1. RECENT ADVANCES IN
CERAMICS IN ORTHOPAEDICS
DR BIPUL BORTHAKUR
PROFESSOR & HOD
DEPT. OF ORTHOPEDICS
SILCHAR MEDICAL COLLEGE AND HOSPITAL
2. INTRODUCTION
Biomaterial is defined as natural or synthetic substances capable of being
tolerated permanently or temporarily by the human body
Ceramics are one of them
Ceramics are inorganic metallic, semi-metallic or non-metallic solid materials
with varying composition.
3. PROPERTIES OF CERAMIC MATERIALS
Highly inert
Hard but Brittle
High compressive state
Good electric insulator
Good thermal insulator
Good aesthetic appearance
They are lighter than metals
4. BIOCERAMICS ARE CERAMIC MATERIALS DEVELOPED FOR USE IN
MEDICAL IMPLANTS LIKE HARD TISSUE LIKE BONES.
THE BIOACTIVITY OF THE MATERIAL CAN BE DEFINED AS ITS ABILITY
BOND BIOLOGICALLY TO A BONE.
BIOCERAMICS HAVE PLAYED INTEGRAL ROLES IN TREATMENT
MODALITIES FOR DAMAGED AND DISEASES HUMAN JOINTS AND
OSSEOUS DEFECTS.
BIOCERAMICS AND COATINGS ARE EXPECTED TO HAVE INCREASING
USE IN ORTHOPAEDICS BECAUSE OF THEIR UNIQUE COMBINATION
AND RANGE OF PROPERTIES.
5.
6. CERAMICS USED IN ORTHOPAEDIC SURGERY
ARE CLASSIFIED AS:
I. BIOINERT CERAMICS
1ST generation ceramics
Incorporate into bone in accordance with pattern of contact osteogenesis
Maintain Same physical and mechanical properties with living tissue
ALUMINA CERAMIC (AlO3)
ZIRCONIA CERAMIC (ZrO3)
ZIRCONIA TOUGHENED ALUMINA (ZTA) CERAMIC,
OXINIUM MATERIALS (OXIDISED ZIRCONIUM)
7. 2. BIOACTIVE CERAMICS
2ND generation ceramics
Capable of chemical bonding with living tissues (bonding osteogenesis)
Osteoconductive and osteoinductive as it can promote bone formation both along
within bone-implant interface.
HYDROXYAPATITE (which has been sintered at high temperature)
BIOACTIVE BIOGLASS
BIOACTIVE BONE CEMENTS
8. 3. BIORESORBABLE/ BIODEGRADABLE CERAMICS
2nd generation ceramics
Gradually absorbed in vivo and replaced by bone in the bone tissue.
Similar to contact osteogenesis.
Undergo progressive degradation with healing and degeneration of tissues upon
implantation
CALCIUM PHOSPHATES
TRICALCIUM PHOSPHATES
HYDROXYAPATITE (which has been sintered at low temperature)
11. JOINT ARTHROPLASTIES
JOINT REPLACEMENT COMPONENT- FEMORAL HEAD, STEM
THR ACETABULAR INLAYS
THR CONDYLES
KNEE PROSTHESIS
SMALL JOINT PROSTHESIS
BIOCERAMICS APPLIED-
a. ALUMINA CERAMICS
Better wear resistant with stainless steel or Co-Cr alloy
Alumina with metal articulating against polythene shows less wear for the polythene
wear.
Modern alumina has shown to have lower toughness than old alumina even though
with less impurities than old alumina.
12. b. ZIRCONIA CERAMIC (ZrO2)
Has been Introduced because its One of the strongest ceramics to
reduce the risk of fracture
Superior wear resistance with smoother finish
Favoured over UHMWPE due to superior wear resistance
HOWEVER ZARCONIA HEADS SHOULD ARTICULATE ONLY AGAINST
POLYTHENE SOCKETS
c. ZIRCONIA TOUGHENED ALUMINA(ZTA) CERAMIC
Mixed oxide ceramics of 75% alumina, rest zirconium, ytrrium and
chromium oxides
Superior strength AND resistance to wear
Better wear compared to alumina ceramics in vitro
Hip joint stimulator shows promising results
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16. COATING OF IMPLANTS
a. ALUMINA CERAMICS
Coating of IMPLANTS like metallic hip prosthetic stems and small joint prosthesis
b. OXINIUM MATERIALS (OXIDISED ZIRCONIUM)
It is a Thin layer of Zirconium oxide coated on the surface of the solid zirconium metal
Provides Combined effects of METAL AND CERAMIC TO IMPLANTS
Here too,femoral head made of oxinium articulates with a polythene cup
17. c. SYNTHETIC HYDROXYAPATITE-
It is brittle and undergoes slow resorption and give mechanical stress
So it is modified and combined with other materials for improved outcome and
faster resorption
Synthetic HP administered
by means of plasma sprays
18. BONE-GRAFT SUBSTITUTE
1. ALUMINA CERAMIC
2. ZIRCONIA CERAMIC
3. HYDROXYAPATITE
Chosen because it has most similar structure to mineral component of bone
4. BIO-GLASS CERAMICS
5. BIOACTIVE CALCIUM PHOSPHATE BASED BONE CEMENTS
ETEX alpha-BSM
6. TRICALCIUM PHOSPHATE
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21. SPINAL SURGERY
CONDTIONS LIKE REPAIR AND FUSION OF VERTEBRAE
REPAIR OF HERNIATIC DISCS
BIORESORBABLE / BIODEGRADABLE CERAMIC
1. TRICALCIUM PHOSPHATE HAS BEEN SHOWN TO SHOW
COMPARABLE RESULTS TO THOSE WITH AUTOGENOUS BONE.
