Medicinal Chemistry, sulpha drugs

1. SULPHA DRUGS
Dept. of Medicinal chemistry
SREE DATTHA INSTITUTE OF PHARMACY
Sheriguda, Ibrahimpatnam
PRESENTED BY
AADI DEVIKA
16U21R0046
Under the guidance of
Asst.Professor Ms.G.Nikitha
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2. CONTENTS
 Introduction
 General mechanism of action
 SAR
 Adverse effects
 Classification
 Uses
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3. INTRODUCTION
 Sulphonamides , a class of bacteriostatic agents are derivatives of p-
aminobenzene sulphonamides which possess antibacterial activity both
gram+ve and gram-ve bacteria.
 Sulphonamides show less resistance when compared to other antibiotics like
pencillins,cephalosporins etc.
 As these drugs are capable of attaining high concentration in plasma for
long duration hence frequent dosing is not required.
 They are inexpensive and offer easy administration.
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4. MECHANISM OF ACTION
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5. SAR OF SULFONAMIDES
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6. CLASSIFICATION
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7. STRUCTURES
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8. Sulphadiazine
It is ashort acting sulphonamide. It is prepared by condensing 2 amino pyrimidine with p
acetamido benzene sulphonyl chloride and hydrolysing obtained product with an alkali.
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9. PROPERTIES
 White/yellow crystalline powder
 Sparingly soluble in water but freely soluble in dilute mineral oils and in
solutions of hyrdoxide &KOH and in ammonia water.
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10. ADVERSE EFFECTS
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11. USES
 Its I.V administration is used against Neisseria causing Meningococcal
Meningitis.
 Sulphadiazine when combined with pyrimethamine is used for treating
malaria.
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