摘要 背景： 并非所有肥胖受试者都有不利的代谢特征，使其容易发展为2型糖尿病或心血 管疾病。BioSHaRE-EU健康肥胖项目旨在通过在几个大型队列研究中取得的关 于风险因素和表型的数据，了解（健康型）肥胖症的后果。本研究的目的是通 过10个参与研究得出肥胖症、代谢综合征（MetS）和新陈代谢健康型肥胖症 （MHO）的患病率。

1. 代谢综合征和新陈代谢健康型肥胖症在欧洲的患病率：十个 队列研究的协同分析
摘要 背景：
并非所有肥胖受试者都有不利的代谢特征，使其容易发展为2型糖尿病或心血 管疾病。BioSHaRE-EU健康肥胖项目旨在通过在几个大型队列
研究中取得的关 于风险因素和表型的数据，了解（健康型）肥胖症的后果。本研究的目的是通 过10个参与研究得出肥胖症、代谢综合征
（MetS）和新陈代谢健康型肥胖症（MHO）的患病率。
方法：
使用已转化为统一格式的数据将七个国家的10个不同研究组结合起来。所有参加者均 为欧洲血统，年龄在18-80岁之间。 他们参加了人体
测量和血压测量的临床检查。抽 取了血液样本，用于分析脂质和葡萄糖。根据2001年NCEP ATP III标准以及一套经完 善的、不太严格的标准，
对肥胖症患者（BMI≥30kg / m2）的MetS进行了评估。MHO 的定义是不患有MetS，之前也没有心血管疾病诊断的肥胖症。
结果：
在163,517人的可用数据中，17％的人属于肥胖（11,465名男性和16,612名女性）。 肥胖患病率从11.6%（意大利的CHRIS研究组）到26.3％
（德国的KORA研究组）。 患有MetS的肥胖症受试者的年龄标准化百分比的范围为，女性从24%（CHRIS研究 组）到65%（芬兰健康2000研
究组），男性从43%（CHRIS）到78%（芬兰DILGOM研 究组），其中血压升高是诱导较高代谢综合征患病率的最常见的因素。MHO的年龄
标准化患病率为，女性从7％（Health2000）到28%（NCDS），男性从2％（DILGOM）到19％（CHRIS）。女性MHO的患病率高于男性，但
随着年龄的增长而下降。

2. 结论：
通过严格的协调过程，BioSHaRE-EU的研究人员能够通过10个队列研究来比较对新陈 代谢健康型肥胖表型有界定作用的关键特征。尽管使用统
一标准对这种表型进行分 类，但在所研究的不同欧洲人群中，健康型肥胖症的患病率仍有相当大的变化
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- 科罗拉多大学健康科学图书馆，Lilian Hoffecker 和 Dana Abbey。

3. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of
ten large cohort studies.
Abstract
BACKGROUND:
Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-
EU Healthy Obese Project aims to gain insights into the consequences of (healthy) obesity using data on risk factors and phenotypes across several
large-scale cohort studies. Aim of this study was to describe the prevalence of obesity, metabolic syndrome (MetS) and metabolically healthy
obesity (MHO) in ten participating studies.
METHODS:
Ten different cohorts in seven countries were combined, using data transformed into a harmonized format. All participants were of European origin,
with age 18-80 years. They had participated in a clinical examination for anthropometric and blood pressure measurements. Blood samples had
been drawn for analysis of lipids and glucose. Presence of MetS was assessed in those with obesity (BMI ≥ 30 kg/m2) based on the 2001 NCEP ATP III
criteria, as well as an adapted set of less strict criteria. MHO was defined as obesity, having none of the MetS components, and no previous
diagnosis of cardiovascular disease.
RESULTS:
Data for 163,517 individuals were available; 17% were obese (11,465 men and 16,612 women). The prevalence of obesity varied from 11.6% in the
Italian CHRIS cohort to 26.3% in the German KORA cohort. The age-standardized percentage of obese subjects with MetS ranged in women from
24% in CHRIS to 65% in the Finnish Health2000 cohort, and in men from 43% in CHRIS to 78% in the Finnish DILGOM cohort, with elevated blood
pressure the most frequently occurring factor contributing to the prevalence of the metabolic syndrome. The age-standardized prevalence of MHO
varied in women from 7% in Health2000 to 28% in NCDS, and in men from 2% in DILGOM to 19% in CHRIS. MHO was more prevalent in women than
in men, and decreased with age in both sexes.

4. CONCLUSIONS:
Through a rigorous harmonization process, the BioSHaRE-EU consortium was able to compare key characteristics defining the metabolically
healthy obese phenotype across ten cohort studies. There is considerable variability in the prevalence of healthy obesity across the different
European populations studied, even when unified criteria were used to classify this phenotype.
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We are medical librarians conducting an experiment to understand the global visibility of non-English medical research articles. The translation
for this abstract was performed by a certified translator. The PubMed citation and link to the whole open access article can be found here
https://www.ncbi.nlm.nih.gov/pubmed/?term=24484869. Please feel free to add your comments below on the project and, if you are a native-
speaker, on the quality of the translation.
--Lilian Hoffecker and Dana Abbey, Health Sciences Library, University of Colorado.