder to improve its
flowability.
■ A glidant’s effect is due to a counteraction of factors resulting in poor flowability of
powders.
■ For instance, correcting surface irregularity reducing interparticular friction.
■ The result is a decrease in the angle of repose which is an indication of an enhanced
powder’s flowability .

4. Functions of glidants.
■ To improve powder flowability
■ To reduce interparticular friction
■ To reduce the cohesion
Examples -:
■ Magnesium sterate
■ Aerosol , colloidal silicon dioxide
■ Starch and talc.

5. Definition of Anticaking agents
Anticaking agent is an additive placed in powdered or granulated materials to
prevent the formation of lumps, easing packaging,transport and consumption .
■ Function of anticaking agents
By competing with host powder for moisture anticaking agents have strong water adsorptive
ability.
So that they can compete with host powdered medicine product particles for available water
thus, reducing hygroscopicity consequently its tendency to cake.
So the function is adsorbing excess moisture or by coating particles and making them water
repellent .

6. Examples for anticaking agents
■ Calcium carbonate
■ Magnesium carbonate
■ Sodium aminosilicate
■ Sodium ferrocyanide
■ Potassium ferrocyanide

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