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By
Dr. Salahuddin M. Kamal
(Prof. Emeritus in EAEA)
Associate Professor
Medical Radiation Physics
King Abdulaziz University
Faculty of Medical Applied Sciences
Diagnostic Radiology Department
Radiobiology
and
Radiation Protection
(Rad-222)
Radiobiology
When x-rays enter the body, they interact at
the atomic level to cause ionization.
Radiobiology is the response of living
systems to ionizing radiation.
Ionization
Ionization is the process of removing an electron
from an electrically neutral atom to produce an
ion pair. An ion is an atom or subatomic particle
with a positive or negative charge.
Ionization negative ion
(electron)
positive ion: atom with
3 protons, 2 electrons
X-ray enters atom and strikes
electron, knocking it out of its
orbit and creating two ions (ion
pair). The ejected electron is the
negative ion and the atom with a
net positive charge is the positive
ion.
++
+
Ionizing Radiation
The two types of ionizing radiation are electromagnetic
and particulate.
Electromagnetic: Electromagnetic radiation has both
electrical and magnetic properties. It includes x-rays
and gamma rays. X-rays are produced by a machine
and gamma rays are produced when radioactive
materials decay. Neither one has any mass.
Particulate: Particulate radiation consists of particles
that have mass and travel at high speeds. Included are
alpha particles (helium nuclei), electrons (beta
particles; also called beta rays), protons and neutrons.
Attenuation
Attenuation is the reduction of the x-ray beam
intensity by interaction with the tissue that the x-
rays pass through. The three types of interactions
are:
1. Coherent scattering
2. Compton scattering
3. Photoelectric absorption
Approximately 9% of the x-rays pass through the
tissues without any interactions.
Coherent Scattering
A low-energy x-ray interacts with an outer-
shell electron and causes it to vibrate briefly.
A scattered x-ray of the same energy as the
primary x-ray is then emitted, going in a
different direction than the primary x-ray. An
electron is not ejected from the atom. (No
ionization). This interaction occurs about 8%
of the time.
primary x-ray
strikes electron
in outer shell
scattered x-ray emitted
with same energy as
primary x-ray, different
direction
Coherent Scattering
electron vibrates
Compton Scattering
In Compton Scattering, an outer shell
electron is ejected when struck by an x-ray,
creating an ion pair (ionization). The primary
x-ray loses some of its energy and continues
in a different direction as a scattered x-ray.
Compton Scattering accounts for about 62%
of the interactions occurring within the
tissues.
Approximately 30% of the scattered x-rays
exit the head.
ejected electron
(negative ion)
Compton Scattering
primary x-ray
The primary x-ray strikes an outer-shell electron,
knocking it out of its orbit (ionization). The primary x-ray
loses some of its energy and continues in a different
direction as a scattered x-ray.
atom with net
positive charge
is positive ion
scattered x-ray
Photoelectric Absorption
In Photoelectric Absorption, an inner-shell
electron is ejected when struck by an x-ray,
creating an ion pair (ionization). The primary
x-ray loses all of its energy in knocking the
electron out of its orbit; the x-ray ceases to
exist (no scatter radiation). Photoelectric
Absorption accounts for about 30% of the
interactions occurring within the tissues.
Photoelectric Absorption
The primary x-ray strikes an inner-shell electron,
knocking it out of its orbit (ionization). The x-ray loses
all of its energy and disappears. There is no scatter.
ejected electron
(negative ion)
atom with net
positive charge
(positive ion)
threshold
linear
non-linear
Dose-Response Curves
non-threshold
Response
Dose
Dose-Response curves represent the relationship
between the dose of radiation a person receives and
the cellular response to that exposure. These
responses may be linear or non-linear and may, or may
not, have a threshold dose; the responses (effects)
may be stochastic or deterministic. (See next two
slides for definitions of these terms).
Linear: the response is directly related to the dose. As
the dose increases, the response increases
proportionately.
Non-linear: the response is not proportionate to the
dose. An increase in dose may result in a larger or
smaller increase in the response depending on the
location on the dose-response curve.
Threshold: this represents the dose at which effects
are produced; below this dose, there are no obvious
effects.
Non-threshold: any dose, no matter how small, will
produce a response.
Stochastic effect: occurs by chance, usually without
a threshold level of dose. The probability of a
stochastic effect is increased with increasing doses,
but the severity of the response is not proportional
to the dose (e.g., two people may get the same dose
of radiation, but the response will not be the same
in both people). Genetic mutations and cancer are
the two main stochastic effects.
Deterministic effect: health effects that increase in
severity with increasing dose above a threshold
level. Usually associated with a relatively high dose
delivered over a short period of time. Skin erythema
(reddening) and cataract formation from radiation
are two examples of deterministic effects.
DNA
Radiation effects at the cellular level
result from changes in a critical or
“target” molecule. This target molecule
is DNA (deoxyribonucleic acid), which
regulates cellular activity and contains
genetic information needed for cell
replication. The DNA molecule is called
a chromosome. Permanent changes in
this molecule will alter cell function and
may result in cell death.
Direct vs. Indirect Effect
DNA
If an x-ray or some type of particulate radiation
interacts with the DNA molecule, this is
considered a direct effect. Particulate radiation,
because of its mass, is more apt to cause damage
to the DNA by this direct effect. Other molecules
that contribute to cell function, such as RNA,
proteins, and enzymes, may also be affected by
the direct effect.
x-ray or particulate
radiation
Direct effect
=
Direct vs. Indirect Effect
H2O ions and
free radicals
Most of the damage to DNA molecules from x-rays is
accomplished through the indirect effect. When x-rays
enter a cell, they are much more likely to hit a water
molecule because there are a large number of water
molecules in each cell. When the x-ray ionizes the
water molecule, ions and free radicals are produced
which in turn bond with a DNA molecule, changing its
structure. Since the x-ray interacted with the water
molecule before the DNA was involved, this is
considered an indirect effect.
x-ray or particulate
radiation
DNA =
Indirect
effect
A free radical is an atom or molecule that has
an unpaired electron in the valence shell,
making it highly reactive. These free radicals
aggressively join with the DNA molecule to
produce damage. In the presence of oxygen,
the hydroperoxyl free radical is formed; this is
one of the most damaging free radicals that
can be produced. Free radicals are the
primary mediator of the indirect effects on
DNA.
Free Radical
Cells undamaged: ionization alters the structure of
the cells but has no overall negative effect.
Sublethal injury: cells are damaged by ionization
but the damage is repaired.
Mutation: cell injury may be incorrectly repaired,
and cell function is altered or the cell may
reproduce at an uncontrolled rate (cancer).
Cell death: the cell damage is so extensive that the
cell is no longer able to reproduce.
Cellular Effects
Sublethal Injury: Cellular Repair
1. Ionization causes damage to DNA
(single-strand break of DNA).
