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ACTION POTENTIAL- Electro chemical changes in the neuronal cells
is action potential
Action potential is movement of electrical impulses and chemical
signals along the length of neurons.
Electrical impulses help transfer of message along the length of
neuron
Neurotransmitters help in chemical signaling between 2 neurons
Neurons communicate with each other by the help of action
potential
Action potential arises due to difference in extracellular membrane
and intracellular membrane charges
Sodium is main extracellular cation
And potassium is main intracellular cation
The overall internal negative charge of neuronal membranes is due
to the negatively charged proteins
ACTION POTENTIAL STARTS WHEN NEURONAL CHARGE REACHES -
55 mV stimulating Voltage gated Na+ channels to open
Electrical transfer Chemical signaling
NEUROTRANSMITTERS
RESTING MEMBRANE POTENTIAL- internal charge of neuron
membrane at rest which is -70 mV
THRESHHOLD POTENTIAL- minimum amount of charge required to
stimulate action potential which is -55 mV
LOCAL POTENTIAL- it is the influx sodium ions due to stimulation of
mechanoreceptors that opens ligand gated sodium channels
ACTION POTENTIAL STARTS WHEN NEURONAL CHARGE REACHES -
55 mV (threshold potential) stimulating Voltage gated Na+ channels
to open
LOCAL POTENTIAL
Na+
NA+
NA+
Na+
THRESHOLD POTENTIAL
-55 mV
Na+ NA+ NA+
K+
K+
ACTION POTENTIAL
+10 to +40
VOLTAGE GATED
SODIUM CHANNELS
VOLTAGE GATED
POTTASIUM CHANNELS
STAGES IN ACTION POTENTIAL
Resting membrane
potential- internal charge
of neuronal membrane at
rest which is -70 mV. There
is no stimulation at this
stage
Local potential- it arises
when sodium channels are
opened by
mechanoreceptors in
response to stimulus
Depolarization- It occurs when the local membrane potential reaches
threshold potential(-55mV). It leads to opening of voltage gated
sodium channels
When NA+ voltage gated channels are open, there is sodium influx
the internal membrane charge reaches up to +10 to +40 mV
The reversal of charge in neuronal membrane is called as
depolarization
Repolarization- it occurs when voltage gated potassium channels are
opened leading to potassium efflux, the charge again goes back to
-70 to -80 mV
Refractory period- the duration where neurons do not respond to
stimulus. No action potential can be produced in this period
Visual representation of action potential
When sodium enters, the internal negative charge becomes positive
When potassium exits the internal negative charge gets restored
The displacement of internal negative charge due to Na+ influx along
the neuronal membrane leads to depolarization and restoration of
negative charge due to K+ efflux leads to repolarization

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Action potential

  • 1. Do not upload or share without owner permission Pictures and content- osmosis.org ©copyright anurag joseph INSTAGRAM- @medical_lectures_by_anurag
  • 2. ACTION POTENTIAL- Electro chemical changes in the neuronal cells is action potential Action potential is movement of electrical impulses and chemical signals along the length of neurons. Electrical impulses help transfer of message along the length of neuron Neurotransmitters help in chemical signaling between 2 neurons Neurons communicate with each other by the help of action potential Action potential arises due to difference in extracellular membrane and intracellular membrane charges Sodium is main extracellular cation And potassium is main intracellular cation The overall internal negative charge of neuronal membranes is due to the negatively charged proteins ACTION POTENTIAL STARTS WHEN NEURONAL CHARGE REACHES - 55 mV stimulating Voltage gated Na+ channels to open Electrical transfer Chemical signaling NEUROTRANSMITTERS
  • 3. RESTING MEMBRANE POTENTIAL- internal charge of neuron membrane at rest which is -70 mV THRESHHOLD POTENTIAL- minimum amount of charge required to stimulate action potential which is -55 mV LOCAL POTENTIAL- it is the influx sodium ions due to stimulation of mechanoreceptors that opens ligand gated sodium channels ACTION POTENTIAL STARTS WHEN NEURONAL CHARGE REACHES - 55 mV (threshold potential) stimulating Voltage gated Na+ channels to open LOCAL POTENTIAL Na+ NA+ NA+ Na+ THRESHOLD POTENTIAL -55 mV Na+ NA+ NA+ K+ K+ ACTION POTENTIAL +10 to +40 VOLTAGE GATED SODIUM CHANNELS VOLTAGE GATED POTTASIUM CHANNELS
  • 4. STAGES IN ACTION POTENTIAL Resting membrane potential- internal charge of neuronal membrane at rest which is -70 mV. There is no stimulation at this stage Local potential- it arises when sodium channels are opened by mechanoreceptors in response to stimulus Depolarization- It occurs when the local membrane potential reaches threshold potential(-55mV). It leads to opening of voltage gated sodium channels When NA+ voltage gated channels are open, there is sodium influx the internal membrane charge reaches up to +10 to +40 mV The reversal of charge in neuronal membrane is called as depolarization Repolarization- it occurs when voltage gated potassium channels are opened leading to potassium efflux, the charge again goes back to -70 to -80 mV Refractory period- the duration where neurons do not respond to stimulus. No action potential can be produced in this period
  • 5. Visual representation of action potential When sodium enters, the internal negative charge becomes positive When potassium exits the internal negative charge gets restored The displacement of internal negative charge due to Na+ influx along the neuronal membrane leads to depolarization and restoration of negative charge due to K+ efflux leads to repolarization