摘要 非酒精性脂肪性肝病是由于酒精滥用以外的其他原因引起的肝脂肪积累。多项研 究已经证明，NAFLD与胰岛素抵抗有关，导致在含有较多游离脂肪酸（FFA）的 脂肪组织中胰岛素抗脂解能力的降低。FFAs的增加还诱导了线粒体的功能障碍及 脂毒性的形成。此外，在具有NAFLD的受试者中，异位脂肪也沉积为心脏和胰腺 脂肪。在本次综述中，我们分析了NAFLD与代谢综合征和血脂异常相关的机制及 其与心血管疾病形成和发展的关系。

1. 非酒精性脂肪性肝病（NAFLD）及其与胰岛素抵抗、血脂异常、动脉粥样硬化和冠心病的关系
摘要
非酒精性脂肪性肝病是由于酒精滥用以外的其他原因引起的肝脂肪积累。多项研 究已经证明，NAFLD与胰岛素抵抗有关，导
致在含有较多游离脂肪酸（FFA）的 脂肪组织中胰岛素抗脂解能力的降低。FFAs的增加还诱导了线粒体的功能障碍及 脂毒性
的形成。此外，在具有NAFLD的受试者中，异位脂肪也沉积为心脏和胰腺 脂肪。在本次综述中，我们分析了NAFLD与代谢综
合征和血脂异常相关的机制及 其与心血管疾病形成和发展的关系。
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我们是医学图书馆馆员，我们正在进行一项探索非英语医学研究文章全球知名度的实验。 本摘要的翻译由经认证的翻译人员完成。
完整开放获取文章的PubMed引用和链接可在这 里找到 https://www.ncbi.nlm.nih.gov/pubmed/?term=23666091。请在下面输入您
对本项 目及译文质量的意见（如果您是母语人士）。
- 科罗拉多大学健康科学 图书馆 ，Lilian Hoffecker 和 Dana Abbey。

2. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia,
atherosclerosis and coronary heart disease.
Abstract
Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is
associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty
acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic
fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and
dyslipidemia and its association with the development and progression of cardiovascular disease.
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We are medical librarians conducting an experiment to understand the global visibility of non-English medical research articles. The translation for
this abstract was performed by a certified translator. The PubMed citation and link to the whole open access article can be found here
https://www.ncbi.nlm.nih.gov/pubmed/?term=23666091. lease feel free to add your comments below on the project and, if you are a native-
speaker, on the quality of the translation.
--Lilian Hoffecker and Dana Abbey, Health Sciences Library, University of Colorado.