2. Cellular enzymes recognize the damage
and coordinate the removal of the
damaged section.
3. Additional cell enzymes organize
replacement of the damaged section with
new material.
When the DNA is damaged,
cell function may be altered
or reproductive capacity may
be accelerated. Cancer is the
most harmful result of
cellular mutation.
Mutation
Normal
Mutation
Cell Death
If there is extensive damage to the cell following
irradiation or if cell division (mitosis) is disrupted,
the cell may die. This will depend on how
sensitive the cells are to radiation. The loss of a
few cells or small group of cells is usually of no
consequence, since there are so many cells
present in the body. In most cases, the dead cells
will soon be replaced through normal reparative
processes.
Cell Cycle
More damage results when the cell is irradiated during
the G1/early S portion of the cell cycle (before DNA
synthesis); the damaged DNA (chromosome) will be
duplicated during DNA synthesis and will result in a
break in both arms of the chromosome at the next
mitosis.
G1 = gap phase 1 in which nuclear
components are replicated
S = synthesis phase; DNA is
synthesized during the last 2/3 of
this phase
G2 = gap phase 2, a preparatory
stage to cell division
M = mitosis, during which cells
divide
Cell most sensitive
to radiation
1. High reproductive rate (many mitoses)
2. Undifferentiated (immature)
3. High metabolic rate
Radiosensitive Cells
Cells that are more easily damaged by radiation are
radiosensitive. The characteristics of radiosensitive
cells are:
Lymphocytes, germ cells, basal cells of skin and
mucosa, and erythroblasts are examples of
radiosensitive cells.
Radioresistant Cells
1. Low reproductive rate (few mitoses)
2. Well differentiated (mature)
3. Low metabolic rate
Cells that are not as susceptible to damage from
radiation are radioresistant. The characteristics of
radioresistant cells are:
Nerve and muscle cells are examples of
radioresistant cells.
Radiation Effect Modifiers
The biological response to radiation is dependent on
several different factors. These include:
• Total Dose: the higher the radiation dose, the
greater the potential cellular damage.
• Dose Rate: A high dose given over a short
period of time (or all at once) will produce more
damage than the same dose received over a
longer period of time.
• Total Area Covered: the more cells that are
exposed to radiation, the greater the effects will
be.
Radiation Effect Modifiers (continued)
• Type of tissue: As discussed earlier,
radiosensitive cells are more likely to be
damaged by radiation than are radioresistant
cells.
• Age: Because the cells are dividing more
frequently in a growing child, young people are
affected more by radiation than are older people.
• Linear Energy Transfer: This measures the rate
of the loss of energy as radiation moves
through tissue. Particulate radiation (alpha
particles, electrons, etc.) has a higher LET
because it has mass and interacts with
tissues much more readily than do x-rays.
• Oxygen Effect: Radiation effects are more pronounced
in the presence of oxygen. Oxygen is required for the
formation of the hydroperoxyl free radical, which is
the most damaging free radical formed following
ionization.
Radiation Effect Modifiers (continued)
The amount of exposure a patient receives
from dental diagnostic radiography (effective
dose) is relatively small. Most of the radiation
damage will be repaired. The effects of the
radiation damage that is not repaired may not
show up for many years. The time between the
exposure and the appearance of the effects of
that exposure is called the latent period. In
general, the higher the dose, the shorter the
latent period.
Latent Period
Since repair of radiation injury is not 100%,
radiation effects are accumulative. However,
these effects will usually not be noticeable,
since they are masked by the normal aging
processes.
The effects from extreme levels of radiation
exposure are potentially life threatening.
Since these high levels will never be seen
with diagnostic radiography, the effects will
not be discussed. Check radiology texts or
online sources for more information.
Somatic Cells vs. Germ Cells
There are two general types of cells in the body; these
are somatic and genetic. Somatic cells are all the cells
except for the germ (reproductive) cells. If somatic
cells are irradiated, only the person exposed will be
affected. Germ cells are the sperm and ova. If the germ
cells are irradiated, the offspring of the individual may
be affected.
Hormesis
Hormesis is a dose response phenomenon in which
small doses of a toxin have the opposite effect of
large doses. For example, exposing mice to small
doses of radiation shortly before exposing them to
very high levels of radiation actually decreases the
likelihood of cancer. The initial low dose of radiation
may activate certain repair mechanisms in the body
and these mechanisms are efficient enough to not
only neutralize the radiation effects but may even
repair other defects not caused by the radiation.
There is a lot of debate about hormesis, but the
general opinion is that this is not something that can
be relied on when discussing the effects of radiation
exposure.
Dosimetry
Measuring the dose of radiation emitted
by a radioactive source.
As mentioned previously, radiation effects are
dependent on the total area covered. If the entire body
is exposed, it would be considered whole-body
radiation. If only a localized area is exposed, as in
dental radiography, it would be called specific-area
radiation. The effects from a given dose of radiation
would be expected to be more severe if the whole
body is exposed to that dose rather than a specific
area.
Traditional Units SI* Units
Roentgen (R) Coulombs per kilogram
rad Gray
rem Sievert
Units of Radiation Measurement
* SI = International System of Units; used worldwide
Roentgen
The Roentgen (R) is the traditional unit of
measuring radiation exposure. This measures
the ionization of air. (The exact definition of
Roentgen is complicated and not worth
remembering). The Roentgen measures
radiation quantity before the radiation enters
the body. There is no exact SI unit comparable
to the Roentgen, but in keeping with the metric
system it is measured in coulombs per
kilogram.
The rad (radiation absorbed dose) is the traditional
unit used to measure the energy absorbed by the
body. The SI unit is the Gray (Gy). 1 Gray = 100
rads; 1 cGy (centiGray) = .01 Gray = 1 rad.
rad/Gray
The rem (roentgen equivalent man) is the traditional
unit used for comparing the effects of different types
of ionizing radiation (electromagnetic and particulate).
The dose (in rads) is multiplied by a quality
(weighting) factor. The quality factor for x-rays is 1.
Therefore the dose in rems (dose equivalent) is the
same as the dose in rads. For alpha particles the
quality factor is 20. Therefore the dose in rems (dose
equivalent) would be 20 times the dose in rads for
alpha particles. The higher the LET, the higher the
qualifying factor.
The SI unit is the Sievert (Sv). 1 Sievert = 100 rems;
1cSv (.01 Sievert) = 1 rem.
rem/Sievert
1 R = 1 rad = 1 rem
1 Gray = 1 Sievert = 100 rads = 100 rems
c (centi) = .01 m (milli) = .001 µ (micro) = .000001
1000 mrem = 1 rem = 1 cSv
100 mrem = 1 mSv = 1000 µSv
1 Sv = 100 cSv = 1,000 mSv = 1,000,000 µSv
* For x-rays, not particulate radiation
Conversions*
Each year, people are exposed to various types of
ionizing radiation (listed below) and receive an average
dose of 3.6 mSv (360 mrem ) per year. The actual dose
depends on the degree of exposure to the ionizing
radiation sources.
