What is nutrigenomics ,introduction to genomic,introduction to nutrigenomics, examples ,1)folate2) pku 3)lactose intolersnce 2)antiaging Diet disease interaction ,advantages of nutrigenomics ,disadvantages of nutrigenomics why need of nutrigenomic,what are the uses of nutrigenomics,

1. Nutrigenomics

2. Nutrigenomics
• Nutrigenomics is a branch of nutritional Genomics and it
is the study of the effect of food and food constitutes on
gene expression.
• Nutritional Genomics:-
• Nutritional genomic is a science which studies the
relationship between Human Genome, nutrition and
health.
• There are two aspects, viz, Nutrigenomics and
Nutrigenetics.

3. Introduction:-
Genomics:-
• Genomics is an interdisciplinary field of science focusing
on the,
• Structure
• Function
• Evaluation
• Mapping and
• Editing of Genome.

4. Nutrigenomics:-
• Nutrigenomics establishes the effect of ingested nutrients
and other food components on gene expression and gene
regulation.
• It also determines the individual nutritional requirements
based on genetic makeup of the person as well as the
association between diet and chronic diseases.
• It identifies the genesinvolved in physiological response to
diet and the influences of environmental factor on gene
expression.

5. Examples:-
1)Folate:
• Folate is produce Frome folic acid – an essential form of
vitamin B9 found in green vegetables such as broccoli.
• It is needed by the body to make DNA and deficiency in
this nutrient has been connected to a higher risk of
developing cancer
• As Folate is vital for DNA synthesis it also plays an
important role during fatal development.

6. 2) lactose Intolerance:-
• People who are lactose intolerant unable to digest natural
sugar present in milk and other fresh dairy product.
• The genes responsible for making the necessary enzymes(
lactose) is “switch off ” leaving their bodies unable to
produce it
• These people react badly to consuming dairy products.
suffering from Side Effects such as abdominal pain,
bloating, diarrhoea and nausea.

7. 3)Phenylketonuria (PKU):-
• People with this genetic disorder do not produce the
necessary enzyme for breaking down phenylalanine –
an essential amino acid present in dairy products,
meat, fish, nuts and pulses.
• Phenylalanine is usually converted into another amino
acid called tyrosine. However in individuals who lack
the enzyme, it is instead metabolised into
phenylpyruvic acid.
• phenylpyruvic acid build-up in the body leads to
disordered brain development, mental retardation and
seizures.
• Thins means that people with PKU need to stick to a
diet which avoid phenylalanine rich foods.

8. ◆What Does Nutrigenomics Tell ?
• The overall goal of Nutrigenomics is be to develop an
individual nutrition plan to help achieve and maintain the
best health possible.
• When applied correctly information related to
Nutrigenomics and Nutrigenetics can even help to prevent,
treat or even cure certain diseases.

9. How nutrients regulate genes:-
nutrient Gene impact Related disease
Folic acid DNA
methylation
Cancer
Fatty acid Bind to
transcription factor
Obesity
Vitamin D mRNA Kidney diseases
Flavones Increase mRNA
Synthesis
Cancer

10. Applications:-
• Food industry – gluten free diets for celiac diseases,
Probiotics.
• For lactose intolerance.
• Chronic diseases and some type of cancer may be
preventable at least delayed, by sensible diets.
• Providing personalised nutrition advice that will
optimise heath according to the individual needs.

11. Nutrigenomics and Diseases:-
1)Obesity:-
• Due to genetic variation among individual each person
respond to diet differently.
• By exploring the interaction between dietary pattern and
genetic factors, Nutrigenomics aim to suggest prevention
measures and/or treatment to obesity via personal
nutrition.

12. 2)Anti-aging :-
• Ageing of cells occurs because of the accumulation of
excess free radicals formed due to the lack of proper
nutrition to the cells.
• DNA analysis is instrumental in identifying the right
concoction of nutrients need to eliminate the excess free
radicals present in the cells.

13. Diet:- Disease Interaction:-
• About 97% of genes have known to be associated with
human diseases result in monogenic diseases.
• Modifying the dietary intake can prevent some
monogenetic diseases.

14. Advantages:-
• Improving health and preventing diseases through tailored
diet and life style prescription.
• Effectively prevent and manage chronic diseases.
• Improved health quality of life.
• Reduce Health care cost.
• Better understanding of the mechanisms in disease
susceptibility.

15. Disadvantages:-
• Focus on specific nutrient/foods.
• Increased cost associated with personalized diet and
designer foods.

16. Conclusion:-
• Nutrigenomics application to every life would be the
future of the nutrition science and great series of tools
for nutritionists, dieticians, doctor as well as any health
professional that implicates nutrition therapy for the
treatment of diseases.
• It could possibly help into the prevention of diet
related diseases as well as the designing of the
nutritional Strategies and the adverse or beneficial
effect of some food or nutrient.
• Genetic research provides opportunities to prevent
diseases and improve quality of life through functional
food and tailored diets.

17. References:-
• Dr. M. Swaminathan (Ed:2007) Food and Nutrition
(volume 1)
• P. K. Gupta (Ed:2008-2009) Genetics : expression of
gene (chap-5)
• U. Satyanarayana (first published: 2005) Biotechnology :
Regulation of gene expression.
• Nutrigenomics – Journal of Nutrition & food science.

18. •THANK YOU