BETA TRICALCIUM PHOSPHATE IS AVAILABLE IN INJECTABLE
FORM
2. CALCIUM PHOSPHATES
22. BIOACTIVE CERAMICS
As a spacer in –
Iliac crest
Intervertebral spacer
Laminoplasty spacer
23. BIOACTIVE GLASS CERAMICS
Hard , non-porous materials of Calcium, Phosphorus and Silicon dioxide
Osteointegrative and osteoinductive properties
It allows growth of new bone material along and within the bone-implant interface
Bioglass possess and interconnective porous system and bioactivity of its surface
enables the growth of osseous tissues
Incorporation of stainless steel is shown to increase the binding strength
NAMES OF BIOGLASS CERAMICS:
1.BIO GLASS 45S5 / Calcium sodium phosphosilicate
2.BIO GLASS WOLLASTONITE
24. BIO GLASS 45S5 HAS GREATER PRODUCTION OF BONE
COMPARED WITH SYNTHETIC HYDROXYAPATITE.
USES OF BIOGLASS:
1. Bone-graft material
2. Drug delivery system
Drugs which have been used- Teicloplanin
Vancomycin
Condition where used- OSTEOMYELITIS
4. Bone tissue engineering
5. Wollastonite is also used as a spacer at the iliac crest, vertebral prostheses
25. BIOACTIVE BONE CEMENT
Explored in order to avoid complications related to PMMA debris
To enhance fixation of the prosthesis
NAMES OF BIOACTIVE BONE CEMENT INTRODUCED:
1. Calcium-phosphate based bone cement
2. Glass-ceramic bone cement
26. DRUG DELIVERY SYSTEM
CONDITIONS USED-
FILLING OF BONE CYST
BONE LESIONS
CAVITARY OR SEGMENTAL BONE LESIONS
INFECTIONS
27. 1. CALCIUM PHOSPHATE BASED BONE CEMENTS
Bioactive, biocompatible and Bioresorbable bone cement
It is bioresorbable after 12 weeks
Used as BONE VOID FILLER
They are available in INJECTABLE FORM
They are used as DRUG DELIVERY SYSTEM.
NAME OF BONE CEMENTS INTRODUCED:
N-SRS
ETEX alpha- BSM
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30. N- SRS / NORIAN SKELETAL REPAIR SYSTEM
Combination of monocalcium phosphate, tricalcium phosphate, calcium carbonate and
sodium phosphate solution
USES:
Augementation of fracture repair like
Dynamic HIP SCREW FIXATION, Pedical screw fixation.
ETEX ALPHA BSM
It is Calcium orthophosphate cement
USES:
Bone graft substitute
31.
32. OSTEOSET
Composed of Calcium sulphate and Aminoglycosides
Provides structural support to the bone defects
Bio absorbable and biocompatible
IT IS AVAILABLE IN PELLETS.
USES:
Bone-graft substitute
As Drug delivery system, eg. AMINOGLYCOSIDE (tobramycin)
USED IN OSTEOMYELITIS OF TIBIA
33.
34. CONCLUSION
THE EXCELLENT BIOCOMPATIBILTY AND OUTSTANDING PROPERTIES OF
BIOCERAMICS HAVE ENCOURAGED THEIR USE AS BEARINGS IN JOINT
REPLACEMENT.
IMPROVEMENT IN THE MANUFACTURING PROCESS HAS ALLOWED THE
PRODUCTION OF RELAIBALE MATERIALS
CERAMIC COATINGS PROVIDE AN ATTRACTIVE ALTERNATIVE FOR BIOLOGICAL
FIXATION.