Radon 2 mSv(55%)
Cosmic 0.27 mSv (8%)
Rocks/soil 0.28 mSv (8%)
Food/water 0.4 mSv (11%)
Medical x-rays 0.39 mSv (11%)
Nuclear medicine 0.14 mSv (4%)
Consumer products 0.1 mSv (3%)
Other sources <0.01 mSv (<1%)
Annual Radiation Exposure
Natural (Background) Radiation
Environmental radiation that we are exposed to daily is
called natural or background radiation. It is composed
of both external and internal sources. Background
radiation averages 3.0 mSv (300 mrem) per year.
External Sources:
Cosmic (8%*): Ionizing radiation from space.
Increased exposure at higher altitudes and
during airline travel.
Terrestrial (8%*): Results from radioactive
materials in soil and rocks. May be incorporated
into some building materials. (See next slide).
* Percent of average annual radiation exposure
Certain black sand beaches in
Brazil produce radiation levels as
high as 5 mrem/hour. This would
be equivalent to getting a full
series of x-ray films every hour
(photo left).
Some plants in another area of
Brazil have absorbed so much
radium that they will produce an
autoradiograph when placed on
photographic paper (photo right).
Natural (Background) Radiation
(continued)
Internal Sources:
Radon (55%*): Radon and its decay products
enter our homes via the atmosphere and water.
Inhalation of these products contributes more
than half of our average annual radiation
exposure.
Food/Water (11%*): Some of the food and water
we ingest contains radioactive materials.
* Percent of average annual radiation exposure, both natural and artificial
Artificial (Man-made) Radiation
Artificial radiation results in an annual exposure of
about 0.6 mSv (60 mrem). Included are:
Medical X-rays (11%*): Diagnostic medical x-rays are
the major component of artificial radiation.
Therapeutic x-rays contribute a small portion. Dental
x-rays account for only 0.1% of the total annual
exposure.
Nuclear medicine (4%*): Diagnostic and therapeutic
Consumer Products (3%*): Dental porcelain, smoke
alarms, televisions, airport inspections, etc..
Other Sources (<1%*): Primarily nuclear fallout
* Percent of average annual radiation exposure, both natural and artificial
Effective Dose Equivalent
Exposure and dose are not related to the amount or
type of tissue covered by the x-ray beam. A dose (or
exposure) of 1 Sv could cover just the teeth or the
entire body. Obviously, the overall effects would be
different, even though the dose is the same. The
effective dose equivalent takes into account the
dose, the volume of tissue covered and the
radiosensitivity of the cells. Using the effective dose
equivalent, different types of x-ray examinations can
be more realistically compared regarding the risk
factor of each. The following slide lists the effective
dose equivalents for some typical radiographic
exams.
Effective Dose Equivalent
AFM* (round, F) 60 µSv
AFM* (rect., F) 27 µSv
Panoramic 7 µSv
Ceph 220 µSv
Chest 80 µSv
Upper GI 2400 µSv
Natural Radiation 3000 µSv
Notice that the effective dose equivalent for natural
(background) radiation (to which everyone is
exposed) is 50 times as much as that for an AFM with
round collimation and using F-speed film.
*AFM = adult full mouth series of x-ray films
Comparable risk from:
AFM (cancer)
Smoking 1 cigarette (cancer)
Drinking 30 cans of diet soda (cancer)
Riding a bicycle 10 miles (accident)
Driving a car 300 miles (accident)
Flying 1000 miles (accident)
The preceding slide shows that taking a complete
series of radiographs increases the average yearly
exposure to the patient by a very small amount. The
risk ( of cancer formation) is increased slightly. The
following table compares this risk with the risk
involved in common activities or habits.
The accepted cumulative dose of ionizing radiation during
pregnancy is 5 rad (.05 Sv). According to the American
Academy of Family Physicians, you would need 50,000
dental x-ray examinations to reach the 5-rad cumulative
dose to the fetus.
An airline flight of 5 hours results in an exposure of 25 µSv.
The exposure to the pelvic region from a full-mouth series
of radiographs (done properly) is 1 µSv. (average natural
(background) radiation is 8 µSv per day).
The decision to order films during pregnancy is a personal
one. Because of the relatively low dose, it is not expected
that there will be any harm to the fetus. However, my
recommendation is to limit the films to those needed to
treat the patient during the pregnancy (symptomatic teeth
or very active caries).
Pregnancy
Radiation Protection
for
Patient and Operator
Maximum Permissible Dose (MPD)
The maximum permissible dose is the amount of
radiation (dose limit) that a person can receive
from artificial radiation (effective dose equivalent).
These dose limits are recommended by the
NCRP* and required by the state in which a
dentist practices. The dose limits may vary
between the NCRP and the state.
There are no dose limits for patients being
radiographed. The dentist should only order films
that are needed for a diagnosis, and thus keep
patient exposure to a minimum (See ALARA).
* National Council on Radiation Protection and Measurements
Dose limits (MPD’s) are set for occupationally
exposed personnel (dentist, dental hygienist, and
dental assistant) and for non-occupationally
exposed individuals (front-office staff, people in
waiting room, etc.). The dose limits are as follows:
Maximum Permissible Dose (MPD)
Occupationally exposed:
Adult 50 mSv (NCRP & Ohio)
Minor 5 mSv (Ohio)
Pregnant 5 mSv (Ohio)
Non-Occupationally exposed:
NCRP 5 mSv
Ohio 1 mSv
Patient Protection
It is important to do everything we can to reduce the
amount of exposure when a patient has dental
radiographs taken. The following slides identify the
ways in which we can do this.
ALARA
ALARA stands for “As Low As Reasonably Achievable”.
If we assume that there is no threshold for stochastic
effects (mutations and cancer) to occur, then it is
important to keep the exposure to the minimum needed
to provide an accurate diagnosis. In other words, take
only those films needed to properly identify patient
problems.
Professional Judgment/Selection Criteria
Deciding which films are needed for a particular patient
is dependent on two things: Professional Judgment and
Selection Criteria.
Professional Judgment: Through education and
experience, each dentist develops an expertise in
deciding which films will be needed to obtain an
accurate diagnosis.
Selection Criteria: In 2005, the ADA, in conjunction with
the Food and Drug Administration, released updated
guidelines for prescribing dental radiographs. These
guidelines identify which films should be taken, based
on clinical findings. (For more detailed discussion, see
“Self-study: Patient Management/Film Ordering”)
Equipment Reliability
X-ray equipment must be functioning properly to
insure that the patient does not receive unnecessary
radiation exposure. The settings for the exposure
factors (exposure time, mA, kVp) must accurately
reflect the output. Each state has requirements for the
inspection of x-ray equipment to make sure that
everything is working properly. The Ohio Department
of Health requires that equipment be checked every
five years (fee charged) and that the operator renew
the registration of the equipment every two years (fee
charged). If new x-ray equipment is purchased or if an
x-ray unit is received from another dentist, the state
must be notified. Disposal of old units must also be
documented.
