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Objectives
• Goal /Aim:
• By the end of this session students should be able to understand the mechanism of
production & propagation of electrical changes occurring in excitable tissues.
• Student should be able to:
• To know the types of Disturbances across the Cell Membrane include action
potential & local response
• Define Action Potential
• Describe the Typical Action Potential in Large Myelinated Nerve fiber
• Explain & draw the Stages of Action Potential
• Describe the Types of Channels involved in Various Excitable Tissues
• Tell the difference between Voltage Gated Na+ and K+ Channels
• Describe the Propagation (Transmission) of Action Potential
• Explain Saltatory Conduction
• Differentiate between different Types of Action Potential
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Lesson contents
• Types of Disturbances across the Cell Membrane
• Definition of Action Potential
• Typical Action Potential in Large Myelinated Nerve fiber
• Stages of Action Potential
• Types of Channels involved in Various Excitable Tissues
• Voltage Gated Na+ and K+ Channels
• Na+
and K+
Conductance
• Propagation (Transmission) of Action Potential
• Saltatory Conduction
• Direction of Propagation
• Types of Action Potential
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4. Dr. Rashid Mahmood Dr. Rashid Mahmood
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Types of Disturbances across the Cell
Membrane
• TWO Types:
• Non-Propagated Potentials:
– Synaptic
– Generator
• Propagated
• Action Potential
Action Potential
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Action Potential
• Definition:
– Rapid changes in the membrane potential that spread
rapidly along cell membrane of excitable tissues
– Abrupt / sudden Change (reversal) in resting membrane
potential in response to a threshold stimulus.
– Sequence of events along the membrane of an Excitable
tissue in response to threshold stimuli
• Transmission of signals
• Sudden change, sudden end
• Transmission continues until fiber ends
• Transport of ions
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Activation and Inactivation of Na+
and
K+
Channels
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Summary of mechanism of development of
different stages of Action Potential
1. Resting stage (RMP)
(Polarized state)
-90 mV
1. Depolarization
Stimulus → sudden ↑in
Na+ Permeability
Na+ Leak Channels
From -90 (or-70) mv to
-50 mv
Voltage gated channels
(fast)
from -70 mv onwards
3. Overshoot Potential
4. Repolarization
Closure of Na+ Channels
Inactivation of Na+
Channels (Same
stimulus but Delayed)
Opening of K+ Channels
(Activation by same
stimulus but Delayed)
4. Hyperpolarization:
K+ Channels remain open
Na+ Out
4. Recovery Stage
Na+ K+ ATPase Pump
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Propagation
(Transmission)
of Action
Potential
• Electrotonic
Conduction.
• Local circuit of
Current along both
sides of membrane
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Propagation of Action Potential-II
(Saltatory Conduction)
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Self-Study Topics
• All-or-nothing Principle
– “Safety factor” for propagation
• Rhythmicity
I don’t t each my st udent s, I j ust
provide guidance and environment
conduct ive t o learning.
Albert Einstein (1877-1955)
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Summary
• Types of Disturbances across the Cell Membrane include action potential &
local response
• Action Potential is defined as Rapid changes in the membrane potential that
spread rapidly along cell membrane of excitable tissues
• Main stages of Action Potential include Resting stage (Polarized state),
Depolarization, Overshoot, Repolarization & Recovery Stage
• Types of Channels involved in Various Excitable Tissues include Voltage Gated
Na+ and K+ Channels, Na+
-K+
leak channels, & in some cases Ca++
channels
• Propagation (Transmission) of Action Potential occurs in All directions till the
end of the fiber
• Saltatory Conduction is the Jumping of Action Potential from one Node of
Ranvier to next in Myelinated fibers
• The advantages of Saltatory Conduction include increase velocity of conduction
& Energy Conservation
• Main Types of Action Potential include Spike Potential, Action Potential with
Plateau, Compound Action Potential & Biphasic Action Potential
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Rapid changes in the membrane potential that spread rapidly along cell membrane of excitable tissues.
Abrupt / sudden Change (reversal) in resting membrane potential in response to a threshold stimulus.
Sequence of events along the membrane of an Excitable tissue in response to threshold stimuli
See next slide Resting stage (RMP) (Polarized state)
Latent Period
Threshold (Firing Level)
Depolarization
Overshoot
Repolarization
After-Depolarization
After-Hyperpolarization (Positive After-Potential) (Recovery Stage)
Saltatory Conduction is the Jumping of Action Potential from one Node of Ranvier to next in Myelinated fibers