Direct Current (Constant Potential)
60-cycle Alternating Current
Many machines now convert the alternating current
into a direct current (constant potential). Instead of
cycles going from zero to the maximum, both positive
and negative, the voltage stays at the maximum
positive value, creating more effective x-ray
production. This allows for shorter exposure times and
a 20% reduction in patient exposure.
Constant Potential X-ray Machine
Filtration
Low-energy x-rays do not contribute to the formation
of an x-ray image; all they do is expose the body to
radiation. Therefore, we need to get rid of them. The
process of removing these low-energy x-rays from
the x-ray beam is known as filtration. Filtration
increases the average energy (quality) of the x-ray
beam. The x-ray beam becomes more penetrating,
providing good image formation on the film with
reduced patient exposure. (See “Self-study: X-ray
Production” for more information on filtration).
Low-energy
x-rays
high-energy
x-ray
Collimation
Collimation is used to restrict the size of the x-ray beam,
covering the entire film with the x-ray beam but not
exposing unnecessary tissue. By reducing the amount
of tissue exposed, the production of scatter radiation is
also reduced.
The shape of the opening (round or rectangular) in the
collimator determines the shape of the x-ray beam. The
size of the opening determines the size of the beam at
the end of the PID. If you switch from a 7 cm diameter
round PID to a 6 cm diameter round PID, the patient
receives 25% less radiation. Rectangular collimation
results in the patient receiving 55 % less radiation when
compared to what they would receive with a 7 cm round
PID. (See “Self-study: X-ray Production” for more on
collimation).
Focus Film Distance
Extending the distance between the target of the x-
ray tube (focal spot) and the teeth makes the beam
less divergent as it passes through the head,
exposing a smaller area of the patient. (The diameter
of the beam at the skin surface is the same for both
distances. The beam from the 8” target-teeth
distance spreads out much more as it passes
through the head).
16” 8”
Target-teeth
16”
Target-teeth
8”
Using a faster film requires less radiation. Using
F-speed film (Insight) instead of D-speed film
reduces patient exposure by 60%. F-speed film
has larger silver halide crystals, which more
readily intercept the x-rays. (See “Self-study:
Film and Screens” for more on films).
Intraoral Film Speed
Extraoral Screen Speed
Extraoral films are exposed by light from intensifying
screens; this light is produced when x-rays contact
phosphor crystals on the surface of the screens. The
light is either blue or green, depending on the type of
screen. Intensifying screens have different speeds,
depending on the type of phosphor crystal (rare earth
recommended) and the thickness of the phosphor layer.
The faster the screen is, the less the patient exposure
will be. However, image detail decreases as the speed
of the screens increases. It is important to make sure
that the film is compatible with the color of light coming
from the screen. (See “Self-study: Film and Screens”
for more on screens).
The American Dental Association
recommends that a lead apron and
thyroid collar be used on all patients.
The actual exposure from scatter
radiation to other parts of the body is
minimal, but considering the ease of
placing the lead apron and thyroid
collar, there is no reason not to use
them. Patients will appreciate your
efforts in keeping their exposure to a
minimum. (The thyroid collar is not
used for panoramic films).
Lead Apron/Thyroid Collar
Good technique in taking films is essential in
producing diagnostic radiographs. Proper film
placement and selection of the correct
exposure factors will maximize the value of
the films and will reduce or eliminate the need
for retakes, which would increase the patient’s
overall exposure.
Technique
Processing
Processing films for the correct amount of time
and at the proper temperature produces films of
good diagnostic quality, assuming the films were
exposed properly. It is necessary to have
appropriate safelighting in a light-tight
darkroom. Inadequate processing will result in
retaking films which will add to the patient’s
overall radiation exposure. (See “Self-study:
Processing”).
The operator should never hold films in the
patient’s mouth during an exposure. Some
patient’s, due to physical or mental impairments,
may need help in stabilizing the films, but this
assistance should be provided by a friend or
relative of the patient. This person should wear a
lead apron and leaded gloves when holding films
in the patient’s mouth.
X-ray Protection for the Operator
The photo at right shows a
squamous cell carcinoma on the
finger of a dentist who routinely
held films for the patient.
The operator should stand behind a protective
barrier if available. It has been determined that
drywall is adequate protection for this purpose.
The operator must be able to observe the patient
during the exposure to make sure the patient
doesn’t move prior to or during the exposure. If a
direct line of sight is not possible, mirrors can be
mounted on a wall opposite the doorway to allow
visualization of the patient.
If barriers are not available, the operator should
follow the position and distance rule (next slide).
X-ray Protection for the Operator
Position and Distance Rule
The operator should stand at least six feet away from
the patient at an angle between 90 and 135 degrees. As
the tubehead is moved, this safe position will change
relative to the patient’s head (see below).
State Requirements
All states have some regulations concerning the
operation of x-ray equipment. In Ohio, each dental
office must designate a Radiation Safety Officer (any
office employee; dentist, dental assistant, hygienist,
etc.) who is responsible for maintaining records
relating to the x-ray practices. Each office must post a
“Notice to Employees”, which briefly lists the
responsibilities of the dentist and all employees who
take radiographs as detailed in the state’s radiation
protection rules. Each office must have a “Safe
Operating Procedures” manual and each operator
must sign an “Instruction of Individuals” form to
indicate that they have read the manual.
Personnel-monitoring devices (film badges) can be
used to determine the exposure an operator receives
during a given period (often quarterly). Film badges
are required in some states if you expect to exceed
25% of the MPD during any calendar quarter (12.5
mSv). Although you should not expect to exceed this
dose following normal safe operating procedures, it is
beneficial to have a dosimetry service. The cost is
minimal and the reports, which hopefully identify the
lack of exposure to the operators, reduces any
apprehension the office staff may have about
radiation exposure.
Film Badges
NCRP Report # 145
The NCRP Report # 145 was released in December,
2003. It listed the following recommendations.
The lead apron is not required. The thyroid collar is
required for children and should be used for adults.
(The ADA, in response to the National Academy of
Science report on low-level radiation effects,
recommends lead apron/thyroid collar for all
patients).
Rectangular collimation is required for periapicals
and should be used, when feasible, for bitewings.
NCRP Report # 145
D-speed film is not to be used. E-speed film or
faster is required. (Kodak no longer makes E-speed
film; F-speed film, which is faster, is available along
with D-speed). Rare earth screens are to be used
for pans.
Sight development (dip tanks) is not acceptable.
Shielding design for new or remodeled dental
offices is to be done by a qualified expert.
Film badges are required for pregnant personnel.
This concludes the section on Radiobiology,
Dosimetry, and Radiation Protection.
Additional self-study modules are available
at: http://dent.osu.edu/radiology/resources.htm
If you have any questions, you may e-mail me
at: jaynes.1@osu.edu
Robert M. Jaynes, DDS, MS
Director, Radiology Group
College of Dentistry
Ohio State University

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Radiobiology Lec.ppt

  • 1. By Dr. Salahuddin M. Kamal (Prof. Emeritus in EAEA) Associate Professor Medical Radiation Physics King Abdulaziz University Faculty of Medical Applied Sciences Diagnostic Radiology Department Radiobiology and Radiation Protection (Rad-222)
  • 2. Radiobiology When x-rays enter the body, they interact at the atomic level to cause ionization. Radiobiology is the response of living systems to ionizing radiation.
  • 3. Ionization Ionization is the process of removing an electron from an electrically neutral atom to produce an ion pair. An ion is an atom or subatomic particle with a positive or negative charge. Ionization negative ion (electron) positive ion: atom with 3 protons, 2 electrons X-ray enters atom and strikes electron, knocking it out of its orbit and creating two ions (ion pair). The ejected electron is the negative ion and the atom with a net positive charge is the positive ion. ++ +
  • 4. Ionizing Radiation The two types of ionizing radiation are electromagnetic and particulate. Electromagnetic: Electromagnetic radiation has both electrical and magnetic properties. It includes x-rays and gamma rays. X-rays are produced by a machine and gamma rays are produced when radioactive materials decay. Neither one has any mass. Particulate: Particulate radiation consists of particles that have mass and travel at high speeds. Included are alpha particles (helium nuclei), electrons (beta particles; also called beta rays), protons and neutrons.
  • 5. Attenuation Attenuation is the reduction of the x-ray beam intensity by interaction with the tissue that the x- rays pass through. The three types of interactions are: 1. Coherent scattering 2. Compton scattering 3. Photoelectric absorption Approximately 9% of the x-rays pass through the tissues without any interactions.
  • 6. Coherent Scattering A low-energy x-ray interacts with an outer- shell electron and causes it to vibrate briefly. A scattered x-ray of the same energy as the primary x-ray is then emitted, going in a different direction than the primary x-ray. An electron is not ejected from the atom. (No ionization). This interaction occurs about 8% of the time.
  • 7. primary x-ray strikes electron in outer shell scattered x-ray emitted with same energy as primary x-ray, different direction Coherent Scattering electron vibrates
  • 8. Compton Scattering In Compton Scattering, an outer shell electron is ejected when struck by an x-ray, creating an ion pair (ionization). The primary x-ray loses some of its energy and continues in a different direction as a scattered x-ray. Compton Scattering accounts for about 62% of the interactions occurring within the tissues. Approximately 30% of the scattered x-rays exit the head.
  • 9. ejected electron (negative ion) Compton Scattering primary x-ray The primary x-ray strikes an outer-shell electron, knocking it out of its orbit (ionization). The primary x-ray loses some of its energy and continues in a different direction as a scattered x-ray. atom with net positive charge is positive ion scattered x-ray
  • 10. Photoelectric Absorption In Photoelectric Absorption, an inner-shell electron is ejected when struck by an x-ray, creating an ion pair (ionization). The primary x-ray loses all of its energy in knocking the electron out of its orbit; the x-ray ceases to exist (no scatter radiation). Photoelectric Absorption accounts for about 30% of the interactions occurring within the tissues.
  • 11. Photoelectric Absorption The primary x-ray strikes an inner-shell electron, knocking it out of its orbit (ionization). The x-ray loses all of its energy and disappears. There is no scatter. ejected electron (negative ion) atom with net positive charge (positive ion)
  • 12. threshold linear non-linear Dose-Response Curves non-threshold Response Dose Dose-Response curves represent the relationship between the dose of radiation a person receives and the cellular response to that exposure. These responses may be linear or non-linear and may, or may not, have a threshold dose; the responses (effects) may be stochastic or deterministic. (See next two slides for definitions of these terms).
  • 13. Linear: the response is directly related to the dose. As the dose increases, the response increases proportionately. Non-linear: the response is not proportionate to the dose. An increase in dose may result in a larger or smaller increase in the response depending on the location on the dose-response curve. Threshold: this represents the dose at which effects are produced; below this dose, there are no obvious effects. Non-threshold: any dose, no matter how small, will produce a response.
  • 14. Stochastic effect: occurs by chance, usually without a threshold level of dose. The probability of a stochastic effect is increased with increasing doses, but the severity of the response is not proportional to the dose (e.g., two people may get the same dose of radiation, but the response will not be the same in both people). Genetic mutations and cancer are the two main stochastic effects. Deterministic effect: health effects that increase in severity with increasing dose above a threshold level. Usually associated with a relatively high dose delivered over a short period of time. Skin erythema (reddening) and cataract formation from radiation are two examples of deterministic effects.
  • 15. DNA Radiation effects at the cellular level result from changes in a critical or “target” molecule. This target molecule is DNA (deoxyribonucleic acid), which regulates cellular activity and contains genetic information needed for cell replication. The DNA molecule is called a chromosome. Permanent changes in this molecule will alter cell function and may result in cell death.
  • 16. Direct vs. Indirect Effect DNA If an x-ray or some type of particulate radiation interacts with the DNA molecule, this is considered a direct effect. Particulate radiation, because of its mass, is more apt to cause damage to the DNA by this direct effect. Other molecules that contribute to cell function, such as RNA, proteins, and enzymes, may also be affected by the direct effect. x-ray or particulate radiation Direct effect =
  • 17. Direct vs. Indirect Effect H2O ions and free radicals Most of the damage to DNA molecules from x-rays is accomplished through the indirect effect. When x-rays enter a cell, they are much more likely to hit a water molecule because there are a large number of water molecules in each cell. When the x-ray ionizes the water molecule, ions and free radicals are produced which in turn bond with a DNA molecule, changing its structure. Since the x-ray interacted with the water molecule before the DNA was involved, this is considered an indirect effect. x-ray or particulate radiation DNA = Indirect effect
  • 18. A free radical is an atom or molecule that has an unpaired electron in the valence shell, making it highly reactive. These free radicals aggressively join with the DNA molecule to produce damage. In the presence of oxygen, the hydroperoxyl free radical is formed; this is one of the most damaging free radicals that can be produced. Free radicals are the primary mediator of the indirect effects on DNA. Free Radical
  • 19. Cells undamaged: ionization alters the structure of the cells but has no overall negative effect. Sublethal injury: cells are damaged by ionization but the damage is repaired. Mutation: cell injury may be incorrectly repaired, and cell function is altered or the cell may reproduce at an uncontrolled rate (cancer). Cell death: the cell damage is so extensive that the cell is no longer able to reproduce. Cellular Effects
  • 20. Sublethal Injury: Cellular Repair 1. Ionization causes damage to DNA (single-strand break of DNA). 2. Cellular enzymes recognize the damage and coordinate the removal of the damaged section. 3. Additional cell enzymes organize replacement of the damaged section with new material.
  • 21. When the DNA is damaged, cell function may be altered or reproductive capacity may be accelerated. Cancer is the most harmful result of cellular mutation. Mutation Normal Mutation
  • 22. Cell Death If there is extensive damage to the cell following irradiation or if cell division (mitosis) is disrupted, the cell may die. This will depend on how sensitive the cells are to radiation. The loss of a few cells or small group of cells is usually of no consequence, since there are so many cells present in the body. In most cases, the dead cells will soon be replaced through normal reparative processes.
  • 23. Cell Cycle More damage results when the cell is irradiated during the G1/early S portion of the cell cycle (before DNA synthesis); the damaged DNA (chromosome) will be duplicated during DNA synthesis and will result in a break in both arms of the chromosome at the next mitosis. G1 = gap phase 1 in which nuclear components are replicated S = synthesis phase; DNA is synthesized during the last 2/3 of this phase G2 = gap phase 2, a preparatory stage to cell division M = mitosis, during which cells divide Cell most sensitive to radiation
  • 24. 1. High reproductive rate (many mitoses) 2. Undifferentiated (immature) 3. High metabolic rate Radiosensitive Cells Cells that are more easily damaged by radiation are radiosensitive. The characteristics of radiosensitive cells are: Lymphocytes, germ cells, basal cells of skin and mucosa, and erythroblasts are examples of radiosensitive cells.
  • 25. Radioresistant Cells 1. Low reproductive rate (few mitoses) 2. Well differentiated (mature) 3. Low metabolic rate Cells that are not as susceptible to damage from radiation are radioresistant. The characteristics of radioresistant cells are: Nerve and muscle cells are examples of radioresistant cells.
  • 26. Radiation Effect Modifiers The biological response to radiation is dependent on several different factors. These include: • Total Dose: the higher the radiation dose, the greater the potential cellular damage. • Dose Rate: A high dose given over a short period of time (or all at once) will produce more damage than the same dose received over a longer period of time. • Total Area Covered: the more cells that are exposed to radiation, the greater the effects will be.
  • 27. Radiation Effect Modifiers (continued) • Type of tissue: As discussed earlier, radiosensitive cells are more likely to be damaged by radiation than are radioresistant cells. • Age: Because the cells are dividing more frequently in a growing child, young people are affected more by radiation than are older people. • Linear Energy Transfer: This measures the rate of the loss of energy as radiation moves through tissue. Particulate radiation (alpha particles, electrons, etc.) has a higher LET because it has mass and interacts with tissues much more readily than do x-rays.
  • 28. • Oxygen Effect: Radiation effects are more pronounced in the presence of oxygen. Oxygen is required for the formation of the hydroperoxyl free radical, which is the most damaging free radical formed following ionization. Radiation Effect Modifiers (continued)
  • 29. The amount of exposure a patient receives from dental diagnostic radiography (effective dose) is relatively small. Most of the radiation damage will be repaired. The effects of the radiation damage that is not repaired may not show up for many years. The time between the exposure and the appearance of the effects of that exposure is called the latent period. In general, the higher the dose, the shorter the latent period. Latent Period
  • 30. Since repair of radiation injury is not 100%, radiation effects are accumulative. However, these effects will usually not be noticeable, since they are masked by the normal aging processes. The effects from extreme levels of radiation exposure are potentially life threatening. Since these high levels will never be seen with diagnostic radiography, the effects will not be discussed. Check radiology texts or online sources for more information.
  • 31. Somatic Cells vs. Germ Cells There are two general types of cells in the body; these are somatic and genetic. Somatic cells are all the cells except for the germ (reproductive) cells. If somatic cells are irradiated, only the person exposed will be affected. Germ cells are the sperm and ova. If the germ cells are irradiated, the offspring of the individual may be affected.
  • 32. Hormesis Hormesis is a dose response phenomenon in which small doses of a toxin have the opposite effect of large doses. For example, exposing mice to small doses of radiation shortly before exposing them to very high levels of radiation actually decreases the likelihood of cancer. The initial low dose of radiation may activate certain repair mechanisms in the body and these mechanisms are efficient enough to not only neutralize the radiation effects but may even repair other defects not caused by the radiation. There is a lot of debate about hormesis, but the general opinion is that this is not something that can be relied on when discussing the effects of radiation exposure.
  • 33. Dosimetry Measuring the dose of radiation emitted by a radioactive source. As mentioned previously, radiation effects are dependent on the total area covered. If the entire body is exposed, it would be considered whole-body radiation. If only a localized area is exposed, as in dental radiography, it would be called specific-area radiation. The effects from a given dose of radiation would be expected to be more severe if the whole body is exposed to that dose rather than a specific area.
  • 34. Traditional Units SI* Units Roentgen (R) Coulombs per kilogram rad Gray rem Sievert Units of Radiation Measurement * SI = International System of Units; used worldwide
  • 35. Roentgen The Roentgen (R) is the traditional unit of measuring radiation exposure. This measures the ionization of air. (The exact definition of Roentgen is complicated and not worth remembering). The Roentgen measures radiation quantity before the radiation enters the body. There is no exact SI unit comparable to the Roentgen, but in keeping with the metric system it is measured in coulombs per kilogram.
  • 36. The rad (radiation absorbed dose) is the traditional unit used to measure the energy absorbed by the body. The SI unit is the Gray (Gy). 1 Gray = 100 rads; 1 cGy (centiGray) = .01 Gray = 1 rad. rad/Gray
  • 37. The rem (roentgen equivalent man) is the traditional unit used for comparing the effects of different types of ionizing radiation (electromagnetic and particulate). The dose (in rads) is multiplied by a quality (weighting) factor. The quality factor for x-rays is 1. Therefore the dose in rems (dose equivalent) is the same as the dose in rads. For alpha particles the quality factor is 20. Therefore the dose in rems (dose equivalent) would be 20 times the dose in rads for alpha particles. The higher the LET, the higher the qualifying factor. The SI unit is the Sievert (Sv). 1 Sievert = 100 rems; 1cSv (.01 Sievert) = 1 rem. rem/Sievert
  • 38. 1 R = 1 rad = 1 rem 1 Gray = 1 Sievert = 100 rads = 100 rems c (centi) = .01 m (milli) = .001 µ (micro) = .000001 1000 mrem = 1 rem = 1 cSv 100 mrem = 1 mSv = 1000 µSv 1 Sv = 100 cSv = 1,000 mSv = 1,000,000 µSv * For x-rays, not particulate radiation Conversions*
  • 39. Each year, people are exposed to various types of ionizing radiation (listed below) and receive an average dose of 3.6 mSv (360 mrem ) per year. The actual dose depends on the degree of exposure to the ionizing radiation sources. Radon 2 mSv(55%) Cosmic 0.27 mSv (8%) Rocks/soil 0.28 mSv (8%) Food/water 0.4 mSv (11%) Medical x-rays 0.39 mSv (11%) Nuclear medicine 0.14 mSv (4%) Consumer products 0.1 mSv (3%) Other sources <0.01 mSv (<1%) Annual Radiation Exposure
  • 40. Natural (Background) Radiation Environmental radiation that we are exposed to daily is called natural or background radiation. It is composed of both external and internal sources. Background radiation averages 3.0 mSv (300 mrem) per year. External Sources: Cosmic (8%*): Ionizing radiation from space. Increased exposure at higher altitudes and during airline travel. Terrestrial (8%*): Results from radioactive materials in soil and rocks. May be incorporated into some building materials. (See next slide). * Percent of average annual radiation exposure
  • 41. Certain black sand beaches in Brazil produce radiation levels as high as 5 mrem/hour. This would be equivalent to getting a full series of x-ray films every hour (photo left). Some plants in another area of Brazil have absorbed so much radium that they will produce an autoradiograph when placed on photographic paper (photo right).
  • 42. Natural (Background) Radiation (continued) Internal Sources: Radon (55%*): Radon and its decay products enter our homes via the atmosphere and water. Inhalation of these products contributes more than half of our average annual radiation exposure. Food/Water (11%*): Some of the food and water we ingest contains radioactive materials. * Percent of average annual radiation exposure, both natural and artificial
  • 43. Artificial (Man-made) Radiation Artificial radiation results in an annual exposure of about 0.6 mSv (60 mrem). Included are: Medical X-rays (11%*): Diagnostic medical x-rays are the major component of artificial radiation. Therapeutic x-rays contribute a small portion. Dental x-rays account for only 0.1% of the total annual exposure. Nuclear medicine (4%*): Diagnostic and therapeutic Consumer Products (3%*): Dental porcelain, smoke alarms, televisions, airport inspections, etc.. Other Sources (<1%*): Primarily nuclear fallout * Percent of average annual radiation exposure, both natural and artificial
  • 44. Effective Dose Equivalent Exposure and dose are not related to the amount or type of tissue covered by the x-ray beam. A dose (or exposure) of 1 Sv could cover just the teeth or the entire body. Obviously, the overall effects would be different, even though the dose is the same. The effective dose equivalent takes into account the dose, the volume of tissue covered and the radiosensitivity of the cells. Using the effective dose equivalent, different types of x-ray examinations can be more realistically compared regarding the risk factor of each. The following slide lists the effective dose equivalents for some typical radiographic exams.
  • 45. Effective Dose Equivalent AFM* (round, F) 60 µSv AFM* (rect., F) 27 µSv Panoramic 7 µSv Ceph 220 µSv Chest 80 µSv Upper GI 2400 µSv Natural Radiation 3000 µSv Notice that the effective dose equivalent for natural (background) radiation (to which everyone is exposed) is 50 times as much as that for an AFM with round collimation and using F-speed film. *AFM = adult full mouth series of x-ray films
  • 46. Comparable risk from: AFM (cancer) Smoking 1 cigarette (cancer) Drinking 30 cans of diet soda (cancer) Riding a bicycle 10 miles (accident) Driving a car 300 miles (accident) Flying 1000 miles (accident) The preceding slide shows that taking a complete series of radiographs increases the average yearly exposure to the patient by a very small amount. The risk ( of cancer formation) is increased slightly. The following table compares this risk with the risk involved in common activities or habits.
  • 47. The accepted cumulative dose of ionizing radiation during pregnancy is 5 rad (.05 Sv). According to the American Academy of Family Physicians, you would need 50,000 dental x-ray examinations to reach the 5-rad cumulative dose to the fetus. An airline flight of 5 hours results in an exposure of 25 µSv. The exposure to the pelvic region from a full-mouth series of radiographs (done properly) is 1 µSv. (average natural (background) radiation is 8 µSv per day). The decision to order films during pregnancy is a personal one. Because of the relatively low dose, it is not expected that there will be any harm to the fetus. However, my recommendation is to limit the films to those needed to treat the patient during the pregnancy (symptomatic teeth or very active caries). Pregnancy
  • 49. Maximum Permissible Dose (MPD) The maximum permissible dose is the amount of radiation (dose limit) that a person can receive from artificial radiation (effective dose equivalent). These dose limits are recommended by the NCRP* and required by the state in which a dentist practices. The dose limits may vary between the NCRP and the state. There are no dose limits for patients being radiographed. The dentist should only order films that are needed for a diagnosis, and thus keep patient exposure to a minimum (See ALARA). * National Council on Radiation Protection and Measurements
  • 50. Dose limits (MPD’s) are set for occupationally exposed personnel (dentist, dental hygienist, and dental assistant) and for non-occupationally exposed individuals (front-office staff, people in waiting room, etc.). The dose limits are as follows: Maximum Permissible Dose (MPD) Occupationally exposed: Adult 50 mSv (NCRP & Ohio) Minor 5 mSv (Ohio) Pregnant 5 mSv (Ohio) Non-Occupationally exposed: NCRP 5 mSv Ohio 1 mSv
  • 51. Patient Protection It is important to do everything we can to reduce the amount of exposure when a patient has dental radiographs taken. The following slides identify the ways in which we can do this.
  • 52. ALARA ALARA stands for “As Low As Reasonably Achievable”. If we assume that there is no threshold for stochastic effects (mutations and cancer) to occur, then it is important to keep the exposure to the minimum needed to provide an accurate diagnosis. In other words, take only those films needed to properly identify patient problems.
  • 53. Professional Judgment/Selection Criteria Deciding which films are needed for a particular patient is dependent on two things: Professional Judgment and Selection Criteria. Professional Judgment: Through education and experience, each dentist develops an expertise in deciding which films will be needed to obtain an accurate diagnosis. Selection Criteria: In 2005, the ADA, in conjunction with the Food and Drug Administration, released updated guidelines for prescribing dental radiographs. These guidelines identify which films should be taken, based on clinical findings. (For more detailed discussion, see “Self-study: Patient Management/Film Ordering”)
  • 54. Equipment Reliability X-ray equipment must be functioning properly to insure that the patient does not receive unnecessary radiation exposure. The settings for the exposure factors (exposure time, mA, kVp) must accurately reflect the output. Each state has requirements for the inspection of x-ray equipment to make sure that everything is working properly. The Ohio Department of Health requires that equipment be checked every five years (fee charged) and that the operator renew the registration of the equipment every two years (fee charged). If new x-ray equipment is purchased or if an x-ray unit is received from another dentist, the state must be notified. Disposal of old units must also be documented.
  • 55. Direct Current (Constant Potential) 60-cycle Alternating Current Many machines now convert the alternating current into a direct current (constant potential). Instead of cycles going from zero to the maximum, both positive and negative, the voltage stays at the maximum positive value, creating more effective x-ray production. This allows for shorter exposure times and a 20% reduction in patient exposure. Constant Potential X-ray Machine
  • 56. Filtration Low-energy x-rays do not contribute to the formation of an x-ray image; all they do is expose the body to radiation. Therefore, we need to get rid of them. The process of removing these low-energy x-rays from the x-ray beam is known as filtration. Filtration increases the average energy (quality) of the x-ray beam. The x-ray beam becomes more penetrating, providing good image formation on the film with reduced patient exposure. (See “Self-study: X-ray Production” for more information on filtration). Low-energy x-rays high-energy x-ray
  • 57. Collimation Collimation is used to restrict the size of the x-ray beam, covering the entire film with the x-ray beam but not exposing unnecessary tissue. By reducing the amount of tissue exposed, the production of scatter radiation is also reduced. The shape of the opening (round or rectangular) in the collimator determines the shape of the x-ray beam. The size of the opening determines the size of the beam at the end of the PID. If you switch from a 7 cm diameter round PID to a 6 cm diameter round PID, the patient receives 25% less radiation. Rectangular collimation results in the patient receiving 55 % less radiation when compared to what they would receive with a 7 cm round PID. (See “Self-study: X-ray Production” for more on collimation).
  • 58. Focus Film Distance Extending the distance between the target of the x- ray tube (focal spot) and the teeth makes the beam less divergent as it passes through the head, exposing a smaller area of the patient. (The diameter of the beam at the skin surface is the same for both distances. The beam from the 8” target-teeth distance spreads out much more as it passes through the head). 16” 8” Target-teeth 16” Target-teeth 8”
  • 59. Using a faster film requires less radiation. Using F-speed film (Insight) instead of D-speed film reduces patient exposure by 60%. F-speed film has larger silver halide crystals, which more readily intercept the x-rays. (See “Self-study: Film and Screens” for more on films). Intraoral Film Speed
  • 60. Extraoral Screen Speed Extraoral films are exposed by light from intensifying screens; this light is produced when x-rays contact phosphor crystals on the surface of the screens. The light is either blue or green, depending on the type of screen. Intensifying screens have different speeds, depending on the type of phosphor crystal (rare earth recommended) and the thickness of the phosphor layer. The faster the screen is, the less the patient exposure will be. However, image detail decreases as the speed of the screens increases. It is important to make sure that the film is compatible with the color of light coming from the screen. (See “Self-study: Film and Screens” for more on screens).
  • 61. The American Dental Association recommends that a lead apron and thyroid collar be used on all patients. The actual exposure from scatter radiation to other parts of the body is minimal, but considering the ease of placing the lead apron and thyroid collar, there is no reason not to use them. Patients will appreciate your efforts in keeping their exposure to a minimum. (The thyroid collar is not used for panoramic films). Lead Apron/Thyroid Collar
  • 62. Good technique in taking films is essential in producing diagnostic radiographs. Proper film placement and selection of the correct exposure factors will maximize the value of the films and will reduce or eliminate the need for retakes, which would increase the patient’s overall exposure. Technique
  • 63. Processing Processing films for the correct amount of time and at the proper temperature produces films of good diagnostic quality, assuming the films were exposed properly. It is necessary to have appropriate safelighting in a light-tight darkroom. Inadequate processing will result in retaking films which will add to the patient’s overall radiation exposure. (See “Self-study: Processing”).
  • 64. The operator should never hold films in the patient’s mouth during an exposure. Some patient’s, due to physical or mental impairments, may need help in stabilizing the films, but this assistance should be provided by a friend or relative of the patient. This person should wear a lead apron and leaded gloves when holding films in the patient’s mouth. X-ray Protection for the Operator The photo at right shows a squamous cell carcinoma on the finger of a dentist who routinely held films for the patient.
  • 65. The operator should stand behind a protective barrier if available. It has been determined that drywall is adequate protection for this purpose. The operator must be able to observe the patient during the exposure to make sure the patient doesn’t move prior to or during the exposure. If a direct line of sight is not possible, mirrors can be mounted on a wall opposite the doorway to allow visualization of the patient. If barriers are not available, the operator should follow the position and distance rule (next slide). X-ray Protection for the Operator
  • 66. Position and Distance Rule The operator should stand at least six feet away from the patient at an angle between 90 and 135 degrees. As the tubehead is moved, this safe position will change relative to the patient’s head (see below).
  • 67. State Requirements All states have some regulations concerning the operation of x-ray equipment. In Ohio, each dental office must designate a Radiation Safety Officer (any office employee; dentist, dental assistant, hygienist, etc.) who is responsible for maintaining records relating to the x-ray practices. Each office must post a “Notice to Employees”, which briefly lists the responsibilities of the dentist and all employees who take radiographs as detailed in the state’s radiation protection rules. Each office must have a “Safe Operating Procedures” manual and each operator must sign an “Instruction of Individuals” form to indicate that they have read the manual.
  • 68. Personnel-monitoring devices (film badges) can be used to determine the exposure an operator receives during a given period (often quarterly). Film badges are required in some states if you expect to exceed 25% of the MPD during any calendar quarter (12.5 mSv). Although you should not expect to exceed this dose following normal safe operating procedures, it is beneficial to have a dosimetry service. The cost is minimal and the reports, which hopefully identify the lack of exposure to the operators, reduces any apprehension the office staff may have about radiation exposure. Film Badges
  • 69. NCRP Report # 145 The NCRP Report # 145 was released in December, 2003. It listed the following recommendations. The lead apron is not required. The thyroid collar is required for children and should be used for adults. (The ADA, in response to the National Academy of Science report on low-level radiation effects, recommends lead apron/thyroid collar for all patients). Rectangular collimation is required for periapicals and should be used, when feasible, for bitewings.
  • 70. NCRP Report # 145 D-speed film is not to be used. E-speed film or faster is required. (Kodak no longer makes E-speed film; F-speed film, which is faster, is available along with D-speed). Rare earth screens are to be used for pans. Sight development (dip tanks) is not acceptable. Shielding design for new or remodeled dental offices is to be done by a qualified expert. Film badges are required for pregnant personnel.
  • 71. This concludes the section on Radiobiology, Dosimetry, and Radiation Protection. Additional self-study modules are available at: http://dent.osu.edu/radiology/resources.htm If you have any questions, you may e-mail me at: jaynes.1@osu.edu Robert M. Jaynes, DDS, MS Director, Radiology Group College of Dentistry Ohio State University